{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:30:48Z","timestamp":1793406648237,"version":"4.5.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1038\/hr.2011.203","type":"journal-article","created":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T02:42:49Z","timestamp":1322707369000},"page":"399-403","source":"Crossref","is-referenced-by-count":54,"title":["Blood pressure variability in relation to autonomic nervous system dysregulation: the X-CELLENT study"],"prefix":"10.1038","volume":"35","author":[{"given":"Yi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Agnoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Blacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel E","family":"Safar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,12,1]]},"reference":[{"key":"BFhr2011203_CR1","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1161\/01.HYP.36.5.901","volume":"36","author":"M Kikuya","year":"2000","unstructured":"Kikuya M, Hozawa A, Ohokubo T, Tsuji I, Michimata M, Matsubara M, Ota M, Nagai K, Araki T, Satoh H, Ito S, Hisamichi S, Imai Y . Prognostic significance of blood pressure and heart rate variabilities: the Ohasama study. Hypertension 2000; 36: 901\u2013906.","journal-title":"Hypertension"},{"key":"BFhr2011203_CR2","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1097\/00004872-200409000-00012","volume":"22","author":"K Bjorklund","year":"2004","unstructured":"Bjorklund K, Lind L, Zethelius B, Berglund L, Lithell H . Prognostic significance of 24-h ambulatory blood pressure characteristics for cardiovascular morbidity in a population of elderly men. J Hypertens 2004; 22: 1691\u20131697.","journal-title":"J Hypertens"},{"key":"BFhr2011203_CR3","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/S0140-6736(10)60309-1","volume":"375","author":"PM Rothwell","year":"2010","unstructured":"Rothwell PM . Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension. Lancet 2010; 375: 938\u2013948.","journal-title":"Lancet"},{"key":"BFhr2011203_CR4","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/S0140-6736(10)60308-X","volume":"375","author":"PM Rothwell","year":"2010","unstructured":"Rothwell PM, Howard SC, Dolan E, O\u2019Brien E, Dobson JE, Dahl\u00f6f B, Sever PS, Poulter NR . Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet 2010; 375: 895\u2013905.","journal-title":"Lancet"},{"issue":"S8","key":"BFhr2011203_CR5","first-page":"S29","volume":"12","author":"TG Pickering","year":"1994","unstructured":"Pickering TG, James GD . Ambulatory blood pressure and prognosis. J Hypertens 1994; 12 (S8): S29\u2013S33.","journal-title":"J Hypertens"},{"key":"BFhr2011203_CR6","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/ajh.2008.294","volume":"22","author":"K Eguchi","year":"2009","unstructured":"Eguchi K, Ishikawa J, Hoshide S, Pickering TG, Schwartz JE, Shimada K, Kario K . Night time blood pressure variability is a strong predictor for cardiovascular events in patients with type 2 diabetes. Am J Hypertens 2009; 22: 46\u201351.","journal-title":"Am J Hypertens"},{"key":"BFhr2011203_CR7","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1080\/10641960902822518","volume":"31","author":"M Ozawa","year":"2009","unstructured":"Ozawa M, Tamura K, Okano Y, Matsushita Y, Yanagi M, Tsurumi-Ikeya Y, Oshikawa J, Hashimoto T, Masuda S, Wakui H, Shigenaga AI, Azuma K, Ishigami T, Toya Y, Ishikawa T, Umenura S . Identification of an increased short-term blood pressure variability on ambulatory blood pressure monitoring as a coronary risk factor in diabetic hypertensives. Clin Exp Hypertens 2009; 31: 259\u2013270.","journal-title":"Clin Exp Hypertens"},{"key":"BFhr2011203_CR8","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1097\/01.hjh.0000202817.02836.9c","volume":"24","author":"D Lucini","year":"2006","unstructured":"Lucini D, Cusumano G, Bellia A, Kozakova M, Difede G, Lauro R, Pagani M . Is reduced baroreflex gain a component of the metabolic syndrome? Insights from the LINOSA study. J Hypertens 2006; 24: 361\u2013370.","journal-title":"J Hypertens"},{"key":"BFhr2011203_CR9","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.amjhyper.2005.06.027","volume":"19","author":"GM London","year":"2006","unstructured":"London GM, Schmieder R, Calvo C, Asmar R . Indapamide SR versus candesartan and amlodipine in hypertension: the X-CELLENT Study. Am J Hypertens 2006; 19: 113\u2013119.","journal-title":"Am J Hypertens"},{"key":"BFhr2011203_CR10","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1097\/00004872-200305000-00001","volume":"21","author":"E O\u2019Brien","year":"2003","unstructured":"O\u2019Brien E, Asmar R, Beilin L, Imai Y, Mallion JM, Mancia G, Mengden T, Myers M, Padfield P, Palatini P, Parati G, Pickering T, Redon J, Staessen J, Stergiou G, Verdecchia P . European Society of Hypertension recommendations for conventional, ambulatory and home blood pressure measurement. J Hypertens 2003; 21: 821\u2013848.","journal-title":"J Hypertens"},{"key":"BFhr2011203_CR11","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1093\/ajh\/4.3.234","volume":"4","author":"AJ Coats","year":"1991","unstructured":"Coats AJ, Conway J, Sleight P, Meyer TE, Somers VK, Floras JS, Vann Jones J . Interdependence of blood pressure and heart period regulation in mild hypertension. Am J Hypertens 1991; 4: 234\u2013238.","journal-title":"Am J Hypertens"},{"key":"BFhr2011203_CR12","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1161\/01.CIR.0000039106.89299.AB","volume":"106","author":"D Lucini","year":"2002","unstructured":"Lucini D, Mela GS, Malliani A, Pagani M . Impairment in cardiac autonomic regulation preceding arterial hypertension in humans: insights from spectral analysis of beat-by-beat cardiovascular variability. Circulation 2002; 106: 2673\u20132679.","journal-title":"Circulation"},{"key":"BFhr2011203_CR13","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1161\/HYPERTENSIONAHA.109.140103","volume":"54","author":"D Lucini","year":"2009","unstructured":"Lucini D, Zuccotti G, Malacarne M, Scaramuzza A, Riboni S, Palombo C, Pagani M . Early progression of the autonomic dysfunction observed in pediatric type 1 diabetes mellitus. Hypertension 2009; 54: 987\u2013994.","journal-title":"Hypertension"},{"key":"BFhr2011203_CR14","doi-asserted-by":"publisher","first-page":"R748","DOI":"10.1152\/ajpregu.00003.2002","volume":"283","author":"BR Baldridge","year":"2002","unstructured":"Baldridge BR, Burgess DE, Zimmerman EE, Carroll JJ, Sprinkle AG, Speakman RO, Li SG, Brown DR, Taylor RF, Dworkin S, Randall DC . Heart rate-arterial blood pressure relationship in conscious rat before vs. after spinal cord transaction. Am J Physiol Regul Integr Comp Physiol 2002; 283: R748\u2013R756.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFhr2011203_CR15","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/hr.2010.61","volume":"33","author":"K Eguchi","year":"2010","unstructured":"Eguchi K, Schwartz JE, Pickering TG, Hoshide S, Ishikawa J, Shimada K, Kario K . Increased heart rate variability during sleep is a predictor for future cardiovascular events in patients with type 2 diabetes. Hypertens Res 2010; 33: 737\u2013742.","journal-title":"Hypertens Res"},{"key":"BFhr2011203_CR16","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/sj.jhh.1002023","volume":"20","author":"A Ichihara","year":"2006","unstructured":"Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Hayashi M . Ambulatory blood pressure variability and brachial\u2013ankle pulse wave velocity in untreated hypertensive patients. J Hum Hypertens 2006; 20: 529\u2013536.","journal-title":"J Hum Hypertens"},{"key":"BFhr2011203_CR17","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/S0140-6736(10)60235-8","volume":"375","author":"AJ Webb","year":"2010","unstructured":"Webb AJ, Fischer U, Mehta Z, Rothwell PM . Effects of antihypertensive-drug class on interindividual variation in blood pressure and risk of stroke: a systematic review and meta-analysis. Lancet 2010; 375: 906\u2013915.","journal-title":"Lancet"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/hr2011203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr2011203","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr2011203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:08:56Z","timestamp":1684415336000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/hr2011203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,1]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["BFhr2011203"],"URL":"https:\/\/doi.org\/10.1038\/hr.2011.203","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,1]]}}}