{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:11:40Z","timestamp":1780467100826,"version":"3.54.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1038\/hr.2011.233","type":"journal-article","created":{"date-parts":[[2012,2,7]],"date-time":"2012-02-07T10:19:10Z","timestamp":1328609950000},"page":"585-591","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Genetic mapping of habitual substance use, obesity-related traits, responses to mental and physical stress, and heart rate and blood pressure measurements reveals shared genes that are overrepresented in the neural synapse"],"prefix":"10.1038","volume":"35","author":[{"given":"Majid","family":"Nikpay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ondrej","family":"\u0160eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanne","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Petrovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gaudet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore A","family":"Kotchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Allen W","family":"Cowley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Hamet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,2,2]]},"reference":[{"key":"BFhr2011233_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0376-8716(99)00053-8","volume":"57","author":"JM Hettema","year":"1999","unstructured":"Hettema JM, Corey LA, Kendler KS . A multivariate genetic analysis of the use of tobacco, alcohol, and caffeine in a population based sample of male and female twins. Drug Alcohol Depend 1999; 57: 69\u201378.","journal-title":"Drug Alcohol Depend"},{"key":"BFhr2011233_CR2","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S0165-6147(97)01115-2","volume":"19","author":"PV Piazza","year":"1998","unstructured":"Piazza PV, Le Moal M . The role of stress in drug self-administration. Trends Pharmacol Sci 1998; 19: 67\u201374.","journal-title":"Trends Pharmacol Sci"},{"key":"BFhr2011233_CR3","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/nn1452","volume":"8","author":"ND Volkow","year":"2005","unstructured":"Volkow ND, Wise RA . How can drug addiction help us understand obesity? Nat Neurosci 2005; 8: 555\u2013560.","journal-title":"Nat Neurosci"},{"key":"BFhr2011233_CR4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1053\/meta.2002.33186","volume":"51","author":"P Hamet","year":"2002","unstructured":"Hamet P, Tremblay J . Genetic determinants of the stress response in cardiovascular disease. Metabolism 2002; 51: 15\u201324.","journal-title":"Metabolism"},{"key":"BFhr2011233_CR5","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.physbeh.2007.04.011","volume":"91","author":"TC Adam","year":"2007","unstructured":"Adam TC, Epel ES . Stress, eating and the reward system. Physiol Behav 2007; 91: 449\u2013458.","journal-title":"Physiol Behav"},{"key":"BFhr2011233_CR6","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195094831.001.0001","volume-title":"Essential hypertension and its causes: neural and non-neural mechanisms","author":"PI Korner","year":"2007","unstructured":"Korner PI . Essential hypertension and its causes: neural and non-neural mechanisms. New York: Oxford University Press, 2007."},{"key":"BFhr2011233_CR7","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s10519-006-9072-9","volume":"36","author":"CA Prescott","year":"2006","unstructured":"Prescott CA, Madden PAF, Stallings MC . Challenges in genetic studies of the etiology of substance use and substance use disorders: Introduction to the special issue. Behav Genet 2006; 36: 473\u2013482.","journal-title":"Behav Genet"},{"key":"BFhr2011233_CR8","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1093\/ajcn\/87.2.275","volume":"87","author":"SK Musani","year":"2008","unstructured":"Musani SK, Erickson S, Allison DB . Obesity-still highly heritable after all these years. Am J Clin Nutr 2008; 87: 275\u2013276.","journal-title":"Am J Clin Nutr"},{"key":"BFhr2011233_CR9","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1086\/430133","volume":"76","author":"P Hamet","year":"2005","unstructured":"Hamet P, Merlo E, Seda O, Broeckel U, Tremblay J, Kaldunski M, Gaudet D, Bouchard G, Deslauriers B, Gagnon F, Antoniol G, Pausov Z, Labuda M, Jomphe M, Gossard F, Tremblay G, Kirova R, Tonellato P, Orlov SN, Pintos J, Platko J, Hudson TJ, Rioux JD, Kotchen TA, Cowley Jr AW . Quantitative founder-effect analysis of french canadian families identifies specific loci contributing to metabolic phenotypes of hypertension. Am J Hum Genet 2005; 76: 815\u2013832.","journal-title":"Am J Hum Genet"},{"key":"BFhr2011233_CR10","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1038\/nn1583","volume":"8","author":"MJ Kreek","year":"2005","unstructured":"Kreek MJ, Nielsen DA, Butelman ER, LaForge KS . Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nat Neurosci 2005; 8: 1450\u20131457.","journal-title":"Nat Neurosci"},{"key":"BFhr2011233_CR11","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.physbeh.2007.12.011","volume":"94","author":"AG Nieuwenhuizen","year":"2008","unstructured":"Nieuwenhuizen AG, Rutters F . The hypothalamic-pituitary-adrenal-axis in the regulation of energy balance. Physiol Behav 2008; 94: 169\u2013177.","journal-title":"Physiol Behav"},{"key":"BFhr2011233_CR12","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1385\/CT:5:2:109","volume":"5","author":"IG Imumorin","year":"2005","unstructured":"Imumorin IG, Dong YB, Zhu HD, Poole JC, Harshfield GA, Treiber FA, Snieder H . A gene-environment interaction model of stress-induced hypertension. Cardiovasc. Toxicol 2005; 5: 109\u2013132.","journal-title":"Cardiovasc. Toxicol"},{"key":"BFhr2011233_CR13","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1038\/nn1578","volume":"8","author":"EJ Nestler","year":"2005","unstructured":"Nestler EJ . Is there a common molecular pathway for addiction? Nat Neurosci 2005; 8: 1445\u20131449.","journal-title":"Nat Neurosci"},{"key":"BFhr2011233_CR14","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1124\/mi.7.2.7","volume":"7","author":"MJ Kreek","year":"2007","unstructured":"Kreek MJ, LaForge KS . Stress responsivity, addiction, and a functional variant of the human mu-opioid receptor gene. Mol Interv 2007; 7: 74\u201378.","journal-title":"Mol Interv"},{"key":"BFhr2011233_CR15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1093\/biomet\/73.1.13","volume":"73","author":"K-Y Liang","year":"1986","unstructured":"Liang K-Y, Zeger SL . Longitudinal data analysis using generalized linear models. Biometrika 1986; 73: 13\u201322.","journal-title":"Biometrika"},{"key":"BFhr2011233_CR16","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1161\/HYPERTENSIONAHA.107.105247","volume":"51","author":"O Seda","year":"2008","unstructured":"Seda O, Tremblay J, Gaudet D, Brunelle P-L, Gurau A, Merlo E, Pilote L, Orlov SN, Boulva F, Petrovich M, Kotchen TA, Cowley Jr AW, Hamet P . Systematic, genome-wide, sex-specific linkage of cardiovascular traits in french canadians. Hypertension 2008; 51: 1156\u20131162.","journal-title":"Hypertension"},{"key":"BFhr2011233_CR17","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1086\/301844","volume":"62","author":"L Almasy","year":"1998","unstructured":"Almasy L, Blangero J . Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998; 62: 1198\u20131211.","journal-title":"Am J Hum Genet"},{"key":"BFhr2011233_CR18","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1161\/01.HYP.0000188049.23233.fb","volume":"46","author":"Z Pausova","year":"2005","unstructured":"Pausova Z, Gaudet D, Gossard F, Bernard M, Kaldunski ML, Jomphe M, Tremblay J, Hudson TJ, Bouchard G, Kotchen TA, Cowley AW, Hamet P . Genome-wide scan for linkage to obesity-associated hypertension in french canadians. Hypertension 2005; 46: 1280\u20131285.","journal-title":"Hypertension"},{"key":"BFhr2011233_CR19","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/ng786","volume":"30","author":"GR Abecasis","year":"2002","unstructured":"Abecasis GR, Cherny SS, Cookson WO, Cardon LR . Merlin\u2014rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002; 30: 97\u2013101.","journal-title":"Nat Genet"},{"key":"BFhr2011233_CR20","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1101\/gr.071571.107","volume":"18","author":"DL Ge","year":"2008","unstructured":"Ge DL, Zhang KL, Need AC, Martin O, Fellay J, Urban TJ, Telenti A, Goldstein DB . Wgaviewer: Software for genomic annotation of whole genome association studies. Genome Res 2008; 18: 640\u2013643.","journal-title":"Genome Res"},{"key":"BFhr2011233_CR21","doi-asserted-by":"publisher","first-page":"D737","DOI":"10.1093\/nar\/gkl876","volume":"35","author":"WX Zhang","year":"2007","unstructured":"Zhang WX, Zhang Y, Zheng H, Zhang C, Xiong W, Olyarchuk JG, Walker M, Xu WF, Zhao M, Zhao SQ, Zhou Z, Wei LP . Syndb: A synapse protein database based on synapse ontology. Nucleic Acids Res 2007; 35: D737\u2013D741.","journal-title":"Nucleic Acids Res"},{"key":"BFhr2011233_CR22","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1086\/497345","volume":"77","author":"GR Abecasis","year":"2005","unstructured":"Abecasis GR, Wigginton JE . Handling marker-marker linkage disequilibrium: Pedigree analysis with clustered markers. Am J Hum Genet 2005; 77: 754\u2013767.","journal-title":"Am J Hum Genet"},{"key":"BFhr2011233_CR23","doi-asserted-by":"publisher","first-page":"S36","DOI":"10.1002\/1098-2272(2000)19:1+<::AID-GEPI6>3.0.CO;2-M","volume":"19","author":"NM Laird","year":"2000","unstructured":"Laird NM, Horvath S, Xu X . Implementing a unified approach to family based tests of association. Genet Epidemiol 2000; 19: S36\u2013S42.","journal-title":"Genet Epidemiol"},{"key":"BFhr2011233_CR24","doi-asserted-by":"publisher","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","volume":"4","author":"G Dennis","year":"2003","unstructured":"Dennis G, Sherman B, Hosack D, Yang J, Gao W, Lane HC, Lempicki R . David: Database for annotation, visualization, and integrated discovery. Genome Biol 2003; 4: P3.","journal-title":"Genome Biol"},{"key":"BFhr2011233_CR25","doi-asserted-by":"publisher","first-page":"8685","DOI":"10.1073\/pnas.0701361104","volume":"104","author":"KI Goh","year":"2007","unstructured":"Goh KI, Cusick ME, Valle D, Childs B, Vidal M, Barabasi AL . The human disease network. Proc Natl Acad Sci USA 2007; 104: 8685\u20138690.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFhr2011233_CR26","doi-asserted-by":"publisher","first-page":"D77","DOI":"10.1093\/nar\/gkm840","volume":"36","author":"T Obayashi","year":"2008","unstructured":"Obayashi T, Hayashi S, Shibaoka M, Saeki M, Ohta H, Kinoshita K . COXPRESdb: A database of coexpressed gene networks in mammals. Nucleic Acids Res 2008; 36: D77\u2013D82.","journal-title":"Nucleic Acids Res"},{"key":"BFhr2011233_CR27","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/ng0506-500","volume":"38","author":"M Reich","year":"2006","unstructured":"Reich M, Liefeld T, Gould J, Lerner J, Tamayo P, Mesirov JP . Genepattern 2.0. Nat Genet 2006; 38: 500\u2013501.","journal-title":"Nat Genet"},{"key":"BFhr2011233_CR28","doi-asserted-by":"publisher","first-page":"D846","DOI":"10.1093\/nar\/gkn700","volume":"37","author":"MDR Croning","year":"2009","unstructured":"Croning MDR, Marshall MC, McLaren P, Armstrong JD, Grant SGN . G2cdb: The genes to cognition database. Nucleic Acids Res 2009; 37: D846\u2013D851.","journal-title":"Nucleic Acids Res"},{"key":"BFhr2011233_CR29","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/gb-2008-9-8-109","volume":"9","author":"K Kristiansson","year":"2008","unstructured":"Kristiansson K, Naukkarinen J, Peltonen L . Isolated populations and complex disease gene identification. Genome Biol 2008; 9: 9.","journal-title":"Genome Biol"},{"key":"BFhr2011233_CR30","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1037\/0033-2909.129.2.270","volume":"129","author":"JD Kassel","year":"2003","unstructured":"Kassel JD, Stroud LR, Paronis CA . Smoking, stress, and negative affect: Correlation, causation, and context across stages of smoking. Psychol Bull 2003; 129: 270\u2013304.","journal-title":"Psychol Bull"},{"key":"BFhr2011233_CR31","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1111\/j.1530-0277.1991.tb00543.x","volume":"15","author":"AP Larissa","year":"1991","unstructured":"Larissa AP . Stress and alcohol interaction: An update of human research. Alcohol Clin Exp Res 1991; 15: 438\u2013459.","journal-title":"Alcohol Clin Exp Res"},{"key":"BFhr2011233_CR32","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/nrn2234","volume":"8","author":"JA Kauer","year":"2007","unstructured":"Kauer JA, Malenka RC . Synaptic plasticity and addiction. Nat Rev Neurosci 2007; 8: 844\u2013858.","journal-title":"Nat Rev Neurosci"},{"key":"BFhr2011233_CR33","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1017\/S1461145705005912","volume":"9","author":"AM Aleisa","year":"2006","unstructured":"Aleisa AM, Alzoubi KH, Gerges NZ, Alkadhi KA . Nicotine blocks stress-induced impairment of spatial memory and long-term potentiation of the hippocampal ca1 region. Int J Neuropsychopharmacol 2006; 9: 417\u2013426.","journal-title":"Int J Neuropsychopharmacol"},{"key":"BFhr2011233_CR34","doi-asserted-by":"publisher","first-page":"228S","DOI":"10.1038\/oby.2006.314","volume":"14","author":"TL Horvath","year":"2006","unstructured":"Horvath TL . Synaptic plasticity in energy balance regulation. Obesity 2006; 14: 228S\u2013233S.","journal-title":"Obesity"},{"key":"BFhr2011233_CR35","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1083\/jcb.113.5.1057","volume":"113","author":"ML Vitale","year":"1991","unstructured":"Vitale ML, Castillo ARD, Tchakarov L, Trifar\u00f3 JM . Cortical filamentous actin disassembly and scinderin redistribution during chromaffin cell stimulation precede exocytosis, a phenomenon not exhibited by gelsolin. J Cell Biol 1991; 113: 1057\u20131067.","journal-title":"J Cell Biol"},{"key":"BFhr2011233_CR36","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nrg2918","volume":"12","author":"A-L Barabasi","year":"2011","unstructured":"Barabasi A-L, Gulbahce N, Loscalzo J . Network medicine: A network-based approach to human disease. Nat Rev Genet 2011; 12: 56\u201368.","journal-title":"Nat Rev Genet"},{"key":"BFhr2011233_CR37","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/msb4100163","volume":"3","author":"J Loscalzo","year":"2007","unstructured":"Loscalzo J, Kohane I, Barabasi AL . Human disease classification in the postgenomic era: a complex systems approach to human pathobiology. Mol Syst Biol 2007; 3: 124.","journal-title":"Mol Syst Biol"},{"key":"BFhr2011233_CR38","doi-asserted-by":"publisher","first-page":"I21","DOI":"10.1093\/bioinformatics\/btp226","volume":"25","author":"MA Schaub","year":"2009","unstructured":"Schaub MA, Kaplow IM, Sirota M, Do CB, Butte AJ, Batzoglou S . A classifier-based approach to identify genetic similarities between diseases. Bioinform 2009; 25: I21\u2013I29.","journal-title":"Bioinform"},{"key":"BFhr2011233_CR39","doi-asserted-by":"publisher","first-page":"11694","DOI":"10.1073\/pnas.0704820104","volume":"104","author":"A Rzhetsky","year":"2007","unstructured":"Rzhetsky A, Wajngurt D, Park N, Zheng T . Probing genetic overlap among complex human phenotypes. Proc Natl Acad Sci USA 2007; 104: 11694\u201311699.","journal-title":"Proc Natl Acad Sci USA"}],"updated-by":[{"DOI":"10.1038\/hr.2012.48","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T00:00:00Z","timestamp":1338854400000}}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/hr2011233.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T03:01:22Z","timestamp":1713495682000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/hr2011233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,2]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["BFhr2011233"],"URL":"https:\/\/doi.org\/10.1038\/hr.2011.233","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,2]]},"assertion":[{"value":"25 September 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2012","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article has been corrected since advance Online Publication, and a corrigendum is also printed in this issue.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}