{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T09:37:55Z","timestamp":1783244275651,"version":"3.54.6"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2011,6,16]],"date-time":"2011-06-16T00:00:00Z","timestamp":1308182400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1038\/hr.2011.79","type":"journal-article","created":{"date-parts":[[2011,6,16]],"date-time":"2011-06-16T13:38:53Z","timestamp":1308231533000},"page":"981-986","source":"Crossref","is-referenced-by-count":19,"title":["Epigenetic regulation of pulmonary arterial hypertension"],"prefix":"10.1038","volume":"34","author":[{"given":"Xue-Feng","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Zhong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,6,16]]},"reference":[{"key":"BFhr201179_CR1","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1056\/NEJMra035488","volume":"351","author":"HW Farber","year":"2004","unstructured":"Farber HW, Loscalzo J . Pulmonary arterial hypertension. N Engl J Med 2004; 351: 1655\u20131665.","journal-title":"N Engl J Med"},{"key":"BFhr201179_CR2","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1172\/JCI33452","volume":"118","author":"M Rabinovitch","year":"2008","unstructured":"Rabinovitch M . Molecular pathogenesis of pulmonary arterial hypertension. J Clin Invest 2008; 118: 2372\u20132379.","journal-title":"J Clin Invest"},{"key":"BFhr201179_CR3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1440-1843.2006.00778.x","volume":"11","author":"KB Martin","year":"2006","unstructured":"Martin KB, Klinger JR, Rounds SI . Pulmonary arterial hypertension: new insights and new hope. Respirology 2006; 11: 6\u201317.","journal-title":"Respirology"},{"key":"BFhr201179_CR4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1053\/pcad.2002.130041","volume":"45","author":"TK Jeffery","year":"2002","unstructured":"Jeffery TK, Morrell NW . Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension. Prog Cardiovasc Dis 2002; 45: 173\u2013202.","journal-title":"Prog Cardiovasc Dis"},{"key":"BFhr201179_CR5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mvr.2004.06.001","volume":"68","author":"M Mandegar","year":"2004","unstructured":"Mandegar M, Fung YC, Huang W, Remillard CV, Rubin LJ, Yuan JX . Cellular and molecular mechanisms of pulmonary vascular remodeling: role in the development of pulmonary hypertension. Microvasc Res 2004; 68: 75\u2013103.","journal-title":"Microvasc Res"},{"key":"BFhr201179_CR6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.vph.2008.06.003","volume":"49","author":"M Humbert","year":"2008","unstructured":"Humbert M, Montani D, Perros F, Dorfmuller P, Adnot S, Eddahibi S . Endothelial cell dysfunction and cross talk between endothelium and smooth muscle cells in pulmonary arterial hypertension. Vascul Pharmacol 2008; 49: 113\u2013118.","journal-title":"Vascul Pharmacol"},{"key":"BFhr201179_CR7","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/S0140-6736(03)13167-4","volume":"361","author":"JR Runo","year":"2003","unstructured":"Runo JR, Loyd JE . Primary pulmonary hypertension. Lancet 2003; 361: 1533\u20131544.","journal-title":"Lancet"},{"issue":"Suppl 1","key":"BFhr201179_CR8","doi-asserted-by":"crossref","first-page":"S175","DOI":"10.1016\/j.prrv.2006.04.211","volume":"7","author":"P Therese","year":"2006","unstructured":"Therese P . Persistent pulmonary hypertension of the newborn. Paediatr Respir Rev 2006; 7 (Suppl 1): S175\u2013S176.","journal-title":"Paediatr Respir Rev"},{"key":"BFhr201179_CR9","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1161\/CIRCULATIONAHA.109.916098","volume":"121","author":"SL Archer","year":"2010","unstructured":"Archer SL, Marsboom G, Kim GH, Zhang HJ, Toth PT, Svensson EC, Dyck JRB, Gomberg-Maitland M, Thebaud B, Husain AN, Cipriani N, Rehman J . Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target. Circulation 2010; 121: 2661\u20132671.","journal-title":"Circulation"},{"key":"BFhr201179_CR10","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1161\/01.RES.0000237021.65103.24","volume":"99","author":"XQ Wu","year":"2006","unstructured":"Wu XQ, Chang MS, Mitsialis SA, Kourembanas S . Hypoxia regulates bone morphogenetic protein signaling through C-terminal-binding protein 1. Circ Res 2006; 99: 240\u2013247.","journal-title":"Circ Res"},{"key":"BFhr201179_CR11","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1097\/HJH.0b013e32833e08f1","volume":"28","author":"XF Xu","year":"2010","unstructured":"Xu XF, Ma XL, Shen Z, Wu XL, Cheng F, Du LZ . Epigenetic regulation of the endothelial nitric oxide synthase gene in persistent pulmonary hypertension of the newborn rat. J Hypertens 2010; 28: 2227\u20132235.","journal-title":"J Hypertens"},{"key":"BFhr201179_CR12","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.coi.2007.07.016","volume":"19","author":"IM Adcock","year":"2007","unstructured":"Adcock IM, Tsaprouni L, Bhavsar P, Ito K . Epigenetic regulation of airway inflammation. Curr Opin Immunol 2007; 19: 694\u2013700.","journal-title":"Curr Opin Immunol"},{"key":"BFhr201179_CR13","first-page":"2948","volume":"123","author":"XF Xu","year":"2010","unstructured":"Xu XF, Du LZ . Epigenetics in neonatal diseases. Chin Med J 2010; 123: 2948\u20132954.","journal-title":"Chin Med J"},{"key":"BFhr201179_CR14","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1046\/j.1398-9995.2003.00359.x","volume":"59","author":"J Bousquet","year":"2004","unstructured":"Bousquet J, Jacot W, Yssel H, Vignola AM, Humbert M . Epigenetic inheritance of fetal genes in allergic asthma. Allergy 2004; 59: 138\u2013147.","journal-title":"Allergy"},{"key":"BFhr201179_CR15","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature05919","volume":"447","author":"AP Feinberg","year":"2007","unstructured":"Feinberg AP . Phenotypic plasticity and the epigenetics of human disease. Nature 2007; 447: 433\u2013440.","journal-title":"Nature"},{"key":"BFhr201179_CR16","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nature05918","volume":"447","author":"W Reik","year":"2007","unstructured":"Reik W . Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 2007; 447: 425\u2013432.","journal-title":"Nature"},{"key":"BFhr201179_CR17","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrg1655","volume":"6","author":"KD Robertson","year":"2005","unstructured":"Robertson KD . DNA methylation and human disease. Nat Rev Genet 2005; 6: 597\u2013610.","journal-title":"Nat Rev Genet"},{"key":"BFhr201179_CR18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1101\/gad.947102","volume":"16","author":"A Bird","year":"2002","unstructured":"Bird A . DNA methylation patterns and epigenetic memory. Genes Devel 2002; 16: 6\u201321.","journal-title":"Genes Devel"},{"key":"BFhr201179_CR19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0378-1119(01)00721-1","volume":"278","author":"M Nakao","year":"2001","unstructured":"Nakao M . Epigenetics: interaction of DNA methylation and chromatin. Gene 2001; 278: 25\u201331.","journal-title":"Gene"},{"key":"BFhr201179_CR20","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.tibs.2005.12.008","volume":"31","author":"RJ Klose","year":"2006","unstructured":"Klose RJ, Bird AP . Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci 2006; 31: 89\u201397.","journal-title":"Trends Biochem Sci"},{"key":"BFhr201179_CR21","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1126\/science.1063852","volume":"293","author":"PA Jones","year":"2001","unstructured":"Jones PA, Takai D . The role of DNA methylation in mammalian epigenetics. Science 2001; 293: 1068\u20131070.","journal-title":"Science"},{"key":"BFhr201179_CR22","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.tig.2003.09.007","volume":"19","author":"RJ Sims III","year":"2003","unstructured":"Sims III RJ, Nishioka K, Reinberg D . Histone lysine methylation: a signature for chromatin function. Trends Genet 2003; 19: 629\u2013639.","journal-title":"Trends Genet"},{"key":"BFhr201179_CR23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/47412","volume":"403","author":"BD Strahl","year":"2000","unstructured":"Strahl BD, Allis CD . The language of covalent histone modifications. Nature 2000; 403: 41\u201345.","journal-title":"Nature"},{"key":"BFhr201179_CR24","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0092-8674(02)01080-2","volume":"111","author":"BM Turner","year":"2002","unstructured":"Turner BM . Cellular memory and the histone code. Cell 2002; 111: 285\u2013291.","journal-title":"Cell"},{"key":"BFhr201179_CR25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(99)00405-9","volume":"240","author":"VA Spencer","year":"1999","unstructured":"Spencer VA, Davie JR . Role of covalent modifications of histones in regulating gene expression. Gene 1999; 240: 1\u201312.","journal-title":"Gene"},{"key":"BFhr201179_CR26","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0959-437X(03)00020-0","volume":"13","author":"M Iizuka","year":"2003","unstructured":"Iizuka M, Smith MM . Functional consequences of histone modifications. Curr Opin in Genet Devel 2003; 13: 154\u2013160.","journal-title":"Curr Opin in Genet Devel"},{"key":"BFhr201179_CR27","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nmeth0607-480","volume":"4","author":"JM Gilmore","year":"2007","unstructured":"Gilmore JM, Washburn MP . Deciphering the combinatorial histone code. Nat Methods 2007; 4: 480\u2013481.","journal-title":"Nat Methods"},{"key":"BFhr201179_CR28","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1042\/bj20021321","volume":"370","author":"AJ de Ruijter","year":"2003","unstructured":"de Ruijter AJ, van Gennip AH, Caron HN, Kemp S, van Kuilenburg AB . Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 2003; 370: 737\u2013749.","journal-title":"Biochem J"},{"key":"BFhr201179_CR29","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0959-437X(03)00020-0","volume":"13","author":"M Iizuka","year":"2003","unstructured":"Iizuka M, Smith MM . Functional consequences of histone modifications. Curr Opin Genet Dev 2003; 13: 154\u2013160.","journal-title":"Curr Opin Genet Dev"},{"key":"BFhr201179_CR30","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/scdb.1999.0298","volume":"10","author":"PA Grant","year":"1999","unstructured":"Grant PA, Berger SL . Histone acetyltransferase complexes. Semin Cell Devel Biol 1999; 10: 169\u2013177.","journal-title":"Semin Cell Devel Biol"},{"key":"BFhr201179_CR31","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/nrm1761","volume":"6","author":"C Martin","year":"2005","unstructured":"Martin C, Zhang Y . The diverse functions of histone lysine methylation. Nat Rev 2005; 6: 838\u2013849.","journal-title":"Nat Rev"},{"key":"BFhr201179_CR32","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/35104508","volume":"414","author":"H Tamaru","year":"2001","unstructured":"Tamaru H, Selker EU . A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature 2001; 414: 277\u2013283.","journal-title":"Nature"},{"key":"BFhr201179_CR33","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1093\/hmg\/ddp277","volume":"18","author":"A Henckel","year":"2009","unstructured":"Henckel A, Nakabayashi K, Sanz LA, Feil R, Hata K, Arnaud P . Histone methylation is mechanistically linked to DNA methylation at imprinting control regions in mammals. Hum Mol Genet 2009; 18: 3375\u20133383.","journal-title":"Hum Mol Genet"},{"key":"BFhr201179_CR34","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00418-004-0696-7","volume":"122","author":"RM Touyz","year":"2004","unstructured":"Touyz RM, Schiffrin EL . Reactive oxygen species in vascular biology: implications in hypertension. Histochem Cell Biol 2004; 122: 339\u2013352.","journal-title":"Histochem Cell Biol"},{"key":"BFhr201179_CR35","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.resp.2010.08.009","volume":"174","author":"F Perez-Vizcaino","year":"2010","unstructured":"Perez-Vizcaino F, Cogolludo A, Moreno L . Reactive oxygen species signaling in pulmonary vascular smooth muscle. Respir Physiol Neurobiol 2010; 174: 212\u2013220.","journal-title":"Respir Physiol Neurobiol"},{"key":"BFhr201179_CR36","doi-asserted-by":"crossref","first-page":"L881","DOI":"10.1152\/ajplung.00047.2008","volume":"295","author":"CD Fike","year":"2008","unstructured":"Fike CD, Slaughter JC, Kaplowitz MR, Zhang Y, Aschner JL . Reactive oxygen species from NADPH oxidase contribute to altered pulmonary vascular responses in piglets with chronic hypoxia-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 2008; 295: L881\u2013L888.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFhr201179_CR37","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cardiores.2006.02.033","volume":"71","author":"RE Clempus","year":"2006","unstructured":"Clempus RE, Griendling KK . Reactive oxygen species signaling in vascular smooth muscle cells. Cardiovasc Res 2006; 71: 216\u2013225.","journal-title":"Cardiovasc Res"},{"key":"BFhr201179_CR38","doi-asserted-by":"crossref","first-page":"L661","DOI":"10.1152\/ajplung.00269.2005","volume":"290","author":"A Sturrock","year":"2006","unstructured":"Sturrock A, Cahill B, Norman K, Huecksteadt TP, Hill K, Sanders K, Karwande SV, Stringham JC, Bull DA, Gleich M, Kennedy TP, Hoidal JR . Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2006; 290: L661\u2013L673.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFhr201179_CR39","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1089\/152308603770380061","volume":"5","author":"S Wedgwood","year":"2003","unstructured":"Wedgwood S, Black SM . Role of reactive oxygen species in vascular remodeling associated with pulmonary hypertension. Antioxid Redox Signal 2003; 5: 759\u2013769.","journal-title":"Antioxid Redox Signal"},{"key":"BFhr201179_CR40","doi-asserted-by":"crossref","first-page":"L1058","DOI":"10.1152\/ajplung.2001.281.5.L1058","volume":"281","author":"S Wedgwood","year":"2001","unstructured":"Wedgwood S, Dettman RW, Black SM . ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species. Am J Physiol Lung Cell Mol Physiol 2001; 281: L1058\u2013L1067.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFhr201179_CR41","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1164\/ajrccm.164.5.2010104","volume":"164","author":"RH Steinhorn","year":"2001","unstructured":"Steinhorn RH, Albert G, Swartz DD, Russell JA, Levine CR, Davis JM . Recombinant human superoxide dismutase enhances the effect of inhaled nitric oxide in persistent pulmonary hypertension. Am J Respir Crit Care Med 2001; 164: 834\u2013839.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFhr201179_CR42","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1164\/rccm.200605-676OC","volume":"174","author":"S Lakshminrusimha","year":"2006","unstructured":"Lakshminrusimha S, Russell JA, Wedgwood S, Gugino SF, Kazzaz JA, Davis JM, Steinhorn RH . Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertension. Am J Respir Crit Care Med 2006; 174: 1370\u20131377.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFhr201179_CR43","doi-asserted-by":"crossref","first-page":"L305","DOI":"10.1152\/ajplung.00382.2002","volume":"285","author":"S Wedgwood","year":"2003","unstructured":"Wedgwood S, Black SM . Induction of apoptosis in fetal pulmonary arterial smooth muscle cells by a combined superoxide dismutase\/catalase mimetic. Am J Physiol Lung Cell Mol Physiol 2003; 285: L305\u2013L312.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFhr201179_CR44","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1164\/rccm.200702-264OC","volume":"177","author":"F Kamezaki","year":"2008","unstructured":"Kamezaki F, Tasaki H, Yamashita K, Tsutsui M, Koide S, Nakata S, Tanimoto A, Okazaki M, Sasaguri Y, Adachi T, Otsuji Y . Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats. Am J Respir Crit Care Med 2008; 177: 219\u2013226.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFhr201179_CR45","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1161\/01.ATV.0000163846.51473.09","volume":"25","author":"JA Leopold","year":"2005","unstructured":"Leopold JA, Loscalzo J . Oxidative enzymopathies and vascular disease. Arterioscler Thromb Vasc Biol 2005; 25: 1332\u20131340.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BFhr201179_CR46","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1023\/A:1026032404105","volume":"253","author":"AK Banerjee","year":"2003","unstructured":"Banerjee AK, Mandal A, Chanda D, Chakraborti S . Oxidant, antioxidant and physical exercise. Mol Cell Biochem 2003; 253: 307\u2013312.","journal-title":"Mol Cell Biochem"},{"key":"BFhr201179_CR47","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.1046\/j.1432-1327.2000.01597.x","volume":"267","author":"R Dringen","year":"2000","unstructured":"Dringen R, Gutterer JM, Hirrlinger J . Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species. Eur J Biochem 2000; 267: 4912\u20134916.","journal-title":"Eur J Biochem"},{"key":"BFhr201179_CR48","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/sj.cdd.4400959","volume":"9","author":"JS Armstrong","year":"2002","unstructured":"Armstrong JS, Steinauer KK, Hornung B, Irish JM, Lecane P, Birrell GW, Peehl DM, Knox SJ . Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line. Cell Death Differ 2002; 9: 252\u2013263.","journal-title":"Cell Death Differ"},{"key":"BFhr201179_CR49","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1161\/01.ATV.0000133604.20182.cf","volume":"24","author":"FM Faraci","year":"2004","unstructured":"Faraci FM, Didion SP . Vascular protection: superoxide dismutase isoforms in the vessel wall. Arterioscler Thromb Vasc Biol 2004; 24: 1367\u20131373.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BFhr201179_CR50","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cytogfr.2005.01.009","volume":"16","author":"K Miyazono","year":"2005","unstructured":"Miyazono K, Maeda S, Imamura T . BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev 2005; 16: 251\u2013263.","journal-title":"Cytokine Growth Factor Rev"},{"key":"BFhr201179_CR51","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/rr57","volume":"2","author":"M De Caestecker","year":"2001","unstructured":"De Caestecker M, Meyrick B . Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension. Respir Res 2001; 2: 193\u2013197.","journal-title":"Respir Res"},{"key":"BFhr201179_CR52","doi-asserted-by":"crossref","first-page":"L740","DOI":"10.1152\/ajplung.00284.2002","volume":"285","author":"S Zhang","year":"2003","unstructured":"Zhang S, Fantozzi I, Tigno DD, Yi ES, Platoshyn O, Thistlethwaite PA, Kriett JM, Yung G, Rubin LJ, Yuan JX . Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2003; 285: L740\u2013L754.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFhr201179_CR53","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/01.RES.0000126047.82846.20","volume":"94","author":"J West","year":"2004","unstructured":"West J, Fagan K, Steudel W, Fouty B, Lane K, Harral J, Hoedt-Miller M, Tada Y, Ozimek J, Tuder R, Rodman DM . Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle. Circ Res 2004; 94: 1109\u20131114.","journal-title":"Circ Res"},{"key":"BFhr201179_CR54","doi-asserted-by":"crossref","first-page":"L450","DOI":"10.1152\/ajplung.00206.2005","volume":"290","author":"H Takahashi","year":"2006","unstructured":"Takahashi H, Goto N, Kojima Y, Tsuda Y, Morio Y, Muramatsu M, Fukuchi Y . Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 2006; 290: L450\u2013L458.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"BFhr201179_CR55","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1161\/01.CIR.0000012754.72951.3D","volume":"105","author":"C Atkinson","year":"2002","unstructured":"Atkinson C, Stewart S, Upton PD, Machado R, Thomson JR, Trembath RC, Morrell NW . Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor. Circulation 2002; 105: 1672\u20131678.","journal-title":"Circulation"},{"key":"BFhr201179_CR56","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1074\/jbc.M706797200","volume":"283","author":"PB Yu","year":"2008","unstructured":"Yu PB, Deng DY, Beppu H, Hong CC, Lai C, Hoyng SA, Kawai N, Bloch KD . Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells. J Biol Chem 2008; 283: 3877\u20133888.","journal-title":"J Biol Chem"},{"key":"BFhr201179_CR57","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1161\/hc3201.094152","volume":"104","author":"NW Morrell","year":"2001","unstructured":"Morrell NW, Yang X, Upton PD, Jourdan KB, Morgan N, Sheares KK, Trembath RC . Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation 2001; 104: 790\u2013795.","journal-title":"Circulation"},{"key":"BFhr201179_CR58","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1074\/jbc.M111023200","volume":"277","author":"O Korchynskyi","year":"2002","unstructured":"Korchynskyi O, ten Dijke P . Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J Biol Chem 2002; 277: 4883\u20134891.","journal-title":"J Biol Chem"},{"key":"BFhr201179_CR59","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/ppul.20201","volume":"39","author":"S Dakshinamurti","year":"2005","unstructured":"Dakshinamurti S . Pathophysiologic mechanisms of persistent pulmonary hypertension of the newborn. Pediatr Pulmonol 2005; 39: 492\u2013503.","journal-title":"Pediatr Pulmonol"},{"key":"BFhr201179_CR60","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1586\/erc.09.186","volume":"8","author":"S Rao","year":"2010","unstructured":"Rao S, Bartle D, Patole S . Current and future therapeutic options for persistent pulmonary hypertension in the newborn. Expert Rev Cardiovasc Ther 2010; 8: 845\u2013862.","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"BFhr201179_CR61","doi-asserted-by":"crossref","first-page":"e272","DOI":"10.1542\/peds.2006-3037","volume":"120","author":"S Hernandez-Diaz","year":"2007","unstructured":"Hernandez-Diaz S, Van Marter LJ, Werler MM, Louik C, Mitchell AA . Risk factors for persistent pulmonary hypertension of the newborn. Pediatrics 2007; 120: e272\u2013e282.","journal-title":"Pediatrics"},{"key":"BFhr201179_CR62","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.pharmthera.2007.03.006","volume":"114","author":"T Hoehn","year":"2007","unstructured":"Hoehn T . Therapy of pulmonary hypertension in neonates and infants. Pharmacol Ther 2007; 114: 318\u2013326.","journal-title":"Pharmacol Ther"},{"key":"BFhr201179_CR63","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/01.CIR.0000102381.57477.50","volume":"109","author":"R Budhiraja","year":"2004","unstructured":"Budhiraja R, Tuder RM, Hassoun PM . Endothelial dysfunction in pulmonary hypertension. Circulation 2004; 109: 159\u2013165.","journal-title":"Circulation"},{"key":"BFhr201179_CR64","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1006\/niox.2001.0400","volume":"6","author":"AP Smith","year":"2002","unstructured":"Smith AP, Demoncheaux EA, Higenbottam TW . Nitric oxide gas decreases endothelin-1 mRNA in cultured pulmonary artery endothelial cells. Nitric Oxide 2002; 6: 153\u2013159.","journal-title":"Nitric Oxide"},{"key":"BFhr201179_CR65","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1542\/peds.101.3.325","volume":"101","author":"D Davidson","year":"1998","unstructured":"Davidson D, Barefield ES, Kattwinkel J, Dudell G, Damask M, Straube R, Rhines J, Chang CT . Inhaled nitric oxide for the early treatment of persistent pulmonary hypertension of the term newborn: a randomized, double-masked, placebo-controlled, dose-response, multicenter study. The I-NO\/PPHN Study Group. Pediatrics 1998; 101: 325\u2013334.","journal-title":"Pediatrics"},{"key":"BFhr201179_CR66","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1056\/NEJM200002173420704","volume":"342","author":"RH Clark","year":"2000","unstructured":"Clark RH, Kueser TJ, Walker MW, Southgate WM, Huckaby JL, Perez JA, Roy BJ, Keszler M, Kinsella JP . Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical Inhaled Nitric Oxide Research Group. N Engl J Med 2000; 342: 469\u2013474.","journal-title":"N Engl J Med"},{"key":"BFhr201179_CR67","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1056\/NEJM199702273360902","volume":"336","author":"JD Roberts Jr","year":"1997","unstructured":"Roberts Jr JD, Fineman JR, Morin III FC, Shaul PW, Rimar S, Schreiber MD, Polin RA, Zwass MS, Zayek MM, Gross I, Heymann MA, Zapol WM . Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group. N Engl J Med 1997; 336: 605\u2013610.","journal-title":"N Engl J Med"},{"key":"BFhr201179_CR68","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s00018-005-5421-8","volume":"63","author":"JE Fish","year":"2006","unstructured":"Fish JE, Marsden PA . Endothelial nitric oxide synthase: insight into cell-specific gene regulation in the vascular endothelium. Cell Mol Life Sci 2006; 63: 144\u2013162.","journal-title":"Cell Mol Life Sci"},{"key":"BFhr201179_CR69","doi-asserted-by":"crossref","first-page":"L1005","DOI":"10.1152\/ajplung.1997.272.5.L1005","volume":"16","author":"PW Shaul","year":"1997","unstructured":"Shaul PW, Yuhanna IS, German Z, Chen Z, Steinhorn RH, Morin FC . Pulmonary endothelial NO synthase gene expression is decreased in fetal lambs with pulmonary hypertension. Am J Physiol-Lung C 1997; 16: L1005\u2013L1012.","journal-title":"Am J Physiol-Lung C"},{"key":"BFhr201179_CR70","doi-asserted-by":"crossref","first-page":"L1013","DOI":"10.1152\/ajplung.1997.272.5.L1013","volume":"16","author":"E Villamor","year":"1997","unstructured":"Villamor E, LeCras TD, Horan MP, Halbower AC, Tuder RM, Abman SH . Chronic intrauterine pulmonary hypertension impairs endothelial nitric oxide synthase in the ovine fetus. Am J Physiol-Lung C 1997; 16: L1013\u2013L1020.","journal-title":"Am J Physiol-Lung C"},{"key":"BFhr201179_CR71","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1172\/JCI786","volume":"101","author":"TD Le Cras","year":"1998","unstructured":"Le Cras TD, Tyler RC, Horan MP, Morris KG, Tuder RM, McMurtry IF, Johns RA, Abman SH . Effects of chronic hypoxia and altered hemodynamics on endothelial nitric oxide synthase expression in the adult rat lung. J Clin Invest 1998; 101: 795\u2013801.","journal-title":"J Clin Invest"},{"key":"BFhr201179_CR72","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1007\/s00134-003-1892-y","volume":"29","author":"T Hoehn","year":"2003","unstructured":"Hoehn T, Preston AA, McPhaden AR, Stiller B, Vogel M, Buhrer C, Wadsworth RM . Endothelial nitric oxide synthase (NOS) is upregulated in rapid progressive pulmonary hypertension of the newborn. Intens Care Med 2003; 29: 1757\u20131762.","journal-title":"Intens Care Med"},{"key":"BFhr201179_CR73","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3109\/14767058.2010.482608","volume":"24","author":"XF Xu","year":"2011","unstructured":"Xu XF, Gu WZ, Wu XL, Li RY, Du LZ . Fetal pulmonary vascular remodeling in a rat model induced by hypoxia and indomethacin. J Matern Fetal Neonatal Med 2011; 24: 172\u2013182.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"BFhr201179_CR74","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1161\/01.ATV.0000109171.50229.33","volume":"24","author":"SC Tai","year":"2004","unstructured":"Tai SC, Robb GB, Marsden PA . Endothelial nitric oxide synthase: a new paradigm for gene regulation in the injured blood vessel. Arterioscl Throm Vas 2004; 24: 405\u2013412.","journal-title":"Arterioscl Throm Vas"},{"key":"BFhr201179_CR75","doi-asserted-by":"crossref","first-page":"C803","DOI":"10.1152\/ajpcell.00457.2005","volume":"291","author":"CD Searles","year":"2006","unstructured":"Searles CD . Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression. Am J Physiol-Cell Ph 2006; 291: C803\u2013C816.","journal-title":"Am J Physiol-Cell Ph"},{"key":"BFhr201179_CR76","doi-asserted-by":"crossref","first-page":"35087","DOI":"10.1074\/jbc.M405063200","volume":"279","author":"Y Chan","year":"2004","unstructured":"Chan Y, Fish JE, D\u2019Abreo C, Lin S, Robb GB, Teichert AM, Karantzoulis-Fegaras F, Keightley A, Steer BM, Marsden PA . The cell-specific expression of endothelial nitric-oxide synthase: a role for DNA methylation. J Biol Chem 2004; 279: 35087\u201335100.","journal-title":"J Biol Chem"},{"key":"BFhr201179_CR77","doi-asserted-by":"crossref","first-page":"24824","DOI":"10.1074\/jbc.M502115200","volume":"280","author":"JE Fish","year":"2005","unstructured":"Fish JE, Matouk CC, Rachlis A, Lin S, Tai SC, D\u2019Abreo C, Marsden PA . The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code. J Biol Chem 2005; 280: 24824\u201324838.","journal-title":"J Biol Chem"},{"key":"BFhr201179_CR78","doi-asserted-by":"crossref","first-page":"16467","DOI":"10.1074\/jbc.M412960200","volume":"280","author":"Y Gan","year":"2005","unstructured":"Gan Y, Shen YH, Wang J, Wang X, Utama B, Wang J, Wang XL . Role of histone deacetylation in cell-specific expression of endothelial nitric-oxide synthase. J Biol Chem 2005; 280: 16467\u201316475.","journal-title":"J Biol Chem"},{"key":"BFhr201179_CR79","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1091\/mbc.e07-11-1186","volume":"19","author":"MX Zhang","year":"2008","unstructured":"Zhang MX, Zhang C, Shen YH, Wang J, Li XN, Chen L, Zhang Y, Coselli JS, Wang XL . Effect of 27nt small RNA on endothelial nitric-oxide synthase expression. Mol Biol Cell 2008; 19: 3997\u20134005.","journal-title":"Mol Biol Cell"},{"key":"BFhr201179_CR80","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molmed.2009.11.003","volume":"16","author":"AE Handel","year":"2010","unstructured":"Handel AE, Ebers GC, Ramagopalan SV . Epigenetics: molecular mechanisms and implications for disease. Trends Mol Med 2010; 16: 7\u201316.","journal-title":"Trends Mol Med"},{"key":"BFhr201179_CR81","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2217\/epi.10.27","volume":"2","author":"A Durham","year":"2010","unstructured":"Durham A, Chou PC, Kirkham P, Adcock IM . Epigenetics in asthma and other inflammatory lung diseases. Epigenomics-UK 2010; 2: 523\u2013537.","journal-title":"Epigenomics-UK"},{"key":"BFhr201179_CR82","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1200\/JCO.2000.18.5.956","volume":"18","author":"P Wijermans","year":"2000","unstructured":"Wijermans P, Lubbert M, Verhoef G, Bosly A, Ravoet C, Andre M, Ferrant A . Low-dose 5-aza-2\u2032-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients. J Clin Oncol 2000; 18: 956\u2013962.","journal-title":"J Clin Oncol"},{"key":"BFhr201179_CR83","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/cncr.21792","volume":"106","author":"H Kantarjian","year":"2006","unstructured":"Kantarjian H, Issa JP, Rosenfeld CS, Bennett JM, Albitar M, DiPersio J, Klimek V, Slack J, de Castro C, Ravandi F, Helmer III R, Shen L, Nimer SD, Leavitt R, Raza A, Saba H . Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 2006; 106: 1794\u20131803.","journal-title":"Cancer"},{"key":"BFhr201179_CR84","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1182\/blood-2004-05-1693","volume":"105","author":"JC Byrd","year":"2005","unstructured":"Byrd JC, Marcucci G, Parthun MR, Xiao JJ, Klisovic RB, Moran M, Lin TS, Liu S, Sklenar AR, Davis ME, Lucas DM, Fischer B, Shank R, Tejaswi SL, Binkley P, Wright J, Chan KK, Grever MR . A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia. Blood 2005; 105: 959\u2013967.","journal-title":"Blood"},{"key":"BFhr201179_CR85","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1182\/blood-2006-06-025999","volume":"109","author":"M Duvic","year":"2007","unstructured":"Duvic M, Talpur R, Ni X, Zhang C, Hazarika P, Kelly C, Chiao JH, Reilly JF, Ricker JL, Richon VM, Frankel SR . Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood 2007; 109: 31\u201339.","journal-title":"Blood"},{"key":"BFhr201179_CR86","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1126\/science.1089523","volume":"302","author":"AS Yang","year":"2003","unstructured":"Yang AS, Estecio MR, Garcia-Manero G, Kantarjian HM, Issa JP . Comment on \u2018chromosomal instability and tumors promoted by DNA hypomethylation\u2019 and \u2018induction of tumors in nice by genomic hypomethylation\u2019. Science 2003; 302: 1153; author reply 1153.","journal-title":"Science"},{"key":"BFhr201179_CR87","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1126\/science.1083557","volume":"300","author":"A Eden","year":"2003","unstructured":"Eden A, Gaudet F, Waghmare A, Jaenisch R . Chromosomal instability and tumors promoted by DNA hypomethylation. Science 2003; 300: 455.","journal-title":"Science"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/hr201179.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr201179","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr201179.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:09:50Z","timestamp":1684429790000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/hr201179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,16]]},"references-count":87,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["BFhr201179"],"URL":"https:\/\/doi.org\/10.1038\/hr.2011.79","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,16]]}}}