{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:08:23Z","timestamp":1770984503646,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T00:00:00Z","timestamp":1349913600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1038\/hr.2012.141","type":"journal-article","created":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T06:06:03Z","timestamp":1349935563000},"page":"196-201","source":"Crossref","is-referenced-by-count":10,"title":["Cilnidipine regulates glucose metabolism and levels of high-molecular adiponectin in diet-induced obese mice"],"prefix":"10.1038","volume":"36","author":[{"given":"Daisuke","family":"Ueno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koto","family":"Gotoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Kakuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Yoshimatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,10,11]]},"reference":[{"key":"BFhr2012141_CR1","doi-asserted-by":"publisher","first-page":"397","DOI":"10.2174\/1573399810602040397","volume":"2","author":"AP Kong","year":"2006","unstructured":"Kong AP, Chan NN, Chan JC . The role of adipocytokines and neurohormonal dysregulation in metabolic syndrome. Curr Diabetes Rev 2006; 2: 397\u2013407.","journal-title":"Curr Diabetes Rev"},{"key":"BFhr2012141_CR2","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.jacc.2010.05.034","volume":"56","author":"S Mottillo","year":"2010","unstructured":"Mottillo S, Filion KB, Genest J, Joseph L, Pilote L, Poirier P, Rinfret S, Schiffrin EL, Eisenberg MJ . The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol 2010; 56: 1113\u20131132.","journal-title":"J Am Coll Cardiol"},{"key":"BFhr2012141_CR3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0014-5793(89)81169-X","volume":"244","author":"HA Pershadsingh","year":"1989","unstructured":"Pershadsingh HA, Lee LY, Snowdowne KW . Evidence for a sodium\/calcium exchanger and voltage-dependent calcium channels in adipocytes. FEBS Lett 1989; 244: 89\u201392.","journal-title":"FEBS Lett"},{"key":"BFhr2012141_CR4","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/0167-4889(85)90231-9","volume":"844","author":"E Nanberg","year":"1985","unstructured":"Nanberg E, Connolly E, Nedergaard J . Presence of a Ca2+-dependent K+ channel in brown adipocytes. Possible role in maintenance of alpha 1-adrenergic stimulation. Biochim Biophys Acta 1985; 844: 42\u201349.","journal-title":"Biochim Biophys Acta"},{"key":"BFhr2012141_CR5","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1161\/01.HYP.0000225402.69580.1d","volume":"48","author":"K Araki","year":"2006","unstructured":"Araki K, Masaki T, Katsuragi I, Tanaka K, Kakuma T, Yoshimatsu H . Telmisartan prevents obesity and increases the expression of uncoupling protein 1 in diet-induced obese mice. Hypertension 2006; 48: 51\u201357.","journal-title":"Hypertension"},{"key":"BFhr2012141_CR6","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1161\/01.HYP.0000215181.60228.f7","volume":"47","author":"K Sugimoto","year":"2006","unstructured":"Sugimoto K, Qi NR, Kazdova L, Pravenec M, Ogihara T, Kurtz TW . Telmisartan but not valsartan increases caloric expenditure and protects against weight gain and hepatic steatosis. Hypertension 2006; 47: 1003\u20131009.","journal-title":"Hypertension"},{"key":"BFhr2012141_CR7","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1291\/hypres.26.383","volume":"26","author":"S Yagi","year":"2003","unstructured":"Yagi S, Goto S, Yamamoto T, Kurihara S, Katayama S . Effect of cilnidipine on insulin sensitivity in patients with essential hypertension. Hypertens Res 2003; 26: 383\u2013387.","journal-title":"Hypertens Res"},{"key":"BFhr2012141_CR8","doi-asserted-by":"publisher","first-page":"2917","DOI":"10.1016\/j.febslet.2006.04.028","volume":"580","author":"Y Matsuzawa","year":"2006","unstructured":"Matsuzawa Y . The metabolic syndrome and adipocytokines. FEBS Lett 2006; 580: 2917\u20132921.","journal-title":"FEBS Lett"},{"key":"BFhr2012141_CR9","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1210\/er.2005-0005","volume":"26","author":"T Kadowaki","year":"2005","unstructured":"Kadowaki T, Yamauchi T . Adiponectin and adiponectin receptors. Endocr Rev 2005; 26: 439\u2013451.","journal-title":"Endocr Rev"},{"key":"BFhr2012141_CR10","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.it.2003.10.013","volume":"25","author":"P Dandona","year":"2004","unstructured":"Dandona P, Aljada A, Bandyopadhyay A . Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 2004; 25: 4\u20137.","journal-title":"Trends Immunol"},{"key":"BFhr2012141_CR11","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1038\/39335","volume":"389","author":"KT Uysal","year":"1997","unstructured":"Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS . Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997; 389: 1997.","journal-title":"Nature"},{"key":"BFhr2012141_CR12","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.mce.2009.08.018","volume":"316","author":"S Galic","year":"2010","unstructured":"Galic S, Oakhill JS, Steinberg GR . Adipose tissue as an endocrine organ. Mol Cell Endocrinol 2010; 316: 129\u2013139.","journal-title":"Mol Cell Endocrinol"},{"key":"BFhr2012141_CR13","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/hep.20282","volume":"40","author":"T Masaki","year":"2004","unstructured":"Masaki T, Chiba S, Tatsukawa H, Yasuda T, Noguchi H, Seike M, Yoshimatsu H . Adiponectin protects LPS-induced liver injury through modulation of TNF-alpha in KK-Ay obese mice. Hepatology 2004; 40: 177\u2013184.","journal-title":"Hepatology"},{"key":"BFhr2012141_CR14","doi-asserted-by":"publisher","first-page":"2266","DOI":"10.2337\/diabetes.52.9.2266","volume":"52","author":"T Masaki","year":"2003","unstructured":"Masaki T, Chiba S, Yasuda T, Tsubone T, Kakuma T, Shimomura I, Funahashi T, Matsuzawa Y, Yoshimatsu H . Peripheral, but not central, administration of adiponectin reduces visceral adiposity and upregulates the expression of uncoupling protein in agouti yellow (Ay\/a) obese mice. Diabetes 2003; 52: 2266\u20132273.","journal-title":"Diabetes"},{"key":"BFhr2012141_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cccn.2004.02.020","volume":"344","author":"K Shimada","year":"2004","unstructured":"Shimada K, Miyazaki T, Daida H . Adiponectin and atherosclerotic disease. Clin Chem Acta 2004; 344: 1\u201312.","journal-title":"Clin Chem Acta"},{"key":"BFhr2012141_CR16","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.2337\/diabetes.50.5.1126","volume":"50","author":"K Hotta","year":"2001","unstructured":"Hotta K, Funahashi T, Bodkin NL, Ortmeyer HK, Arita Y, Hansen BC, Matsuzawa Y . Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 2001; 50: 1126\u20131233.","journal-title":"Diabetes"},{"key":"BFhr2012141_CR17","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1097\/HJH.0b013e328336ade3","volume":"28","author":"YY Fan","year":"2010","unstructured":"Fan YY, Kohno M, Nakano D, Ohsaki H, Kobori H, Suwarni D, Ohashi N, Hitomi H, Asanuma K, Noma T, Tomino Y, Fujita T, Nishiyama A . Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats: possible involvement of N-type calcium channel in podocyte. J Hypertens 2010; 28: 1034\u20131043.","journal-title":"J Hypertens"},{"key":"BFhr2012141_CR18","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.lfs.2007.05.004","volume":"8","author":"M Yono","year":"2007","unstructured":"Yono M, Yamamoto Y, Yoshida M, Ueda S, Latifpour J . Effects of doxazosin on blood flow and mRNA expression of nitric oxide synthase in the spontaneously hypertensive rat genitourinary tract. Life Sci 2007; 8: 218\u2013222.","journal-title":"Life Sci"},{"key":"BFhr2012141_CR19","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.2337\/diabetes.48.5.1113","volume":"48","author":"S Jacob","year":"1999","unstructured":"Jacob S, Machann J, Rett K, Brechtel K, Volk A, Renn W, Maerker E, Matthaei S, Schick F, Claussen CD, Haring HU . Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 1999; 48: 1113\u20131119.","journal-title":"Diabetes"},{"key":"BFhr2012141_CR20","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/j.1755-5922.2009.00126.x","volume":"29","author":"T Masuda","year":"2011","unstructured":"Masuda T, Ogura MN, Moriya T, Takahira N, Matsumoto T, Kutsuna T, Hara M, Aiba N, Noda C, Izumi T . Beneficial effects of L- and N-type calcium channel blocker on glucose and lipid metabolism and renal function in patients with hypertension and type ii diabetes mellitus. Cardiovasc Ther 2011; 29: 46\u201353.","journal-title":"Cardiovasc Ther"},{"key":"BFhr2012141_CR21","doi-asserted-by":"publisher","first-page":"S62","DOI":"10.1038\/ijo.2008.208","volume":"32","author":"B Thorens","year":"2008","unstructured":"Thorens B . Glucose sensing and the pathogenesis of obesity and type 2 diabetes. Int J Obes (Lond) 2008; 32: S62\u2013S71.","journal-title":"Int J Obes (Lond)"},{"key":"BFhr2012141_CR22","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.mehy.2003.11.007","volume":"62","author":"MF McCarty","year":"2004","unstructured":"McCarty MF . Elevated sympathetic activity may promote insulin resistance syndrome by activating alpha-1 adrenergic receptors on adipocytes. Med Hypotheses 2004; 62: 830\u2013838.","journal-title":"Med Hypotheses"},{"key":"BFhr2012141_CR23","doi-asserted-by":"publisher","first-page":"E627","DOI":"10.1152\/ajpendo.00079.2004","volume":"289","author":"AH Mulder","year":"2005","unstructured":"Mulder AH, Tack CJ, Olthaar AJ, Smits P, Sweep FC, Bosch RR . A drenergic receptor stimulation attenuates insulin-stimulated glucose uptake in 3T3-L1 adipocytes by inhibiting GLUT4 translocation. Am J Physiol Endocrinol Metab 2005; 289: E627\u2013E633.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFhr2012141_CR24","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.2337\/diabetes.51.6.1884","volume":"50","author":"N Stefan","year":"2002","unstructured":"Stefan N, Vozarova B, Funahashi T, Matsuzawa Y, Weyer C, Lindsay RS, Youngren JF, Havel PJ, Pratley RE, Bogardus C, Tataranni PA . Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans. Diabetes 2002; 50: 1884\u20131888.","journal-title":"Diabetes"},{"key":"BFhr2012141_CR25","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1038\/nm788","volume":"8","author":"T Yamauchi","year":"2002","unstructured":"Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T . Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002; 8: 1288\u20131295.","journal-title":"Nat Med"},{"key":"BFhr2012141_CR26","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.tips.2009.02.004","volume":"30","author":"S Shetty","year":"2009","unstructured":"Shetty S, Kusminski CM, Scherer PE . Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies. Trends Pharmacol Sci 2009; 30: 234\u2013239.","journal-title":"Trends Pharmacol Sci"},{"key":"BFhr2012141_CR27","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.5551\/jat.6106","volume":"17","author":"H Hirose","year":"2010","unstructured":"Hirose H, Yamamoto Y, Seino-Yoshihara Y, Kawabe H, Saito I . Serum high-molecular-weight adiponectin as a marker for the evaluation and care of subjects with metabolic syndrome and related disorders. J Atheroscler Thromb 2010; 17: 1201\u20131211.","journal-title":"J Atheroscler Thromb"},{"key":"BFhr2012141_CR28","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.1161\/01.RES.0000119921.86460.37","volume":"94","author":"H Kobayashi","year":"2004","unstructured":"Kobayashi H, Ouchi N, Kihara S, Walsh K, Kumada M, Abe Y, Funahashi T, Matsuzawa Y . Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ Res 2004; 94: e27\u2013e31.","journal-title":"Circ Res"},{"key":"BFhr2012141_CR29","doi-asserted-by":"publisher","first-page":"3873","DOI":"10.1210\/jc.2006-1158","volume":"91","author":"R Nakashima","year":"2006","unstructured":"Nakashima R, Kamei N, Yamane K, Nakanishi S, Nakashima A, Kohno N . Decreased total and high molecular weight adiponectin are independent risk factors for the development of type 2 diabetes in Japanese-Americans. J Clin Endocrinol Metab 2006; 91: 3873\u20133877.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFhr2012141_CR30","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.atherosclerosis.2007.10.002","volume":"199","author":"M von Eynatten","year":"2008","unstructured":"von Eynatten M, Humpert PM, Bluemm A, Lepper PM, Hamann A, Allolio B, Nawroth PP, Bierhaus A, Dugi KA . High-molecular weight adiponectinis independently associated with extent of coronary artery disease in men. Atherosclerosis 2008; 199: 123\u2013128.","journal-title":"Atherosclerosis"},{"key":"BFhr2012141_CR31","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/ajh.2010.198","volume":"24","author":"M Iwai","year":"2011","unstructured":"Iwai M, Kanno H, Inaba S, Senba I, Sone H, Nakaoka H, Nifedipine Horiuchi M . A calcium-channel blocker, attenuated glucose intolerance and white adipose tissue dysfunction in type 2 diabetic KK-A(y) mice. Am J Hypertens 2011; 24: 169\u2013174.","journal-title":"Am J Hypertens"},{"key":"BFhr2012141_CR32","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1038\/hr.2011.129","volume":"34","author":"Z Tian","year":"2011","unstructured":"Tian Z, Miyata K, Tabata M, Yano M, Tazume H, Aoi J, Takahashi O, Araki K, Kawasuji M, Oike Y . Nifedipine increases energy expenditure by increasing PGC-1\u03b1 expression in skeletal muscle. Hypertens Res 2011; 34: 1221\u20131227.","journal-title":"Hypertens Res"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/hr2012141.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr2012141","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr2012141.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:10:24Z","timestamp":1684429824000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/hr2012141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,11]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["BFhr2012141"],"URL":"https:\/\/doi.org\/10.1038\/hr.2012.141","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,11]]}}}