{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:42:57Z","timestamp":1775706177407,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T00:00:00Z","timestamp":1362009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1038\/hr.2012.217","type":"journal-article","created":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T07:04:35Z","timestamp":1362035075000},"page":"414-421","source":"Crossref","is-referenced-by-count":16,"title":["Therapeutic effect of eNOS-transfected endothelial progenitor cells on hemodynamic pulmonary arterial hypertension"],"prefix":"10.1038","volume":"36","author":[{"given":"Lai","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limin","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinqiang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiasi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunsheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,2,28]]},"reference":[{"key":"BFhr2012217_CR1","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.cpcardiol.2011.08.002","volume":"36","author":"VV McLaughlin","year":"2011","unstructured":"McLaughlin VV, Davis M, Cornwell W . Pulmonary arterial hypertension. Curr Probl Cardiol 2011; 36: 461\u2013517.","journal-title":"Curr Probl Cardiol"},{"key":"BFhr2012217_CR2","doi-asserted-by":"publisher","first-page":"13S","DOI":"10.1016\/j.jacc.2004.02.029","volume":"43","author":"M Humbert","year":"2004","unstructured":"Humbert M, Morrell NW, Archer SL, Stenmark KR, MacLean MR, Lang IM, Christman BW, Weir EK, Eickelberg O, Voelkel NF, Rabinovitch M . Cellular and molecular pathobiology of pulmonary arterial hypertension. J Am Coll Cardiol 2004; 43: 13S\u201324S.","journal-title":"J Am Coll Cardiol"},{"key":"BFhr2012217_CR3","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.yjmcc.2007.09.006","volume":"44","author":"SY Chan","year":"2008","unstructured":"Chan SY, Loscalzo J . Pathogenic mechanisms of pulmonary arterial hypertension. J Mol Cell Cardiol 2008; 44: 14\u201330.","journal-title":"J Mol Cell Cardiol"},{"key":"BFhr2012217_CR4","first-page":"542","volume":"57","author":"A Hislop","year":"1976","unstructured":"Hislop A, Reid L . New findings in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension. Br J Exp Pathol 1976; 57: 542\u2013554.","journal-title":"Br J Exp Pathol"},{"key":"BFhr2012217_CR5","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1164\/ajrccm.162.4.9912131","volume":"162","author":"ES Yi","year":"2000","unstructured":"Yi ES, Kim H, Ahn H, Strother J, Morris T, Masliah E, Hansen LA, Park K, Friedman PJ . Distribution of obstructive intimal lesions and their cellular phenotypes in chronic pulmonary hypertension. A morphometric and immunohistochemical study. Am J Respir Crit Care Med 2000; 162: 1577\u20131586.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFhr2012217_CR6","doi-asserted-by":"publisher","first-page":"716.e7","DOI":"10.1016\/j.ahj.2005.07.005","volume":"150","author":"I Schulze-Neick","year":"2005","unstructured":"Schulze-Neick I, Gilbert N, Ewert R, Witt C, Gruenig E, Enke B, Borst MM, Lange PE, Hoeper MM . Adult patients with congenital heart disease and pulmonary arterial hypertension: first open prospective multicenter study of bosentan therapy. Am Heart J 2005; 150: 716.e7\u2013716.e12.","journal-title":"Am Heart J"},{"key":"BFhr2012217_CR7","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.pharmthera.2008.10.002","volume":"121","author":"CJ Rhodes","year":"2009","unstructured":"Rhodes CJ, Davidson A, Gibbs JS, Wharton J, Wilkins MR . Therapeutic targets in pulmonary arterial hypertension. Pharmacol Ther 2009; 121: 69\u201388.","journal-title":"Pharmacol Ther"},{"key":"BFhr2012217_CR8","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/3-540-32967-6_7","volume":"176","author":"S Moncada","year":"2006","unstructured":"Moncada S, Higgs EA . Nitric oxide and the vascular endothelium. Handb Exp Pharmacol 2006; 176: 213\u2013254.","journal-title":"Handb Exp Pharmacol"},{"key":"BFhr2012217_CR9","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.yjmcc.2008.07.015","volume":"45","author":"MT Ziolo","year":"2008","unstructured":"Ziolo MT, Kohr MJ, Wang H . Nitric oxide signaling and the regulation of myocardial function. J Mol Cell Cardiol 2008; 45: 625\u2013632.","journal-title":"J Mol Cell Cardiol"},{"key":"BFhr2012217_CR10","first-page":"7B","volume":"20","author":"JP Cooke","year":"2004","unstructured":"Cooke JP . The pivotal role of nitric oxide for vascular health. Can J Cardiol 2004; 20: 7B\u201315B.","journal-title":"Can J Cardiol"},{"key":"BFhr2012217_CR11","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1042\/bj3570593","volume":"357","author":"WK Alderton","year":"2001","unstructured":"Alderton WK, Cooper CE, Knowles RG . Nitric oxide synthases: structure, function and inhibition. Biochem J 2001; 357: 593\u2013615.","journal-title":"Biochem J"},{"key":"BFhr2012217_CR12","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1152\/physrev.00042.2007","volume":"89","author":"JL Balligand","year":"2009","unstructured":"Balligand JL, Feron O, Dessy C . eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues. Physiol Rev 2009; 89: 481\u2013534.","journal-title":"Physiol Rev"},{"key":"BFhr2012217_CR13","first-page":"H1921","volume":"267","author":"L McQuillan","year":"1994","unstructured":"McQuillan L, Leung G, Marsden P, Kostyk S, Kourembanas S . Hypoxia inhibits expression of eNOS via transcriptional and post-transcriptional mechanisms. Am J Physiol 1994; 267: H1921\u2013H1927.","journal-title":"Am J Physiol"},{"key":"BFhr2012217_CR14","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1056\/NEJM199507273330403","volume":"333","author":"A Giaid","year":"1995","unstructured":"Giaid A, Saleh D . Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med 1995; 333: 214\u2013221.","journal-title":"N Engl J Med"},{"key":"BFhr2012217_CR15","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1172\/JCI3862","volume":"103","author":"KA Fagan","year":"1999","unstructured":"Fagan KA, Fouty BW, Tyler RC, Morris KG, Hepler LK, Sato K, LeCras TD, Abman SH, Weinberger HD, Huang PL, McMurtry IF, Rodman DM . The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive tomild hypoxia. J Clin Invest 1999; 103: 291\u2013299.","journal-title":"J Clin Invest"},{"key":"BFhr2012217_CR16","doi-asserted-by":"publisher","first-page":"13248","DOI":"10.1073\/pnas.182225899","volume":"99","author":"H Champion","year":"2002","unstructured":"Champion H, Bivalacqua T, Greenberg S, Giles T, Hyman A, Kadowitz P . Adenoviral gene transfer of endothelial nitric-oxide synthase (eNOS) partially restores normal pulmonary arterial pressure in eNOS-deficient mice. Proc Natl Acad Sci USA 2002; 99: 13248\u201313253.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFhr2012217_CR17","doi-asserted-by":"publisher","first-page":"S30","DOI":"10.1097\/PCC.0b013e3181c76b42","volume":"11","author":"FE Barr","year":"2010","unstructured":"Barr FE, Macrae D . Inhaled nitric oxide and related therapies. Pediatr Crit Care Med 2010; 11: S30\u2013S36.","journal-title":"Pediatr Crit Care Med"},{"key":"BFhr2012217_CR18","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1146\/annurev.med.56.090203.104149","volume":"56","author":"AY Khakoo","year":"2005","unstructured":"Khakoo AY, Finkel T . Endothelial progenitor cells. Annu Rev Med 2005; 56: 79\u2013101.","journal-title":"Annu Rev Med"},{"key":"BFhr2012217_CR19","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/j.1582-4934.2004.tb00475.x","volume":"8","author":"H Rumpold","year":"2004","unstructured":"Rumpold H, Wolf D, Koeck R, Gunsilius E . Endothelial progenitor cells: a source for therapeutic vasculogenesis? J Cell Mol Med 2004; 8: 509\u2013518.","journal-title":"J Cell Mol Med"},{"key":"BFhr2012217_CR20","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/86498","volume":"7","author":"AA Kocher","year":"2001","unstructured":"Kocher AA, Schuster MD, Szabolcs MJ, Takuma S, Burkhoff D, Wang J, Homma S, Edwards NM, Itescu S . Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 2001; 7: 430\u2013436.","journal-title":"Nat Med"},{"key":"BFhr2012217_CR21","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1161\/01.STR.0000141893.33677.5d","volume":"35","author":"T He","year":"2004","unstructured":"He T, Smith LA, Harrington S, Nath KA, Caplice NM, Katusic ZS . Transplantation of circulating endothelial progenitor cells restores endothelial function of denuded rabbit carotid arteries. Stroke 2004; 35: 2378\u20132384.","journal-title":"Stroke"},{"key":"BFhr2012217_CR22","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1089\/1076327041348563","volume":"10","author":"M Takahashi","year":"2004","unstructured":"Takahashi M, Nakamura T, Toba T, Kajiwara N, Kato H, Shimizu Y . Transplantation of endothelial progenitor cells into the lung to alleviate pulmonary hypertension in dogs. Tissue Eng 2004; 10: 771\u2013779.","journal-title":"Tissue Eng"},{"key":"BFhr2012217_CR23","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1161\/01.RES.0000157672.70560.7b","volume":"96","author":"YD Zhao","year":"2005","unstructured":"Zhao YD, Courtman DW, Deng Y, Kugathasan L, Zhang Q, Stewart DJ . Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease. Circ Res 2005; 96: 442\u2013450.","journal-title":"Circ Res"},{"key":"BFhr2012217_CR24","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1161\/01.RES.00000175934.68087.29","volume":"97","author":"KR Stenmark","year":"2005","unstructured":"Stenmark KR, McMurtry IF . Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension: a time for reappraisal? Circ Res 2005; 97: 95\u201398.","journal-title":"Circ Res"},{"key":"BFhr2012217_CR25","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1164\/rccm.200302-282OC","volume":"169","author":"RT Schermuly","year":"2004","unstructured":"Schermuly RT, Kreisselmeier KP, Ghofrani HA, Yilmaz H, Butrous G, Ermert L, Ermert M, Weissmann N, Rose F, Guenther A, Walmrath D, Seeger W, Grimminger F . Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats. Am J Respir Crit Care Med 2004; 169: 39\u201345.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFhr2012217_CR26","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/S1010-7940(03)00025-3","volume":"23","author":"AF Corno","year":"2003","unstructured":"Corno AF, Tozzi P, Genton CY, von Segesser LK . Surgically induced unilateral pulmonary hypertension: time-related analysis of a new experimental model. Eur J Cardiothorac Surg 2003; 23: 513\u2013517.","journal-title":"Eur J Cardiothorac Surg"},{"key":"BFhr2012217_CR27","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1111\/j.1365-2184.2010.00688.x","volume":"43","author":"W Jianguo","year":"2010","unstructured":"Jianguo W, Tianhang L, Hong Z, Zhengmao L, Jianwei B, Xuchao X, Guoen F . Optimization of culture conditions for endothelial progenitor cells from porcine bone marrow in vitro. Cell Prolif 2010; 43: 418\u2013426.","journal-title":"Cell Prolif"},{"key":"BFhr2012217_CR28","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1183\/09059180.00007910","volume":"19","author":"BJ Mulder","year":"2010","unstructured":"Mulder BJ . Changing demographics of pulmonary arterial hypertension in congenital heart disease. Eur Respir Rev 2010; 19: 308\u2013313.","journal-title":"Eur Respir Rev"},{"key":"BFhr2012217_CR29","doi-asserted-by":"publisher","first-page":"E89","DOI":"10.1161\/01.RES.0000020861.20064.7E","volume":"90","author":"JM Edelberg","year":"2002","unstructured":"Edelberg JM, Tang L, Hattori K, Lyden D, Rafii S . Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function. Circ Res 2002; 90: E89\u2013E93.","journal-title":"Circ Res"},{"key":"BFhr2012217_CR30","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1046\/j.1365-2141.2001.03077.x","volume":"115","author":"N Quirici","year":"2001","unstructured":"Quirici N, Soligo D, Caneva L, Servida F, Bossolasco P, Deliliers GL . Differentiation and expansion of endothelial cells from human bone marrow CD133(+)cells. Br J Haematol 2001; 115: 186\u2013194.","journal-title":"Br J Haematol"},{"key":"BFhr2012217_CR31","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1152\/japplphysiol.00479.2004","volume":"98","author":"TD Le Cras","year":"2005","unstructured":"Le Cras TD, Fernandez LG, Pastura PA, Laubach VE . Vascular growth and remodeling in compensatory lung growth following right lobectomy. J Appl Physiol 2005; 98: 1140\u20131148.","journal-title":"J Appl Physiol"},{"key":"BFhr2012217_CR32","first-page":"L1058","volume":"274","author":"AD Everett","year":"1998","unstructured":"Everett AD, Le Cras TD, Xue C, Johns RA . eNOS expression is not altered in pulmonary vascular remodeling due to increased pulmonary blood flow. Am J Physiol 1998; 274: L1058\u2013L1065.","journal-title":"Am J Physiol"},{"key":"BFhr2012217_CR33","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1161\/01.CIR.0000079161.56080.22","volume":"108","author":"N Nagaya","year":"2003","unstructured":"Nagaya N, Kangawa K, Kanda M, Uematsu M, Horio T, Fukuyama N, Hino J, Harada-Shiba M, Okumura H, Tabata Y, Mochizuki N, Chiba Y, Nishioka K, Miyatake K, Asahara T, Hara H, Mori H . Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells. Circulation 2003; 108: 889\u2013895.","journal-title":"Circulation"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/hr2012217.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr2012217","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr2012217.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:11:10Z","timestamp":1684429870000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/hr2012217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,28]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["BFhr2012217"],"URL":"https:\/\/doi.org\/10.1038\/hr.2012.217","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,28]]}}}