{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:17:25Z","timestamp":1775481445709,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T00:00:00Z","timestamp":1445472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T00:00:00Z","timestamp":1445472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1038\/hr.2015.113","type":"journal-article","created":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T06:06:53Z","timestamp":1445494013000},"page":"95-99","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Combination of serum angiopoietin-2 and uterine artery Doppler for prediction of preeclampsia"],"prefix":"10.1038","volume":"39","author":[{"given":"Ploynin","family":"Puttapitakpong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vorapong","family":"Phupong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,10,22]]},"reference":[{"key":"BFhr2015113_CR1","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/S0140-6736(06)68397-9","volume":"367","author":"KS Khan","year":"2006","unstructured":"Khan KS, Wojdyla D, Say L, Gulmezoglu AM, Van Look PF . WHO analysis of causes of maternal death: a systematic review. Lancet 2006; 367: 1066\u20131074.","journal-title":"Lancet"},{"key":"BFhr2015113_CR2","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1136\/bmj.39335.385301.BE","volume":"335","author":"L Bellamy","year":"2007","unstructured":"Bellamy L, Casas JP, Hingorani AD, Williams DJ . Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ 2007; 335: 974.","journal-title":"BMJ"},{"issue":"Suppl A","key":"BFhr2015113_CR3","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.1016\/j.placenta.2008.11.009","volume":"30","author":"JM Roberts","year":"2009","unstructured":"Roberts JM, Hubel CA . The two stage model of preeclampsia: variations on the theme. Placenta 2009; 30 (Suppl A): S32\u2013S37.","journal-title":"Placenta"},{"key":"BFhr2015113_CR4","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s00404-002-0361-0","volume":"268","author":"V Phupong","year":"2003","unstructured":"Phupong V, Dejthevaporn T, Tanawattanacharoen S, Manotaya S, Tannirandorn Y, Charoenvidhya D . Predicting the risk of preeclampsia and small for gestational age infants by uterine artery Doppler in low-risk women. Arch Gynecol Obstet 2003; 268: 158\u2013161.","journal-title":"Arch Gynecol Obstet"},{"key":"BFhr2015113_CR5","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1097\/GRF.0b013e3181fbb687","volume":"53","author":"TR Lovgren","year":"2010","unstructured":"Lovgren TR, Dugoff L, Galan HL . Uterine artery Doppler and prediction of preeclampsia. Clin Obstet Gynecol 2010; 53: 888\u2013898.","journal-title":"Clin Obstet Gynecol"},{"key":"BFhr2015113_CR6","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1503\/cmaj.070430","volume":"178","author":"JS Cnossen","year":"2008","unstructured":"Cnossen JS, Morris RK, ter Riet G, Mol BW, van der Post JA, Coomarasamy A, Zwinderman AH, Robson SC, Bindels PJ, Kleijnen J, Khan KS . Use of uterine artery Doppler ultrasonography to predict pre-eclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis. CMAJ 2008; 178: 701\u2013711.","journal-title":"CMAJ"},{"key":"BFhr2015113_CR7","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1080\/10641950801958059","volume":"27","author":"V Phupong","year":"2008","unstructured":"Phupong V, Dejthevaporn T . Predicting risks of preeclampsia and small for gestational age infant by uterine artery Doppler. Hypertens Pregnancy 2008; 27: 387\u2013395.","journal-title":"Hypertens Pregnancy"},{"key":"BFhr2015113_CR8","first-page":"1281","volume":"90","author":"S Sritippayawan","year":"2007","unstructured":"Sritippayawan S, Phupong V . Risk assessment of preeclampsia in advanced maternal age by uterine arteries Doppler at 17-21 weeks of gestation. J Med Assoc Thai 2007; 90: 1281\u20131286.","journal-title":"J Med Assoc Thai"},{"key":"BFhr2015113_CR9","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.placenta.2003.10.009","volume":"25","author":"P Kaufmann","year":"2004","unstructured":"Kaufmann P, Mayhew TM, Charnock-Jones DS . Aspects of human fetoplacental vasculogenesis and angiogenesis. II. Changes during normal pregnancy. Placenta 2004; 25: 114\u2013126.","journal-title":"Placenta"},{"key":"BFhr2015113_CR10","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/hr.2014.71","volume":"37","author":"AS Sahay","year":"2014","unstructured":"Sahay AS, Patil VV, Sundrani DP, Joshi AA, Wagh GN, Gupte SA, Joshi SR . A longitudinal study of circulating angiogenic and antiangiogenic factors and AT1-AA levels in preeclampsia. Hypertens Res 2014; 37: 753\u2013758.","journal-title":"Hypertens Res"},{"key":"BFhr2015113_CR11","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/hr.2012.208","volume":"36","author":"K Watanabe","year":"2013","unstructured":"Watanabe K, Mori T, Iwasaki A, Kimura C, Matsushita H, Shinohara K, Wakatsuki A . Increased oxygen free radical production during pregnancy may impair vascular reactivity in preeclamptic women. Hypertens Res 2013; 36: 356\u2013360.","journal-title":"Hypertens Res"},{"key":"BFhr2015113_CR12","doi-asserted-by":"publisher","first-page":"4213","DOI":"10.1210\/jc.2002-020195","volume":"87","author":"E Geva","year":"2002","unstructured":"Geva E, Ginzinger DG, Zaloudek CJ, Moore DH, Byrne A, Jaffe RB . Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2. J Clin Endocrinol Metab 2002; 87: 4213\u20134224.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFhr2015113_CR13","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.amjhyper.2005.03.745","volume":"18","author":"K Hirokoshi","year":"2005","unstructured":"Hirokoshi K, Maeshima Y, Kobayashi K, Matsuura E, Sugiyama H, Yamasaki Y, Masuyama H, Hiramatsu Y, Makino H . Increase of serum angiopoietin-2 during pregnancy is suppressed in women with preeclampsia. Am J Hypertens 2005; 18: 1181\u20131188.","journal-title":"Am J Hypertens"},{"key":"BFhr2015113_CR14","doi-asserted-by":"publisher","first-page":"c43","DOI":"10.1159\/000101483","volume":"106","author":"K Hirokoshi","year":"2007","unstructured":"Hirokoshi K, Maeshima Y, Kobayashi K, Matsuura E, Sugiyama H, Yamasaki Y, Masuyama H, Hiramatsu Y, Makino H . Elevated serum sFlt-1\/Ang-2 ratio in women with preeclampsia. Nephron Clin Pract 2007; 106: c43\u2013c50.","journal-title":"Nephron Clin Pract"},{"key":"BFhr2015113_CR15","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1111\/j.1471-0528.2007.01511.x","volume":"114","author":"Y Wang","year":"2007","unstructured":"Wang Y, Tasevski V, Wallace EM, Gallery ED, Morris JM . Reduced maternal serum concentrations of angiopoietin-2 in the first trimester precede intrauterine growth restriction associated with placental insufficiency. Bjog 2007; 114: 1427\u20131431.","journal-title":"Bjog"},{"key":"BFhr2015113_CR16","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1210\/jc.2009-0715","volume":"95","author":"E Leinonen","year":"2010","unstructured":"Leinonen E, Wathen KA, Alfthan H, Ylikorkala O, Andersson S, Stenman UH, Vuorela P . Maternal serum angiopoietin-1 and -2 and tie-2 in early pregnancy ending in preeclampsia or intrauterine growth retardation. J Clin Endocrinol Metab 2010; 95: 126\u2013133.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFhr2015113_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clp.2010.12.007","volume":"38","author":"MG Tuuli","year":"2011","unstructured":"Tuuli MG, Odibo AO . The role of serum markers and uterine artery Doppler in identifying at-risk pregnancies. Clin Perinatol 2011; 38: 1\u201319 v.","journal-title":"Clin Perinatol"},{"key":"BFhr2015113_CR18","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/hr.2014.27","volume":"37","author":"L Kulmala","year":"2014","unstructured":"Kulmala L, Phupong V . Combination of plasma-soluble fms-like tyrosine kinase 1 and uterine artery Doppler for the prediction of preeclampsia in cases of elderly gravida. Hypertens Res 2014; 37: 538\u2013542.","journal-title":"Hypertens Res"},{"key":"BFhr2015113_CR19","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1097\/OGX.0b013e3182227027","volume":"66","author":"S Kuc","year":"2011","unstructured":"Kuc S, Wortelboer EJ, van Rijn BB, Franx A, Visser GH, Schielen PC . Evaluation of 7 serum biomarkers and uterine artery Doppler ultrasound for first-trimester prediction of preeclampsia: a systematic review. Obstet Gynecol Surv 2011; 66: 225\u2013239.","journal-title":"Obstet Gynecol Surv"},{"key":"BFhr2015113_CR20","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1016\/S0002-9378(98)70160-7","volume":"179","author":"GA Dekker","year":"1998","unstructured":"Dekker GA, Sibai BM . Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol 1998; 179: 1359\u20131375.","journal-title":"Am J Obstet Gynecol"},{"key":"BFhr2015113_CR21","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.ejogrb.2011.12.031","volume":"161","author":"SK Ghosh","year":"2012","unstructured":"Ghosh SK, Raheja S, Tuli A, Raghunandan C, Agarwal S . Combination of uterine artery Doppler velocimetry and maternal serum placental growth factor estimation in predicting occurrence of pre-eclampsia in early second trimester pregnancy: a prospective cohort study. Eur J Obstet Gynecol Reprod Biol 2012; 161: 144\u2013151.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"BFhr2015113_CR22","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1080\/10641950600912968","volume":"25","author":"PR Muller","year":"2006","unstructured":"Muller PR, James AH, Murtha AP, Yonish B, Jamison MG, Dekker G . Circulating angiogenic factors and abnormal uterine artery Doppler velocimetry in the second trimester. Hypertens Pregnancy 2006; 25: 183\u2013192.","journal-title":"Hypertens Pregnancy"},{"key":"BFhr2015113_CR23","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.ijgo.2008.02.016","volume":"102","author":"AE Diab","year":"2008","unstructured":"Diab AE, El-Behery MM, Ebrahiem MA, Shehata AE . Angiogenic factors for the prediction of pre-eclampsia in women with abnormal midtrimester uterine artery Doppler velocimetry. Int J Gynaecol Obstet 2008; 102: 146\u2013151.","journal-title":"Int J Gynaecol Obstet"},{"key":"BFhr2015113_CR24","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1161\/01.HYP.0000258404.21552.a3","volume":"49","author":"H Stepan","year":"2007","unstructured":"Stepan H, Unversucht A, Wessel N, Faber R . Predictive value of maternal angiogenic factors in second trimester pregnancies with abnormal uterine perfusion. Hypertension 2007; 49: 818\u2013824.","journal-title":"Hypertension"},{"key":"BFhr2015113_CR25","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1161\/HYPERTENSIONAHA.108.127977","volume":"53","author":"LC Poon","year":"2009","unstructured":"Poon LC, Kametas NA, Maiz N, Akolekar R, Nicolaides KH . First-trimester prediction of hypertensive disorders in pregnancy. Hypertension 2009; 53: 812\u2013818.","journal-title":"Hypertension"},{"key":"BFhr2015113_CR26","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1097\/OGX.0b013e3182331028","volume":"66","author":"D Raymond","year":"2011","unstructured":"Raymond D, Peterson E . A critical review of early-onset and late-onset preeclampsia. Obstet Gynecol Surv 2011; 66: 497\u2013506.","journal-title":"Obstet Gynecol Surv"},{"key":"BFhr2015113_CR27","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1111\/1471-0528.12128","volume":"120","author":"L Myatt","year":"2013","unstructured":"Myatt L, Clifton R, Roberts J, Spong C, Wapner R, Thorp J Jr, Mercer B, Peaceman A, Ramin S, Carpenter M, Sciscione A, Tolosa J, Saade G, Sorokin Y, Anderson G . Can changes in angiogenic biomarkers between the first and second trimesters of pregnancy predict development of pre-eclampsia in a low-risk nulliparous patient population? BJOG 2013; 120: 1183\u20131191.","journal-title":"BJOG"},{"key":"BFhr2015113_CR28","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1002\/uog.5184","volume":"31","author":"F Crispi","year":"2008","unstructured":"Crispi F, Llurba E, Dominguez C, Martin-Gallan P, Cabero L, Gratacos E . Predictive value of angiogenic factors and uterine artery Doppler for early- versus late-onset pre-eclampsia and intrauterine growth restriction. Ultrasound Obstet Gynecol 2008; 31: 303\u2013309.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"BFhr2015113_CR29","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/hr.2014.62","volume":"37","author":"I Katsipi","year":"2014","unstructured":"Katsipi I, Stylianou K, Petrakis I, Passam A, Vardaki E, Parthenakis F, Makrygiannakis A, Daphnis E, Kyriazis J . The use of pulse wave velocity in predicting pre-eclampsia in high-risk women. Hypertens Res 2014; 37: 733\u2013740.","journal-title":"Hypertens Res"},{"key":"BFhr2015113_CR30","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3109\/10641955.2010.507844","volume":"31","author":"SY Han","year":"2012","unstructured":"Han SY, Jun JK, Lee CH, Park JS, Syn HC . Angiopoietin-2: a promising indicator for the occurrence of severe preeclampsia. Hypertens Pregnancy 2012; 31: 189\u2013199.","journal-title":"Hypertens Pregnancy"},{"key":"BFhr2015113_CR31","doi-asserted-by":"publisher","first-page":"266.e1","DOI":"10.1016\/j.ajog.2008.06.069","volume":"199","author":"MU Baumann","year":"2008","unstructured":"Baumann MU, Bersinger NA, Mohaupt MG, Raio L, Gerber S, Surbek DV . First-trimester serum levels of soluble endoglin and soluble fms-like tyrosine kinase-1 as first-trimester markers for late-onset preeclampsia. Am J Obstet Gynecol 2008; 199: 266.e1\u2013266.e6.","journal-title":"Am J Obstet Gynecol"},{"key":"BFhr2015113_CR32","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1097\/AOG.0b013e3181719b7a","volume":"111","author":"JH Lim","year":"2008","unstructured":"Lim JH, Kim SY, Park SY, Yang JH, Kim MY, Ryu HM . Effective prediction of preeclampsia by a combined ratio of angiogenesis-related factors. Obstet Gynecol 2008; 111: 1403\u20131409.","journal-title":"Obstet Gynecol"},{"key":"BFhr2015113_CR33","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/hr.2014.109","volume":"37","author":"T Tomimatsu","year":"2014","unstructured":"Tomimatsu T, Fujime M, Kanayama T, Mimura K, Koyama S, Kanagawa T, Endo M, Shimoya K, Kimura T . Abnormal pressure-wave reflection in pregnant women with chronic hypertension: association with maternal and fetal outcomes. Hypertens Res 2014; 37: 989\u2013992.","journal-title":"Hypertens Res"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/hr2015113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr2015113","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr2015113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:14:54Z","timestamp":1684430094000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/hr2015113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,22]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["BFhr2015113"],"URL":"https:\/\/doi.org\/10.1038\/hr.2015.113","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,22]]},"assertion":[{"value":"25 February 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}