{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:55:41Z","timestamp":1769846141874,"version":"3.49.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T00:00:00Z","timestamp":1452124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T00:00:00Z","timestamp":1452124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1038\/hr.2015.151","type":"journal-article","created":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T07:01:03Z","timestamp":1452150063000},"page":"312-320","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Augmented circadian rhythm of the intrarenal renin\u2013angiotensin systems in anti-thymocyte serum nephritis rats"],"prefix":"10.1038","volume":"39","author":[{"given":"Shinsuke","family":"Isobe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naro","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayaka","family":"Ishigaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukitoshi","family":"Sakao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Miyajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihide","family":"Fujigaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,1,7]]},"reference":[{"key":"BFhr2015151_CR1","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/BF00340536","volume":"36","author":"M Hilfenhaus","year":"1976","unstructured":"Hilfenhaus M . Circadian rhythm of the renin-angiotensin-aldosterone system in the rat. Arch Toxicol 1976; 36: 305\u2013316.","journal-title":"Arch Toxicol"},{"key":"BFhr2015151_CR2","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1124\/pr.59.3.3","volume":"59","author":"H Kobori","year":"2007","unstructured":"Kobori H, Nangaku M, Navar LG, Nishiyama A . The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev 2007; 59: 251\u2013287.","journal-title":"Pharmacol Rev"},{"key":"BFhr2015151_CR3","first-page":"153","volume":"8","author":"AM Richards","year":"1986","unstructured":"Richards AM, Nicholls MG, Espiner EA, Ikram H, Cullens M, Hinton D . Diurnal patterns of blood pressure, heart rate and vasoactive hormones in normal man. Clin Exp Hypertens A 1986; 8: 153\u2013166.","journal-title":"Clin Exp Hypertens A"},{"key":"BFhr2015151_CR4","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1161\/HYPERTENSIONAHA.110.163519","volume":"57","author":"LG Navar","year":"2011","unstructured":"Navar LG, Kobori H, Prieto MC, Gonzalez-Villalobos RA . Intratubular renin-angiotensin system in hypertension. Hypertension 2011; 57: 355\u2013362.","journal-title":"Hypertension"},{"key":"BFhr2015151_CR5","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1161\/HYPERTENSIONAHA.105.063636","volume":"51","author":"TM Coffman","year":"2008","unstructured":"Coffman TM, Crowley SD . Kidney in hypertension: guyton redux. Hypertension 2008; 51: 811\u2013816.","journal-title":"Hypertension"},{"key":"BFhr2015151_CR6","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1097\/HJH.0b013e328353e807","volume":"30","author":"M Fukuda","year":"2012","unstructured":"Fukuda M, Urushihara M, Wakamatsu T, Oikawa T, Kobori H . Proximal tubular angiotensinogen in renal biopsy suggests nondipper BP rhythm accompanied by enhanced tubular sodium reabsorption. J Hypertens 2012; 30: 1453\u20131459.","journal-title":"J Hypertens"},{"key":"BFhr2015151_CR7","doi-asserted-by":"publisher","first-page":"F953","DOI":"10.1152\/ajprenal.00167.2011","volume":"301","author":"M Fukuda","year":"2011","unstructured":"Fukuda M, Wakamatsu-Yamanaka T, Mizuno M, Miura T, Tomonari T, Kato Y, Ichikawa T, Miyagi S, Shirasawa Y, Ito A, Yoshida A, Kimura G . Angiotensin receptor blockers shift the circadian rhythm of blood pressure by suppressing tubular sodium reabsorption. Am J Physiol Renal Physiol 2011; 301: F953\u2013F957.","journal-title":"Am J Physiol Renal Physiol"},{"key":"BFhr2015151_CR8","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1161\/HYPERTENSIONAHA.108.123802","volume":"53","author":"H Kobori","year":"2009","unstructured":"Kobori H, Alper AB Jr, Shenava R, Katsurada A, Saito T, Ohashi N, Urushihara M, Miyata K, Satou R, Hamm LL, Navar LG . Urinary angiotensinogen as a novel biomarker of the intrarenal renin-angiotensin system status in hypertensive patients. Hypertension 2009; 53: 344\u2013350.","journal-title":"Hypertension"},{"key":"BFhr2015151_CR9","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1161\/01.HYP.0000039960.66987.89","volume":"40","author":"Y Naito","year":"2002","unstructured":"Naito Y, Tsujino T, Fujioka Y, Ohyanagi M, Iwasaki T . Augmented diurnal variations of the cardiac renin-angiotensin system in hypertensive rats. Hypertension 2002; 40: 827\u2013833.","journal-title":"Hypertension"},{"key":"BFhr2015151_CR10","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s10157-014-0973-2","volume":"19","author":"S Isobe","year":"2015","unstructured":"Isobe S, Ohashi N, Fujikura T, Tsuji T, Sakao Y, Yasuda H, Kato A, Miyajima H, Fujigaki Y . Disturbed circadian rhythm of the intrarenal renin-angiotensin system: relevant to nocturnal hypertension and renal damage. Clin Exp Nephrol 2015; 19: 231\u2013239.","journal-title":"Clin Exp Nephrol"},{"key":"BFhr2015151_CR11","doi-asserted-by":"publisher","first-page":"F1512","DOI":"10.1152\/ajprenal.00058.2008","volume":"295","author":"N Ohashi","year":"2008","unstructured":"Ohashi N, Yamamoto T, Huang Y, Misaki T, Fukasawa H, Suzuki H, Togawa A, Suzuki S, Fujigaki Y, Nakagawa T, Nakamura Y, Suzuki F, Kitagawa M, Hishida A . Intrarenal RAS activity and urinary angiotensinogen excretion in anti-thymocyte serum nephritis rats. Am J Physiol Renal Physiol 2008; 295: F1512\u2013F1518.","journal-title":"Am J Physiol Renal Physiol"},{"key":"BFhr2015151_CR12","doi-asserted-by":"publisher","first-page":"F130","DOI":"10.1152\/ajprenal.00275.2011","volume":"303","author":"Y Huang","year":"2012","unstructured":"Huang Y, Yamamoto T, Misaki T, Suzuki H, Togawa A, Ohashi N, Fukasawa H, Fujigaki Y, Ichihara A, Nishiyama A, Senbonmatsu T, Ikegaya N, Hishida A . Enhanced intrarenal receptor-mediated prorenin activation in chronic progression anti-thymocyte serum nephritis rats on high salt intake. Am J Physiol Renal Physiol 2012; 303: F130\u2013F138.","journal-title":"Am J Physiol Renal Physiol"},{"key":"BFhr2015151_CR13","doi-asserted-by":"publisher","first-page":"BR27","DOI":"10.12659\/MSM.881326","volume":"17","author":"SA Hosgood","year":"2011","unstructured":"Hosgood SA, Mohamed IH, Nicholson ML . The two layer method does not improve the preservation of porcine kidneys. Med Sci Monit 2011; 17: BR27\u2013BR33.","journal-title":"Med Sci Monit"},{"key":"BFhr2015151_CR14","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/j.1523-1755.2004.00393.x","volume":"65","author":"H Fukasawa","year":"2004","unstructured":"Fukasawa H, Yamamoto T, Suzuki H, Togawa A, Ohashi N, Fujigaki Y, Uchida C, Aoki M, Hosono M, Kitagawa M, Hishida A . Treatment with anti-TGF-\u03b2 antibody ameliorates chronic progressive nephritis by inhibiting smad\/TGF-\u03b2 signalling. Kidney Int 2004; 65: 63\u201374.","journal-title":"Kidney Int"},{"key":"BFhr2015151_CR15","doi-asserted-by":"publisher","first-page":"F1257","DOI":"10.1152\/ajprenal.00588.2007","volume":"294","author":"H Kobori","year":"2008","unstructured":"Kobori H, Katsurada A, Miyata K, Ohashi N, Satou R, Saito T, Hagiwara Y, Miyashita K, Navar LG . Determination of plasma and urinary angiotensinogen levels in rodents by newly developed ELISA. Am J Phisiol Renal Physiol 2008; 294: F1257\u2013F1263.","journal-title":"Am J Phisiol Renal Physiol"},{"key":"BFhr2015151_CR16","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1681\/ASN.2004080676","volume":"16","author":"H Kobori","year":"2005","unstructured":"Kobori H, Ozawa Y, Suzuki Y, Nishiyama A . Enhanced intrarenal angiotensinogen contributes to early renal injury in spontaneously hypertensive rats. J Am Soc Nephrol 2005; 16: 2073\u20132080.","journal-title":"J Am Soc Nephrol"},{"key":"BFhr2015151_CR17","doi-asserted-by":"publisher","first-page":"3176","DOI":"10.1093\/ndt\/gfs011","volume":"27","author":"KT Mills","year":"2012","unstructured":"Mills KT, Kobori H, Hamm LL, Alper AB, Khan IE, Rahman M, Navar LG, Liu Y, Browne GM, Batuman V, He J, Chen J . Increased urinary excretion of angiotensinogen is associated with risk of chronic kidney disease. Nephrol Dial Transplant 2012; 27: 3176\u20133181.","journal-title":"Nephrol Dial Transplant"},{"key":"BFhr2015151_CR18","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/BF01468789","volume":"54","author":"D Lommer","year":"1976","unstructured":"Lommer D, Distler A, Nast HP, Sinterhauf K, Walter U, Wolff HP, Sieler K . Diurnal profiles of plasma aldosterone, cortisol, renin, angiotensinogen and angiotensinases in normal subjects. Klin Wochenschr 1976; 54: 123\u2013130.","journal-title":"Klin Wochenschr"},{"key":"BFhr2015151_CR19","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1177\/1470320314557584","volume":"15","author":"Y Nishijima","year":"2014","unstructured":"Nishijima Y, Kobori H, Kaifu K, Mizushige T, Hara T, Nishiyama A, Kohno M . Circadian rhythm of plasma and urinary angiotensinogen in healthy volunteers and in patients with chronic kidney disease. J Renin Angiotensin Aldosterone Syst 2014; 15: 505\u2013508.","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"BFhr2015151_CR20","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1097\/01.ASN.0000131528.00773.A9","volume":"15","author":"ML Graciano","year":"2004","unstructured":"Graciano ML, Cavaglieri Rde C, Dell\u00e9 H, Dominguez WV, Casarini DE, Malheiros DM, Noronha IL . Intrarenal renin-angiotensin system is upregulated in experimental model of progressive renal disease induced by chronic inhibition of nitric oxide synthesis. J Am Soc Nephrol 2004; 15: 1805\u20131815.","journal-title":"J Am Soc Nephrol"},{"key":"BFhr2015151_CR21","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1172\/JCI65460","volume":"123","author":"RA Gonzalez-Villalobos","year":"2013","unstructured":"Gonzalez-Villalobos RA, Janjoulia T, Fletcher NK, Giani JF, Nguyen MT, Riquier-Brison AD, Seth DM, Fuchs S, Eladari D, Picard N, Bachmann S, Delpire E, Peti-Peterdi J, Navar LG, Bernstein KE, McDouough AA . The absence of intrarenal ACE protects against hypertension. J Clin Invest 2013; 123: 2011\u20132023.","journal-title":"J Clin Invest"},{"key":"BFhr2015151_CR22","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1111\/j.1523-1755.2004.00419.x","volume":"65","author":"M Fukuda","year":"2004","unstructured":"Fukuda M, Munemura M, Usami T, Nakao N, Takeushi O, Kamiya Y, Yoshida A, Kimura G . Nocturnal blood pressure is elevated with natriuresis and proteinuria as renal function deteriorates in nephropathy. Kidney Int 2004; 65: 621\u2013625.","journal-title":"Kidney Int"},{"key":"BFhr2015151_CR23","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1159\/000065274","volume":"22","author":"M Nishimura","year":"2002","unstructured":"Nishimura M, Uzu T, Fujii T, Kimura G . Disturbed circadian rhythm of urinary albumin excretion in non-dipper type of essential hypertension. Am J Nephrol 2002; 22: 455\u2013462.","journal-title":"Am J Nephrol"},{"key":"BFhr2015151_CR24","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.jash.2008.04.008","volume":"2","author":"H Kobori","year":"2008","unstructured":"Kobori H, Ohashi N, Katsurada A, Miyata K, Satou R, Saito T, Yamamoto T . Urinary angiotensinogen as a potential biomarker of severity of chronic renal disease. J Am Soc Hypertens 2008; 2: 349\u2013354.","journal-title":"J Am Soc Hypertens"},{"key":"BFhr2015151_CR25","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1161\/01.HYP.0000050102.90932.CF","volume":"41","author":"H Kobori","year":"2003","unstructured":"Kobori H, Nishiyama A, Harrison-Bernard LM, Navar LG . Urinary angiotensinogen as an indicator of intrarenal angiotensin status in hypertension. Hypertension 2003; 41: 42\u201349.","journal-title":"Hypertension"},{"key":"BFhr2015151_CR26","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1681\/ASN.2011121159","volume":"23","author":"T Matsusaka","year":"2012","unstructured":"Matsusaka T, Niimura F, Shimizu A, Pastan I, Saito A, Kobori H, Nishiyama A, Ichikawa I . Liver angiotensinogen is the primary source of renal angiotensin II. J Am Soc Nephrol 2012; 23: 1181\u20131189.","journal-title":"J Am Soc Nephrol"},{"key":"BFhr2015151_CR27","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1172\/JCI112013","volume":"76","author":"S Anderson","year":"1985","unstructured":"Anderson S, Meyer TW, Rennke HG, Brenner BM . Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass. J Clin Invest 1985; 76: 612\u2013619.","journal-title":"J Clin Invest"},{"key":"BFhr2015151_CR28","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/ki.1982.143","volume":"22","author":"JL Olson","year":"1982","unstructured":"Olson JL, Hostetter TH, Rennke HG, Brenner BM, Venkatachalam MA . Altered glomerular permselectivity and progression sclerosis following extreme ablation of renal mass. Kidney Int 1982; 22: 112\u2013126.","journal-title":"Kidney Int"},{"key":"BFhr2015151_CR29","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1038\/ki.2013.453","volume":"85","author":"T Matsusaka","year":"2014","unstructured":"Matsusaka T, Niimura F, Pastan I, Shintani A, Nishiyama A, Ichikawa I . Podocyte injury enhances filtration of liver-derived angiotensinogen and renal angiotensin II generation. Kidney Int 2014; 85: 1068\u20131077.","journal-title":"Kidney Int"},{"key":"BFhr2015151_CR30","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.coph.2011.01.009","volume":"11","author":"LG Navar","year":"2011","unstructured":"Navar LG, Prieto MC, Satou R, Kobori H . Intrarenal angiotensin II and its contribution to the genesis of chronic hypertension. Curr Opin Pharmacol 2011; 11: 180\u2013186.","journal-title":"Curr Opin Pharmacol"},{"key":"BFhr2015151_CR31","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1172\/JCI117886","volume":"95","author":"HF Cheng","year":"1995","unstructured":"Cheng HF, Becker BN, Burns KD, Harris RC . Angiotensin II upregulates type-1 angiotensin II receptors in renal proximal tubule. J Clin Invest 1995; 95: 2012\u20132019.","journal-title":"J Clin Invest"},{"key":"BFhr2015151_CR32","doi-asserted-by":"publisher","first-page":"F19","DOI":"10.1152\/ajprenal.0335.2000","volume":"282","author":"LM Harrison-Bernard","year":"2002","unstructured":"Harrison-Bernard LM, Zhuo J, Kobori H, Ohishi M, Navar LG . Intrarenal AT(1) receptor and ACE binding in ANG II-induced hypertensive rats. Am J Physiol Renal Physiol 2002; 282: F19\u2013F25.","journal-title":"Am J Physiol Renal Physiol"},{"key":"BFhr2015151_CR33","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1681\/ASN.2014050518","volume":"26","author":"W Cao","year":"2015","unstructured":"Cao W, Li A, Wang L, Zhou Z, Su Z, Bin W, Wilcox CS, Hou FF . A salt-induced reno-cerebral reflex activates renin-angiotensin systems and promotes CKD progression. J Am Soc Nephrol 2015; 26: 1619\u20131633.","journal-title":"J Am Soc Nephrol"},{"key":"BFhr2015151_CR34","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1001\/jama.288.19.2421","volume":"288","author":"JT Wright Jr","year":"2002","unstructured":"Wright JT Jr, Bakris G, Greene T, Agodoa LY, Appel LJ, Cheek D, Douglas-Baltimore JG, Gassman J, Glassock R, Hebert L, Jamerson K, Lewis J, Phillips RA, Toto RD, Middleton JP, Rostand SG . Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial. JAMA 2002; 288: 2421\u20132431.","journal-title":"JAMA"},{"key":"BFhr2015151_CR35","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/hr.2014.79","volume":"37","author":"L Ho\u0161kov\u00e1","year":"2014","unstructured":"Ho\u0161kov\u00e1 L, M\u00e1lek I, Kautzner J, Honsov\u00e1 E, van Dokkum RP, Huskov\u00e1 Z, Vojt\u00ed\u0161kov\u00e1 A, Varcabov\u00e1 S, Cervenka L, Kopkan L . Tacrolimus-induced hypertension and nephrotoxicity in Fawn-Hooded rats are attenuated by dual inhibition of renin-angiotensin system. Hypertens Res 2014; 37: 724\u2013732.","journal-title":"Hypertens Res"},{"key":"BFhr2015151_CR36","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/hr.2013.121","volume":"37","author":"P Gosse","year":"2014","unstructured":"Gosse P, Schumacher H . Effect of telmisartan vs ramipril on 'dipping' status and blood pressure variability: pooled analysis of the PRISMA studies. Hypertens Res 2014; 37: 151\u2013157.","journal-title":"Hypertens Res"},{"key":"BFhr2015151_CR37","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1172\/JCI118125","volume":"96","author":"KA Griffin","year":"1995","unstructured":"Griffin KA, Picken MM, Bidani AK . Deleterious effects of calcium channel blocker on pressure transmission and gromerular injury in rat remnant kidneys. J Clin Invest 1995; 96: 793\u2013800.","journal-title":"J Clin Invest"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/hr2015151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr2015151","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr2015151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:15:13Z","timestamp":1684430113000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/hr2015151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,7]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["BFhr2015151"],"URL":"https:\/\/doi.org\/10.1038\/hr.2015.151","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,7]]},"assertion":[{"value":"14 July 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}