{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:29:49Z","timestamp":1792672189010,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T00:00:00Z","timestamp":1452729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T00:00:00Z","timestamp":1452729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1038\/hr.2015.153","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T12:35:19Z","timestamp":1452774919000},"page":"302-311","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Reversal of right ventricular remodeling by dichloroacetate is related to inhibition of mitochondria-dependent apoptosis"],"prefix":"10.1038","volume":"39","author":[{"given":"Xiao-Qing","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Da","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin-Hua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harm","family":"Jan Bogaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Cheng","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,1,14]]},"reference":[{"key":"BFhr2015153_CR1","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1161\/ATVBAHA.114.303320","volume":"34","author":"S Ikeda","year":"2014","unstructured":"Ikeda S, Satoh K, Kikuchi N, Miyata S, Suzuki K, Omura J, Shimizu T, Kobayashi K, Kobayashi K, Fukumoto Y, Sakata Y, Shimokawa H . Crucial role of Rho-kinase in pressure overload-induced right ventricular hypertrophy and dysfunction in mice. Arterioscler Thromb Vasc Biol 2014; 34: 1260\u20131271.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BFhr2015153_CR2","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1093\/eurheartj\/ehl477","volume":"28","author":"SA van Wolferen","year":"2007","unstructured":"van Wolferen SA, Marcus JT, Boonstra A, Marques KM, Bronzwaer JG, Spreeuwenberg MD, Postmus PE, Vonk-Noordegraaf A . Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension. Eur Heart J 2007; 28: 1250\u20131257.","journal-title":"Eur Heart J"},{"key":"BFhr2015153_CR3","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1161\/CIRCULATIONAHA.109.883843","volume":"120","author":"HJ Bogaard","year":"2009","unstructured":"Bogaard HJ, Natarajan R, Henderson SC, Long CS, Kraskauskas D, Smithson L, Ockaili R, McCord JM, Voelkel NF . Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure. Circulation 2009; 120: 1951\u20131960.","journal-title":"Circulation"},{"key":"BFhr2015153_CR4","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.2967\/jnumed.108.061366","volume":"50","author":"ME Campian","year":"2009","unstructured":"Campian ME, Verberne HJ, Hardziyenka M, de Bruin K, Selwaness M, van den Hoff MJ, Ruijter JM, van Eck-Smit BL, de Bakker JM, Tan HL . Serial noninvasive assessment of apoptosis during right ventricular disease progression in rats. J Nucl Med 2009; 50: 1371\u20131377.","journal-title":"J Nucl Med"},{"key":"BFhr2015153_CR5","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1093\/cvr\/cvn243","volume":"81","author":"GW Dorn","year":"2008","unstructured":"Dorn GW . Apoptotic and non-apoptotic programmed cardiomyocyte death in ventricular remodelling. Cardiovasc Res 2008; 81: 465\u2013473.","journal-title":"Cardiovasc Res"},{"key":"BFhr2015153_CR6","doi-asserted-by":"publisher","first-page":"e44485","DOI":"10.1371\/journal.pone.0044485","volume":"7","author":"XR Zuo","year":"2012","unstructured":"Zuo XR, Wang Q, Cao Q, Yu YZ, Wang H, Bi LQ, Xie WP, Wang H . Nicorandil prevents right ventricular remodeling by inhibiting apoptosis and lowering pressure overload in rats with pulmonary arterial hypertension. PLoS ONE 2012; 7: e44485.","journal-title":"PLoS ONE"},{"key":"BFhr2015153_CR7","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1164\/rccm.201003-0335OC","volume":"182","author":"HJ Bogaard","year":"2010","unstructured":"Bogaard HJ, Natarajan R, Mizuno S, Abbate A, Chang PJ, Chau VQ, Hoke NN, Kraskauskas D, Kasper M, Salloum FN, Voelkel NF . Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats. Am J Respir Cirt Care Med 2010; 182: 652\u2013660.","journal-title":"Am J Respir Cirt Care Med"},{"key":"BFhr2015153_CR8","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/S0968-0004(01)01844-8","volume":"26","author":"C Adrain","year":"2001","unstructured":"Adrain C, Martin SJ . The mitochondrial apoptosome: a killer unleashed by the cytochrome seas. Trends Biochem Sci 2001; 26: 390\u2013397.","journal-title":"Trends Biochem Sci"},{"key":"BFhr2015153_CR9","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s00109-012-0982-0","volume":"91","author":"L Piao","year":"2013","unstructured":"Piao L, Sidhu VK, Fang YH, Ryan JJ, Parikh KS, Hong Z, Toth PT, Morrow E, Kutty S, Lopaschuk GD, Archer SL . FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate. J Mol Med (Berl) 2013; 91: 333\u2013346.","journal-title":"J Mol Med (Berl)"},{"key":"BFhr2015153_CR10","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00109-009-0524-6","volume":"88","author":"L Piao","year":"2010","unstructured":"Piao L, Fang YH, Cadete VJ, Wietholt C, Urboniene D, Toth PT, Marsboom G, Zhang HJ, Haber I, Rehman J, Lopaschuk GD, Archer SL . The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle. J Mol Med (Berl) 2010; 88: 47\u201360.","journal-title":"J Mol Med (Berl)"},{"key":"BFhr2015153_CR11","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1161\/CIRCHEARTFAILURE.111.966127","volume":"6","author":"J Gomez-Arroyo","year":"2013","unstructured":"Gomez-Arroyo J, Mizuno S, Szczepanek K, Van Tassell B, Natarajan R, dos Remedios CG, Drake JI, Farkas L, Kraskauskas D, Wijesinghe DS, Chalfant CE, Bigbee J, Abbate A, Lesnefsky EJ, Bogaard HJ, Voelkel NF . Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy due to pulmonary arterial hypertension. Circ Heart Fail 2013; 6: 136\u2013144.","journal-title":"Circ Heart Fail"},{"key":"BFhr2015153_CR12","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1042\/bj3520731","volume":"352","author":"MC Sugden","year":"2000","unstructured":"Sugden MC, Langdown ML, Harris RA, Holness MJ . Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply. Biochem J 2000; 352: 731\u2013738.","journal-title":"Biochem J"},{"key":"BFhr2015153_CR13","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1056\/NEJMra063052","volume":"356","author":"S Neubauer","year":"2007","unstructured":"Neubauer S . The failing heart\u2014an engine out of fuel. N Engl J Med 2007; 356: 1140\u20131151.","journal-title":"N Engl J Med"},{"key":"BFhr2015153_CR14","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/0026-0495(89)90051-6","volume":"38","author":"PW Stacpoole","year":"1989","unstructured":"Stacpoole PW . The pharmacology of dichloroacetate. Metabolism 1989; 38: 1124\u20131144.","journal-title":"Metabolism"},{"key":"BFhr2015153_CR15","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1007\/s00109-010-0679-1","volume":"88","author":"L Piao","year":"2010","unstructured":"Piao L, Marsboom G, Archer SL . Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure. J Mol Med (Berl) 2010; 88: 1011\u20131020.","journal-title":"J Mol Med (Berl)"},{"key":"BFhr2015153_CR16","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1172\/JCI27794","volume":"116","author":"BN Finck","year":"2006","unstructured":"Finck BN, Kelly DP . PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest 2006; 116: 615\u2013622.","journal-title":"J Clin Invest"},{"key":"BFhr2015153_CR17","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1161\/01.RES.0000145360.16770.9f","volume":"95","author":"MS McMurtry","year":"2004","unstructured":"McMurtry MS, Bonnet S, Wu X, Dyck JR, Haromy A, Hashimoto K, Michelakis ED . Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res 2004; 95: 830\u2013840.","journal-title":"Circ Res"},{"key":"BFhr2015153_CR18","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1161\/CIRCHEARTFAILURE.109.888479","volume":"3","author":"T Kato","year":"2010","unstructured":"Kato T, Niizuma S, Inuzuka Y, Kawashima T, Okuda J, Tamaki Y, Iwanaga Y, Narazaki M, Matsuda T, Soga T, Kita T, Kimura T, Shioi T . Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure. Circ Heart Fail 2010; 3: 420\u2013430.","journal-title":"Circ Heart Fail"},{"key":"BFhr2015153_CR19","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/hr.2013.129","volume":"37","author":"Q Guo","year":"2014","unstructured":"Guo Q, Huang JA, Yamamura A, Yamamura H, Zimnicka AM, Fernandez R, Yuan JX . Inhibition of the Ca(2+)-sensing receptor rescues pulmonary hypertension in rats and mice. Hypertens Res 2014; 37: 116\u2013124.","journal-title":"Hypertens Res"},{"key":"BFhr2015153_CR20","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/76282","volume":"6","author":"KN Cowan","year":"2000","unstructured":"Cowan KN, Heilbut A, Humpl T, Lam C, Ito S, Rabinovitch M . Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Nat Med 2000; 6: 698\u2013702.","journal-title":"Nat Med"},{"key":"BFhr2015153_CR21","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1093\/cvr\/cvu010","volume":"101","author":"M Ricke-Hoch","year":"2014","unstructured":"Ricke-Hoch M, Bultmann I, Stapel B, Condorelli G, Rinas U, Sliwa K, Scherr M, Hilfiker-Kleiner D . Opposing roles of Akt and STAT3 in the protection of the maternal heart from peripartum stress. Cardiovasc Res 2014; 101: 587\u2013596.","journal-title":"Cardiovasc Res"},{"key":"BFhr2015153_CR22","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1016\/j.ijcard.2013.01.006","volume":"168","author":"J Li","year":"2013","unstructured":"Li J, Zhang DS, Ye JC, Li CM, Qi M, Liang DD, Xu XR, Xu L, Liu Y, Zhang H, Zhang YY, Deng FF, Feng J, Shi D, Chen JJ, Li L, Chen G, Sun YF, Peng LY, Chen YH . Dynamin-2 mediates heart failure by modulating Ca2+-dependent cardiomyocyte apoptosis. Int J Cardiol 2013; 168: 2109\u20132119.","journal-title":"Int J Cardiol"},{"key":"BFhr2015153_CR23","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s10495-011-0590-4","volume":"16","author":"I Sinha-Hikim","year":"2011","unstructured":"Sinha-Hikim I, Shen R, Nzenwa I, Gelfand R, Mahata SK, Sinha-Hikim AP . Minocycline suppresses oxidative stress and attenuates fetal cardiac myocyte apoptosis triggered by in utero cocaine exposure. Apoptosis 2011; 16: 563\u2013573.","journal-title":"Apoptosis"},{"key":"BFhr2015153_CR24","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.ymgme.2004.06.009","volume":"83","author":"BA Barshop","year":"2004","unstructured":"Barshop BA, Naviaux RK, McGowan KA, Levine F, Nyhan WL, Loupis-Geller A, Haas RH . Chronic treatment of mitochondrial disease patients with dichloroacetate. Mol Genet Metab 2004; 83: 138\u2013149.","journal-title":"Mol Genet Metab"},{"key":"BFhr2015153_CR25","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","volume":"22","author":"S Reagan-Shaw","year":"2008","unstructured":"Reagan-Shaw S, Nihal M, Ahmad N . Dose translation from animal to human studies revisited. FASEB J 2008; 22: 659\u2013661.","journal-title":"FASEB J"},{"key":"BFhr2015153_CR26","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00109-011-0804-9","volume":"90","author":"YH Fang","year":"2012","unstructured":"Fang YH, Piao L, Hong Z, Toth PT, Marsboom G, Bache-Wiig P, Rehman J, Archer SL . Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle's cycle. J Mol Med (Berl) 2012; 90: 31\u201343.","journal-title":"J Mol Med (Berl)"},{"key":"BFhr2015153_CR27","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.cmet.2006.02.002","volume":"3","author":"JW Kim","year":"2006","unstructured":"Kim JW, Tchernyshyov I, Semenza GL, Dang CV . HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006; 3: 177\u2013185.","journal-title":"Cell Metab"},{"key":"BFhr2015153_CR28","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1164\/rccm.201108-1562OC","volume":"185","author":"G Marsboom","year":"2012","unstructured":"Marsboom G, Wietholt C, Haney CR, Toth PT, Ryan JJ, Morrow E, Thenappan T, Bache-Wiig P, Piao L, Paul J, Chen CT, Archer SL . Lung (1)(8)F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension. Am J Respir Crit Care Med 2012; 185: 670\u2013679.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFhr2015153_CR29","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1093\/cvr\/cvn280","volume":"81","author":"H Tsutsui","year":"2009","unstructured":"Tsutsui H, Kinugawa S, Matsushima S . Mitochondrial oxidative stressand dysfunction in myocardial remodelling. Cardiovasc Res 2009; 81: 449\u2013456.","journal-title":"Cardiovasc Res"},{"key":"BFhr2015153_CR30","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/hr.2013.146","volume":"37","author":"JQ Rodrigues","year":"2014","unstructured":"Rodrigues JQ, da Silva ED Jr, de Magalh\u00e3es Galv\u00e3o K, Miranda-Ferreira R, Caricati-Neto A, Jurkiewicz NH, Garcia AG, Jurkiewicz A . Differential regulation of atrial contraction by P1 and P2 purinoceptors in normotensive and spontaneously hypertensive rats. Hypertens Res 2014; 37: 210\u2013219.","journal-title":"Hypertens Res"},{"key":"BFhr2015153_CR31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/HCO.0b013e328335febd","volume":"25","author":"F Haddad","year":"2010","unstructured":"Haddad F, Ashley E, Michelakis ED . New insights for the diagnosis and management of right ventricular failure, from molecular imaging to targeted right ventricular therapy. Curr Opin Cardiol 2010; 25: 131\u2013140.","journal-title":"Curr Opin Cardiol"},{"key":"BFhr2015153_CR32","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1002\/pbc.25348","volume":"62","author":"EJ Rellinger","year":"2015","unstructured":"Rellinger EJ, Romain C, Choi S, Qiao J, Chung DH . Silencing gastrin-releasing peptide receptor suppresses key regulators of aerobic glycolysis in neuroblastoma cells. Pediatr Blood Cancer 2015; 62: 581\u2013586.","journal-title":"Pediatr Blood Cancer"},{"key":"BFhr2015153_CR33","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1161\/01.RES.83.1.15","volume":"83","author":"MH Soonpaa","year":"1998","unstructured":"Soonpaa MH, Field LJ . Survey of studies examining mammalian cardiomyocyte DNA synthesis. Circ Res 1998; 83: 15\u201326.","journal-title":"Circ Res"},{"key":"BFhr2015153_CR34","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1161\/01.CIR.0000051865.66123.B7","volume":"107","author":"S Hein","year":"2003","unstructured":"Hein S, Arnon E, Kostin S, Sch\u00f6nburg M, Els\u00e4sser A, Polyakova V, Bauer EP, Kl\u00f6vekorn WP, Schaper J . Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms. Circulation 2003; 107: 984\u2013991.","journal-title":"Circulation"},{"key":"BFhr2015153_CR35","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1056\/NEJM199704173361603","volume":"336","author":"G Olivetti","year":"1997","unstructured":"Olivetti G, Abbi R, Quaini F, Kajstura J, Cheng W, Nitahara JA, Quaini E, Di Loreto C, Beltrami CA, Krajewski S, Reed JC, Anversa P . Apoptosis in the failing human heart. N Engl J Med 1997; 336: 1131\u20131141.","journal-title":"N Engl J Med"},{"key":"BFhr2015153_CR36","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1161\/01.RES.86.11.1107","volume":"86","author":"PM Kang","year":"2000","unstructured":"Kang PM, Izumo S . Apoptosis and heart failure: a critical review of the literature. Circ Res 2000; 86: 1107\u20131113.","journal-title":"Circ Res"},{"key":"BFhr2015153_CR37","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/S0024-3205(99)00322-7","volume":"65","author":"S Ikeda","year":"1999","unstructured":"Ikeda S, Hamada M, Hiwada K . Cardiomyocyte apoptosis with enhanced expression of P53 and Bax in right ventricle after pulmonary arterial banding. Life Sci 1999; 65: 925\u2013933.","journal-title":"Life Sci"},{"key":"BFhr2015153_CR38","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/S0008-6363(03)00470-X","volume":"59","author":"MU Braun","year":"2003","unstructured":"Braun MU, Szalai P, Strasser RH, Borst MM . Right ventricular hypertrophy and apoptosis after pulmonary artery banding: regulation of PKC isozymes. Cardiovasc Res 2003; 59: 658\u2013667.","journal-title":"Cardiovasc Res"},{"key":"BFhr2015153_CR39","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1172\/JCI17664","volume":"111","author":"D Wencker","year":"2003","unstructured":"Wencker D, Chandra M, Nguyen K, Miao W, Garantziotis S, Factor SM, Shirani J, Armstrong RC, Kitsis RN . A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest 2003; 111: 1497\u20131504.","journal-title":"J Clin Invest"},{"key":"BFhr2015153_CR40","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1161\/hc0402.102863","volume":"105","author":"S Hirotani","year":"2002","unstructured":"Hirotani S, Otsu K, Nishida K, Higuchi Y, Morita T, Nakayama H, Yamaguchi O, Mano T, Matsumura Y, Ueno H, Tada M, Hori M . Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy. Circulation 2002; 105: 509\u2013515.","journal-title":"Circulation"},{"key":"BFhr2015153_CR41","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1080\/15216540152846046","volume":"52","author":"A Gross","year":"2001","unstructured":"Gross A . BCL-2 proteins: regulators of the mitochondrial apoptotic program. IUBMB Life 2001; 52: 231\u2013236.","journal-title":"IUBMB Life"},{"key":"BFhr2015153_CR42","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1126\/science.281.5381.1322","volume":"281","author":"JM Adams","year":"1998","unstructured":"Adams JM, Cory S . The Bcl-2 protein family: arbiters of cell survival. Science 1998; 281: 1322\u20131326.","journal-title":"Science"},{"key":"BFhr2015153_CR43","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1016\/j.freeradbiomed.2008.01.011","volume":"44","author":"B Liu","year":"2008","unstructured":"Liu B, Chen Y, Clair. DK St . ROS and p53: a versatile partnership. Free Radic Biol Med 2008; 44: 1529\u20131535.","journal-title":"Free Radic Biol Med"},{"key":"BFhr2015153_CR44","doi-asserted-by":"publisher","first-page":"13294","DOI":"10.1074\/jbc.M208670200","volume":"278","author":"EK Pias","year":"2003","unstructured":"Pias EK, Ekshyyan OY, Rhoads CA, Fuseler J, Harrison L, Aw TY . Differential effects of superoxide dismutase isoform expression on hydroperoxide-induced apoptosis in PC-12 cells. J Biol Chem 2003; 278: 13294\u201313301.","journal-title":"J Biol Chem"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/hr2015153.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr2015153","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr2015153.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:15:14Z","timestamp":1684430114000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/hr2015153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,14]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["BFhr2015153"],"URL":"https:\/\/doi.org\/10.1038\/hr.2015.153","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,14]]},"assertion":[{"value":"8 July 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Z-CJ has acted as a consultant to and a member of scientific advisory boards for companies including Actelion, Bayer Schering, Pfizer and United Therapeutics, in addition to working as an investigator in trials involving these companies. The remaining authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}