{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:24:23Z","timestamp":1783365863343,"version":"3.54.6"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T00:00:00Z","timestamp":1469059200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T00:00:00Z","timestamp":1469059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1038\/hr.2016.91","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T06:13:24Z","timestamp":1469081604000},"page":"681-687","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Clock genes and salt-sensitive hypertension: a new type of aldosterone-synthesizing enzyme controlled by the circadian clock and angiotensin II"],"prefix":"10.1038","volume":"39","author":[{"given":"Hitoshi","family":"Okamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Doi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rika","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,21]]},"reference":[{"key":"BFhr201691_CR1","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/hr.2012.26","volume":"35","author":"Y Yano","year":"2012","unstructured":"Yano Y, Kario K . Nocturnal blood pressure and cardiovascular disease: a review of recent advances. Hypertens Res 2012; 35: 695\u2013701.","journal-title":"Hypertens Res"},{"key":"BFhr201691_CR2","doi-asserted-by":"publisher","first-page":"4453","DOI":"10.1073\/pnas.0808180106","volume":"106","author":"FA Scheer","year":"2009","unstructured":"Scheer FA, Hilton MF, Mantzoros CS, Shea SA . Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci USA 2009; 106: 4453\u20134458.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFhr201691_CR3","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/nm.2061","volume":"16","author":"M Doi","year":"2010","unstructured":"Doi M, Takahashi Y, Komatsu R, Yamazaki F, Yamada H, Haraguchi S, Emoto N, Okuno Y, Tsujimoto G, Kanematsu A, Ogawa O, Todo T, Tsutsui K, van der Horst GTJ, Okamura H . Salt-sensitive hypertension in circadian clock-deficient mice involves dysregulated adrenal Hsd3b6. Nature Med 2010; 16: 67\u201374.","journal-title":"Nature Med"},{"key":"BFhr201691_CR4","doi-asserted-by":"publisher","first-page":"E257","DOI":"10.1210\/jc.2013-3279","volume":"99","author":"M Doi","year":"2014","unstructured":"Doi M, Satoh F, Maekawa T, Nakamura Y, Fustin JM, Tainaka M, Hotta Y, Takahashi Y, Morimoto R, Takase K, Ito S, Sasano H, Okamura H . Isoform-specific monoclonal antibodies against 3\u03b2-hydroxysteroid dehydrogenase\/isomerase family provide markers for subclassification of human primary aldosteronism. J Clin Endocrinol Metab 2014; 99: E257\u2013E262.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFhr201691_CR5","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.mce.2014.10.008","volume":"408","author":"S Konosu-Fukaya","year":"2015","unstructured":"Konosu-Fukaya S, Nakamura Y, Satoh F, Ono Y, Felizola SJ, Ise K, Maekawa T, Takeda K, Katsu K, Fujishima F, Kasajima A, Watanabe M, Arai Y, Gomez-Sanchez EP, Gomez-Sanchez CE, Doi M, Okamura H, Sasano H . 3\u03b2-hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma. Mol Cell Endocrinol 2015; 408: 205\u2013212.","journal-title":"Mol Cell Endocrinol"},{"key":"BFhr201691_CR6","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/hr.2013.124","volume":"37","author":"T Hattori","year":"2014","unstructured":"Hattori T, Murase T, Sugiura Y, Nagasawa K, Takahashi K, Ohtake M, Ohtake M, Miyachi M, Murohara T, Nagata K . Effects of salt status and blockade of mineralocorticoid receptors on aldosterone-induced cardiac injury. Hypertens Res 2014; 37: 125\u2013133.","journal-title":"Hypertens Res"},{"key":"BFhr201691_CR7","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1126\/science.1202887","volume":"331","author":"JW Funder","year":"2011","unstructured":"Funder JW . The genetics of primary aldosteronism. Science 2011; 331: 685\u2013686.","journal-title":"Science"},{"key":"BFhr201691_CR8","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/S0092-8674(00)80566-8","volume":"96","author":"JC Dunlap","year":"1999","unstructured":"Dunlap JC . Molecuar bases for circadian clocks. Cell 1999; 96: 271\u2013290.","journal-title":"Cell"},{"key":"BFhr201691_CR9","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1126\/science.1059542","volume":"292","author":"K Yagita","year":"2001","unstructured":"Yagita K, Tamanini F, van der Horst G, Okamura H . Molecular mechanisms of the biological clock in cultured fibroblasts. Science 2001; 292: 278\u2013281.","journal-title":"Science"},{"key":"BFhr201691_CR10","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/S0092-8674(02)01225-4","volume":"111","author":"U Schibler","year":"2002","unstructured":"Schibler U, Sassone-Corsi P . A web of circadian pacemakers. Cell 2002; 111: 919\u2013922.","journal-title":"Cell"},{"key":"BFhr201691_CR11","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1177\/0748730404269169","volume":"19","author":"H Okamura","year":"2004","unstructured":"Okamura H . Clock genes and cell clocks: roles, actions and mysteries. J Biol Rhythm 2004; 19: 388\u2013399.","journal-title":"J Biol Rhythm"},{"key":"BFhr201691_CR12","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0092-8674(02)00803-6","volume":"110","author":"MP Pando","year":"2002","unstructured":"Pando MP, Morse D, Cermakian N, Sassone-Corsi P . Phenotypic rescue of a peripheral clock genetic defect via SCN hierarchical dominance. Cell 2002; 110: 107\u2013117.","journal-title":"Cell"},{"key":"BFhr201691_CR13","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1101\/sqb.2007.72.033","volume":"72","author":"H Okamura","year":"2007","unstructured":"Okamura H . Suprachiasmatic nucleus clock time in the mammalian circadian system. Cold Spring Harb Symp Quant Biol 2007; 72: 551\u2013556.","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"BFhr201691_CR14","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0092-8674(02)00722-5","volume":"109","author":"S Panda","year":"2002","unstructured":"Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, Schultz PG, Kay SA, Takahashi JS, Hogenesch JB . Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 2002; 109: 307\u2013320.","journal-title":"Cell"},{"key":"BFhr201691_CR15","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1128\/MCB.11.1.558","volume":"11","author":"JJ Loros","year":"1991","unstructured":"Loros JJ, Dunlap JC . Neurospora crassa clock-controlled genes are regulated at the level of transcription. Mol Cell Biol 1991; 11: 558\u2013563.","journal-title":"Mol Cell Biol"},{"key":"BFhr201691_CR16","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.celrep.2012.03.001","volume":"1","author":"JM Fustin","year":"2012","unstructured":"Fustin JM, Doi M, Yamada H, Komatsu R, Shimba S, Okamura H . Rhythmic nucleotide synthesis in the liver: temporal segregation of metabolites. Cell Rep 2012; 1: 341\u2013349.","journal-title":"Cell Rep"},{"key":"BFhr201691_CR17","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1126\/science.1150179","volume":"318","author":"L Yin","year":"2007","unstructured":"Yin L, Wu N, Curtin JC, Qatanani M, Szwergold NR, Reid RA, Waitt GM, Parks DJ, Pearce KH, Wisely GB, Lazar MA . Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Science 2007; 318: 1786\u20131789.","journal-title":"Science"},{"key":"BFhr201691_CR18","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1126\/science.1086271","volume":"302","author":"T Matsuo","year":"2003","unstructured":"Matsuo T, Yamaguchi S, Mitsui S, Emi A, Shimoda F, Okamura H . Control mechanism of the circadian clock for timing of cell division in vivo. Science 2003; 302: 255\u2013259.","journal-title":"Science"},{"key":"BFhr201691_CR19","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0092-8674(00)80959-9","volume":"96","author":"X Jin","year":"1999","unstructured":"Jin X, Shearman LP, Weaver DR, Zylka MJ, de Vries GJ, Reppert SM . A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell 1999; 96: 57\u201368.","journal-title":"Cell"},{"key":"BFhr201691_CR20","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/19323","volume":"398","author":"GT van der Horst","year":"1999","unstructured":"van der Horst GT, Muijtjens M, Kobayashi K, Takano R, Kanno S, Takao M, de Wit J, Verkerk A, Eker AP, van Leenen D, Buijs R, Bootsma D, Hoeijmakers JH, Yasui A . Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature 1999; 398: 627\u2013630.","journal-title":"Nature"},{"key":"BFhr201691_CR21","doi-asserted-by":"publisher","first-page":"2531","DOI":"10.1126\/science.286.5449.2531","volume":"286","author":"H Okamura","year":"1999","unstructured":"Okamura H, Miyake S, Sumi Y, Yamaguchi S, Yasui A, Muijtjens M, Hoeijmakers JH, van der Horst GT . Photic induction of mPer1 and mPer2 in cry-deficient mice lacking a biological clock. Science 1999; 286: 2531\u20132534.","journal-title":"Science"},{"key":"BFhr201691_CR22","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1126\/science.1059542","volume":"292","author":"K Yagita","year":"2001","unstructured":"Yagita K, Tamanini F, van Der Horst GT, Okamura H . Molecular mechanisms of the biological clock in cultured fibroblasts. Science 2001; 292: 278\u2013281.","journal-title":"Science"},{"key":"BFhr201691_CR23","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.mce.2013.09.014","volume":"382","author":"K Yamamura","year":"2014","unstructured":"Yamamura K, Doi M, Hayashi H, Ota T, Murai I, Hotta Y, Komatsu R, Okamura H . Immunolocalization of murine type IV 3\u03b2-hydroxysteroid dehydrogenase in the adrenal gland, testis, skin, and placenta. Mol Cell Endocrinol 2014; 382: 131\u2013138.","journal-title":"Mol Cell Endocrinol"},{"key":"BFhr201691_CR24","doi-asserted-by":"publisher","first-page":"3880","DOI":"10.1128\/MCB.00852-14","volume":"34","author":"T Ota","year":"2014","unstructured":"Ota T, Doi M, Yamazaki F, Yarimizu D, Okada K, Murai I, Hayashi H, Kunisue S, Nakagawa Y, Okamura H . Angiotensin II triggers expression of the adrenal gland zona glomerulosa-specific 3\u03b2-hydroxysteroid dehydrogenase isoenzyme through de novo protein synthesis of the orphan nuclear receptors NGFIB and NURR1. Mol Cell Biol 2014; 34: 3880\u20133940.","journal-title":"Mol Cell Biol"},{"key":"BFhr201691_CR25","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1507\/endocrj.EJ15-0211","volume":"62","author":"D Yarimizu","year":"2015","unstructured":"Yarimizu D, Doi M, Ota T, Okamura H . Stimulus-selective induction of the orphan nuclear receptor NGFIB underlies different influences of angiotensin II and potassium on the human adrenal zona glomerulosa 3\u03b2-HSD isoform in H295R cells. Endocr J 2015; 62: 765\u2013776.","journal-title":"Endocr J"},{"key":"BFhr201691_CR26","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1507\/endocrj.41.471","volume":"41","author":"H Sasano","year":"1994","unstructured":"Sasano H . Localization of steroidogenic enzymes in adrenal cortex and its disorders. Endocr J 1994; 41: 471\u2013482.","journal-title":"Endocr J"},{"key":"BFhr201691_CR27","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1507\/endocrj.EJ12-0270","volume":"60","author":"I Sakuma","year":"2013","unstructured":"Sakuma I, Suematsu S, Matsuzawa Y, Saito J, Omura M, Maekawa T, Nakamura Y, Sasano H, Nishikawa T . Characterization of steroidogenic enzyme expression in aldosterone-producing adenoma: a comparison with various human adrenal tumors. Endocr J 2013; 60: 329\u2013336.","journal-title":"Endocr J"},{"key":"BFhr201691_CR28","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s11906-011-0181-3","volume":"13","author":"H Okamura","year":"2011","unstructured":"Okamura H, Doi M, Yamaguchi Y, Fustin JM . Hypertension due to loss of clock: novel insight from the molecular analysis of Cry1\/Cry2-deleted mice. Curr Hypertens Rep 2011; 13: 103\u2013108.","journal-title":"Curr Hypertens Rep"},{"key":"BFhr201691_CR29","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/hr.2013.143","volume":"37","author":"DA Nugrahaningsih","year":"2014","unstructured":"Nugrahaningsih DA, Emoto N, Vignon-Zellweger N, Purnomo E, Yagi K, Nakayama K, Doi M, Okamura H, Hirata K . Chronic hyperaldosteronism in cryptochrome-null mice induces high-salt- and blood pressure-independent kidney damage in mice. Hypertens Res 2014; 37: 202\u2013309.","journal-title":"Hypertens Res"},{"key":"BFhr201691_CR30","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1126\/science.1198785","volume":"331","author":"M Choi","year":"2011","unstructured":"Choi M, Scholl UI, Yue P, Bj\u00f6rklund P, Zhao B, Nelson-Williams C, Ji W, Cho Y, Patel A, Men CJ, Lolis E, Wisgerhof MV, Geller DS, Mane S, Hellman P, Westin G, \u00c5kerstr\u00f6m G, Wang W, Carling T, Carling T . K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science 2011; 331: 768\u2013772.","journal-title":"Science"},{"key":"BFhr201691_CR31","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1038\/ng.2716","volume":"45","author":"EA Azizan","year":"2013","unstructured":"Azizan EA, Poulsen H, Tuluc P, Zhou J, Clausen MV, Lieb A, Maniero C, Garg S, Bochukova EG, Zhao W, Shaikh LH, Brighton CA, Teo AE, Davenport AP, Dekkers T, Tops B, K\u00fcsters B, Ceral J, Yeo GS, Neogi SG, McFarlane I, Rosenfeld N, Marass F, Hadfield J, Margas W, Chaggar K, Solar M, Deinum J, Dolphin AC, Farooqi IS, Striessnig J, Nissen P, Brown MJ . Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat Genet 2013; 45: 1055\u20131060.","journal-title":"Nat Genet"},{"key":"BFhr201691_CR32","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1056\/NEJMoa1504869","volume":"373","author":"AE Teo","year":"2015","unstructured":"Teo AE, Garg S, Shaikh LH, Zhou J, Karet Frankl FE, Gurnell M, Happerfield L, Marker A, Bienz M, Azizan EA, Brown MJ . Pregnancy, primary aldosteronism, and adrenal CTNNB1 mutations. N Engl J Med 2015; 373: 1429\u20131436.","journal-title":"N Engl J Med"},{"key":"BFhr201691_CR33","doi-asserted-by":"publisher","first-page":"e1001141","DOI":"10.1371\/journal.pmed.1001141","volume":"8","author":"A Pan","year":"2011","unstructured":"Pan A, Schernhammer ES, Sun Q, Hu FB . Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in women. Plos Med 2011; 8: e1001141.","journal-title":"Plos Med"},{"key":"BFhr201691_CR34","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s10552-006-0012-z","volume":"17","author":"M Moser","year":"2006","unstructured":"Moser M, Moser M, Schaumberger K, Schernhammer E, Stevens RG . Cancer and rhythm. Cancer Causes Cont 2006; 17: 483\u2013487.","journal-title":"Cancer Causes Cont"},{"key":"BFhr201691_CR35","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1248\/bpb.b12-00364","volume":"35","author":"M Doi","year":"2012","unstructured":"Doi M . Circadian clock-deficient mice as a tool for exploring disease etiology. Biol Pharm Bull 2012; 35: 1385\u20131391.","journal-title":"Biol Pharm Bull"},{"key":"BFhr201691_CR36","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1146\/annurev-neuro-060909-153128","volume":"35","author":"JA Mohawk","year":"2012","unstructured":"Mohawk JA, Green CB, Takahashi JS . Central and peripheral circadian clocks in mammals. Annu Rev Neurosci 2012; 35: 445\u2013462.","journal-title":"Annu Rev Neurosci"},{"key":"BFhr201691_CR37","doi-asserted-by":"publisher","first-page":"aac4250","DOI":"10.1126\/science.aac4250","volume":"350","author":"M Perelis","year":"2015","unstructured":"Perelis M, Marcheva B, Ramsey KM, Schipma MJ, Hutchison AL, Taguchi A, Peek CB, Hong H, Huang W, Omura C, Allred AL, Bradfield CA, Dinner AR, Barish GD, Bass J . Pancreatic \u03b2 cell enhancers regulate rhythmic transcription of genes controlling insulin secretion. Science 2015; 350: aac4250.","journal-title":"Science"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/hr201691.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr201691","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/hr201691.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:17:18Z","timestamp":1684430238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/hr201691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,21]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["BFhr201691"],"URL":"https:\/\/doi.org\/10.1038\/hr.2016.91","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,21]]},"assertion":[{"value":"20 May 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}