{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:49:33Z","timestamp":1788245373931,"version":"build-2803163510"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T00:00:00Z","timestamp":1470873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T00:00:00Z","timestamp":1470873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1038\/hr.2016.97","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T07:15:00Z","timestamp":1470899700000},"page":"67-72","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Mesenchymal-to-epithelial transition in the placental tissues of patients with preeclampsia"],"prefix":"10.1038","volume":"40","author":[{"given":"Lili","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dunjin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,11]]},"reference":[{"key":"BFhr201697_CR1","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","volume":"376","author":"EA Steegers","year":"2010","unstructured":"Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R . Pre-eclampsia. Lancet 2010; 376: 631\u2013644.","journal-title":"Lancet"},{"key":"BFhr201697_CR2","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1161\/HYPERTENSIONAHA.107.107607","volume":"51","author":"B Huppertz","year":"2008","unstructured":"Huppertz B . Placental origins of preeclampsia: challenging the current hypothesis. Hypertension 2008; 51: 970\u2013975.","journal-title":"Hypertension"},{"key":"BFhr201697_CR3","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/nrc822","volume":"2","author":"JP Thiery","year":"2002","unstructured":"Thiery JP . Epithelial\u2013mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2: 442\u2013454.","journal-title":"Nat Rev Cancer"},{"key":"BFhr201697_CR4","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/nrm3758","volume":"15","author":"S Lamouille","year":"2014","unstructured":"Lamouille S, Xu J, Derynck R . Molecular mechanisms of epithelial\u2013mesenchymal transition. Nat Rev Mol Cell Biol 2014; 15: 178\u2013196.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFhr201697_CR5","first-page":"75","volume":"1796","author":"A Voulgari","year":"2009","unstructured":"Voulgari A, Pintzas A . Epithelial\u2013mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. Biochim Biophys Acta 2009; 1796: 75\u201390.","journal-title":"Biochim Biophys Acta"},{"key":"BFhr201697_CR6","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.placenta.2010.06.017","volume":"31","author":"MI Kokkinos","year":"2010","unstructured":"Kokkinos MI, Murthi P, Wafai R, Thompson EW, Newgreen DF . Cadherins in the human placenta\u2014epithelial\u2013mesenchymal transition (EMT) and placental development. Placenta 2010; 31: 747\u2013755.","journal-title":"Placenta"},{"key":"BFhr201697_CR7","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/00004347-200301000-00013","volume":"22","author":"HW Li","year":"2003","unstructured":"Li HW, Cheung AN, Tsao SW, Cheung AL, O WS . Expression of e-cadherin and beta-catenin in trophoblastic tissue in normal and pathological pregnancies. Int J Gynecol Pathol 2003; 22: 63\u201370.","journal-title":"Int J Gynecol Pathol"},{"key":"BFhr201697_CR8","first-page":"1274","volume":"5","author":"U Cavallaro","year":"2004","unstructured":"Cavallaro U . N-cadherin as an invasion promoter: a novel target for antitumor therapy? Curr Opin Investig Drugs 2004; 5: 1274\u20131278.","journal-title":"Curr Opin Investig Drugs"},{"key":"BFhr201697_CR9","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1172\/JCI38019","volume":"119","author":"H Acloque","year":"2009","unstructured":"Acloque H, Adams MS, Fishwick K, Bronner-Fraser M, Nieto MA . Epithelial\u2013mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest 2009; 119: 1438\u20131449.","journal-title":"J Clin Invest"},{"key":"BFhr201697_CR10","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.1158\/0008-5472.CAN-05-3401","volume":"66","author":"NR Alexander","year":"2006","unstructured":"Alexander NR, Tran NL, Rekapally H, Summers CE, Glackin C, Heimark RL . N-cadherin gene expression in prostate carcinoma is modulated by integrin-dependent nuclear translocation of Twist1. Cancer Res 2006; 66: 3365\u20133369.","journal-title":"Cancer Res"},{"key":"BFhr201697_CR11","doi-asserted-by":"publisher","first-page":"E2216","DOI":"10.1210\/jc.2014-2118","volume":"99","author":"Y Li","year":"2014","unstructured":"Li Y, Klausen C, Cheng JC, Zhu H, Leung PC . Activin A, B and AB increase human trophoblast cell invasion by up-regulating N-cadherin. J Clin Endocrinol Metab 2014; 99: E2216\u2013E2225.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFhr201697_CR12","doi-asserted-by":"publisher","first-page":"E19","DOI":"10.1210\/jc.2014-1897","volume":"100","author":"B Peng","year":"2015","unstructured":"Peng B, Zhu H, Leung PC . Gonadotropin-releasing hormone regulates human trophoblastic cell invasion via TWIST-induced N-cadherin expression. J Clin Endocrinol Metab 2015; 100: E19\u2013E29.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFhr201697_CR13","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1159\/000147847","volume":"156","author":"L Vicovac","year":"1996","unstructured":"Vicovac L, Aplin JD . Epithelial\u2013mesenchymal transition during trophoblast differentiation. Acta Anat (Basel) 1996; 156: 202\u2013216.","journal-title":"Acta Anat (Basel)"},{"key":"BFhr201697_CR14","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1093\/molehr\/6.10.943","volume":"6","author":"C Floridon","year":"2000","unstructured":"Floridon C, Nielsen O, Holund B, Sunde L, Westergaard JG, Thomsen SG, Teisner B . Localization of E-cadherin in villous, extravillous and vascular trophoblasts during intrauterine, ectopic and molar pregnancy. Mol Hum Reprod 2000; 6: 943\u2013950.","journal-title":"Mol Hum Reprod"},{"key":"BFhr201697_CR15","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1242\/dev.01907","volume":"132","author":"A Barrallo-Gimeno","year":"2005","unstructured":"Barrallo-Gimeno A, Nieto MA . The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 2005; 132: 3151\u20133161.","journal-title":"Development"},{"key":"BFhr201697_CR16","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1242\/jcs.00224","volume":"116","author":"V Bolos","year":"2003","unstructured":"Bolos V, Peinado H, Perez-Moreno MA, Fraga MF, Esteller M, Cano A . The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci 2003; 116: 499\u2013511.","journal-title":"J Cell Sci"},{"key":"BFhr201697_CR17","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.ygyno.2004.12.043","volume":"97","author":"NK Kurrey","year":"2005","unstructured":"Kurrey NK, Amit K, Bapat A . Snail and Slug are major determinants of ovarian cancer invasiveness at the transcription level. Gynecol Oncol 2005; 97: 155\u2013165.","journal-title":"Gynecol Oncol"},{"key":"BFhr201697_CR18","doi-asserted-by":"publisher","first-page":"e43119","DOI":"10.1371\/journal.pone.0043119","volume":"7","author":"X Xu","year":"2012","unstructured":"Xu X, Zhou Y, Xie C, Wei SM, Gan H, He S, Wang F, Xu L, Lu J, Dai W, He L, Chen P, Wang X, Guo C . Genome-wide screening reveals an EMT molecular network mediated by Sonic hedgehog-Gli1 signaling in pancreatic cancer cells. PLoS ONE 2012; 7: e43119.","journal-title":"PLoS ONE"},{"key":"BFhr201697_CR19","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1016\/j.bbagen.2015.04.005","volume":"1850","author":"C Tang","year":"2015","unstructured":"Tang C, Mei L, Pan L, Xiong W, Zhu H, Ruan H, Zou C, Tang L, Iguchi T, Wu X . Hedgehog signaling through GLI1 and GLI2 is required for epithelial\u2013mesenchymal transition in human trophoblasts. Biochim Biophys Acta 2015; 1850: 1438\u20131448.","journal-title":"Biochim Biophys Acta"},{"key":"BFhr201697_CR20","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0303-7207(01)00687-6","volume":"187","author":"D Goldman-Wohl","year":"2002","unstructured":"Goldman-Wohl D, Yagel S . Regulation of trophoblast invasion: from normal implantation to pre-eclampsia. Mol Cell Endocrinol 2002; 187: 233\u2013238.","journal-title":"Mol Cell Endocrinol"},{"key":"BFhr201697_CR21","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1161\/HYPERTENSIONAHA.113.01892","volume":"62","author":"F Lyall","year":"2013","unstructured":"Lyall F, Robson SC, Bulmer JN . Spiral artery remodeling and trophoblast invasion in preeclampsia and fetal growth restriction: relationship to clinical outcome. Hypertension 2013; 62: 1046\u20131054.","journal-title":"Hypertension"},{"key":"BFhr201697_CR22","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/hr.2014.27","volume":"37","author":"L Kulmala","year":"2014","unstructured":"Kulmala L, Phupong V . Combination of plasma-soluble fms-like tyrosine kinase 1 and uterine artery Doppler for the prediction of preeclampsia in cases of elderly gravida. Hypertens Res 2014; 37: 538\u2013542.","journal-title":"Hypertens Res"},{"key":"BFhr201697_CR23","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/hr.2014.71","volume":"37","author":"AS Sahay","year":"2014","unstructured":"Sahay AS, Patil VV, Sundrani DP, Joshi AA, Wagh GN, Gupte SA, Joshi SR . A longitudinal study of circulating angiogenic and antiangiogenic factors and AT1-AA levels in preeclampsia. Hypertens Res 2014; 37: 753\u2013758.","journal-title":"Hypertens Res"},{"key":"BFhr201697_CR24","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1034\/j.1600-0412.2003.00220.x","volume":"82","author":"T Naicker","year":"2003","unstructured":"Naicker T, Khedun SM, Moodley J, Pijnenborg R . Quantitative analysis of trophoblast invasion in preeclampsia. Acta Obstet Gynecol Scand 2003; 82: 722\u2013729.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"BFhr201697_CR25","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/ncb2976","volume":"16","author":"A Puisieux","year":"2014","unstructured":"Puisieux A, Brabletz T, Caramel J . Oncogenic roles of EMT-inducing transcription factors. Nat Cell Biol 2014; 16: 488\u2013494.","journal-title":"Nat Cell Biol"},{"key":"BFhr201697_CR26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s10555-008-9169-0","volume":"28","author":"M Yilmaz","year":"2009","unstructured":"Yilmaz M, Christofori G . EMT, the cytoskeleton, and cancer cell invasion. Cancer Metast Rev 2009; 28: 15\u201333.","journal-title":"Cancer Metast Rev"},{"key":"BFhr201697_CR27","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.placenta.2015.04.001","volume":"36","author":"CM Duzyj","year":"2015","unstructured":"Duzyj CM, Buhimschi IA, Motawea H, Laky CA, Cozzini G, Zhao G, Funai EF, Buhimschi CS . The invasive phenotype of placenta accreta extravillous trophoblasts associates with loss of E-cadherin. Placenta 2015; 36: 645\u2013651.","journal-title":"Placenta"},{"key":"BFhr201697_CR28","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1210\/en.2011-1488","volume":"153","author":"YH Ng","year":"2012","unstructured":"Ng YH, Zhu H, Leung PC . Twist modulates human trophoblastic cell invasion via regulation of N-cadherin. Endocrinology 2012; 153: 925\u2013936.","journal-title":"Endocrinology"},{"key":"BFhr201697_CR29","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.placenta.2014.04.010","volume":"35","author":"XL Li","year":"2014","unstructured":"Li X L, Dong X, Xue Y, Li CF, Gou WL, Chen Q . Increased expression levels of E-cadherin, cytokeratin 18 and 19 observed in preeclampsia were not correlated with disease severity. Placenta 2014; 35: 625\u2013631.","journal-title":"Placenta"},{"key":"BFhr201697_CR30","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","volume":"139","author":"JP Thiery","year":"2009","unstructured":"Thiery JP, Acloque H, Huang RY, Nieto MA . Epithelial\u2013mesenchymal transitions in development and disease. Cell 2009; 139: 871\u2013890.","journal-title":"Cell"},{"key":"BFhr201697_CR31","first-page":"1613","volume":"62","author":"KM Hajra","year":"2002","unstructured":"Hajra KM, Chen DY, Fearon ER . The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res 2002; 62: 1613\u20131618.","journal-title":"Cancer Res"},{"key":"BFhr201697_CR32","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/dc.21746","volume":"41","author":"XN Li","year":"2013","unstructured":"Li X N, Fang CQ, Wang YL, Wang XR, Wang EH, Li JH . Slug regulates E-cadherin expression in metastatic adenocarcinoma cells isolated from pleural fluid. Diagn Cytopathol 2013; 41: 9\u201314.","journal-title":"Diagn Cytopathol"},{"key":"BFhr201697_CR33","doi-asserted-by":"publisher","first-page":"25431","DOI":"10.1074\/jbc.M113.527267","volume":"289","author":"A Adhikary","year":"2014","unstructured":"Adhikary A, Chakraborty S, Mazumdar M, Ghosh S, Mukherjee S, Manna A, Mohanty S, Nakka KK, Joshi S, De A, Chattopadhyay S, Sa G, Das T . Inhibition of epithelial to mesenchymal transition by E-cadherin up-regulation via repression of slug transcription and inhibition of E-cadherin degradation: dual role of scaffold\/matrix attachment region-binding protein 1 (SMAR1) in breast cancer cells. J Biol Chem 2014; 289: 25431\u201325444.","journal-title":"J Biol Chem"},{"key":"BFhr201697_CR34","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1477-7827-10-15","volume":"10","author":"L Fedorova","year":"2012","unstructured":"Fedorova L, Gatto-Weis C, Smaili S, Khurshid N, Shapiro J I, Malhotra D, Horrigan T . Down-regulation of the transcription factor snail in the placentas of patients with preeclampsia and in a rat model of preeclampsia. Reprod Biol Endocrinol 2012; 10: 15.","journal-title":"Reprod Biol Endocrinol"},{"key":"BFhr201697_CR35","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/sj.onc.1209054","volume":"25","author":"S Kuphal","year":"2006","unstructured":"Kuphal S, Bosserhoff AK . Influence of the cytoplasmic domain of E-cadherin on endogenous N-cadherin expression in malignant melanoma. Oncogene 2006; 25: 248\u2013259.","journal-title":"Oncogene"},{"key":"BFhr201697_CR36","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1002\/jcp.24165","volume":"228","author":"JP Palma-Nicolas","year":"2013","unstructured":"Palma-Nicolas JP, Lopez-Colome AM . Thrombin induces slug-mediated E-cadherin transcriptional repression and the parallel up-regulation of N-cadherin by a transcription-independent mechanism in RPE cells. J Cell Physiol 2013; 228: 581\u2013589.","journal-title":"J Cell Physiol"},{"key":"BFhr201697_CR37","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/1756-9966-33-34","volume":"33","author":"D Yue","year":"2014","unstructured":"Yue D, Li H, Che J, Zhang Y, Tseng HH, Jin JQ, Luh TM, Giroux-Leprieur E, Mo M, Zheng Q, Shi H, Zhang H, Hao X, Wang C, Jablons DM, He B . Hedgehog\/Gli promotes epithelial\u2013mesenchymal transition in lung squamous cell carcinomas. J Exp Clin Cancer Res 2014; 33: 34.","journal-title":"J Exp Clin Cancer Res"},{"key":"BFhr201697_CR38","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1681\/ASN.2011060614","volume":"23","author":"H Ding","year":"2012","unstructured":"Ding H, Zhou D, Hao S, Zhou L, He W, Nie J, Hou FF, Liu Y . Sonic hedgehog signaling mediates epithelial\u2013mesenchymal communication and promotes renal fibrosis. J Am Soc Nephrol 2012; 23: 801\u2013813.","journal-title":"J Am Soc Nephrol"},{"key":"BFhr201697_CR39","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/hr.2015.7","volume":"38","author":"MK Leow","year":"2015","unstructured":"Leow M K . Environmental origins of hypertension: phylogeny, ontogeny and epigenetics. Hypertens Res 2015; 38: 299\u2013307.","journal-title":"Hypertens Res"},{"key":"BFhr201697_CR40","doi-asserted-by":"publisher","first-page":"8121","DOI":"10.3892\/mmr.2015.4452","volume":"12","author":"F Yu","year":"2015","unstructured":"Yu F, Zheng Y, Hong W, Chen B, Dong P, Zheng J . MicroRNA200a suppresses epithelial-to-mesenchymal transition in rat hepatic stellate cells via GLI family zinc finger 2. Mol Med Rep 2015; 12: 8121\u20138128.","journal-title":"Mol Med Rep"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/hr201697.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/hr201697","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/hr201697.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T02:02:21Z","timestamp":1641002541000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/hr201697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,11]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["BFhr201697"],"URL":"https:\/\/doi.org\/10.1038\/hr.2016.97","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,11]]},"assertion":[{"value":"20 December 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}