{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:09:41Z","timestamp":1790338181453,"version":"4.1.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hypertens Res"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1038\/hr.2017.72","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T10:46:01Z","timestamp":1504781161000},"page":"966-975","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["EPA:DHA 6:1 prevents angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase- and COX-derived oxidative stress"],"prefix":"10.1038","volume":"40","author":[{"given":"Zahid Rasul","family":"Niazi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazielle C","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais Porto","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio J","family":"Le\u00f3n-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Kassem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdur","family":"Mirajkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azhar","family":"Alvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malak","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faraj","family":"Zgheel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie B","family":"Schini-Kerth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Auger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,7]]},"reference":[{"key":"BFhr201772_CR1","first-page":"e38","volume":"133","author":"D Mozaffarian","year":"2016","unstructured":"Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, Das SR, de Ferranti S, Despres JP, Fullerton HJ, Howard VJ, Huffman MD, Isasi CR, Jimenez MC, Judd SE, Kissela BM, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Magid DJ, McGuire DK, Mohler ER 3rd, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Rosamond W, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Woo D, Yeh RW, Turner MB American Heart Association Statistics C, Stroke Statistics S. Heart Disease and Stroke Statistics-2016 Update: a report from the American Heart Association. Circulation 2016; 133: e38\u2013e360.","journal-title":"Circulation"},{"key":"BFhr201772_CR2","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/j.1748-1716.2009.01964.x","volume":"196","author":"PM Vanhoutte","year":"2009","unstructured":"Vanhoutte PM, Shimokawa H, Tang EH, Feletou M . Endothelial dysfunction and vascular disease. Acta Physiol (Oxford, Engl) 2009; 196: 193\u2013222.","journal-title":"Acta Physiol (Oxford, Engl)"},{"key":"BFhr201772_CR3","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/apha.12646","volume":"219","author":"PM Vanhoutte","year":"2017","unstructured":"Vanhoutte PM, Shimokawa H, Feletou M, Tang EH . Endothelial dysfunction and vascular disease-a 30th anniversary update. Acta Physiol (Oxford, Engl) 2017; 219: 22\u201396.","journal-title":"Acta Physiol (Oxford, Engl)"},{"key":"BFhr201772_CR4","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.bbrc.2012.02.031","volume":"419","author":"S Dal-Ros","year":"2012","unstructured":"Dal-Ros S, Bronner C, Auger C, Schini-Kerth VB . Red wine polyphenols improve an established aging-related endothelial dysfunction in the mesenteric artery of middle-aged rats: role of oxidative stress. Biochem Biophys Res Commun 2012; 419: 381\u2013387.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFhr201772_CR5","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1124\/jpet.108.145326","volume":"328","author":"S Dal-Ros","year":"2009","unstructured":"Dal-Ros S, Bronner C, Schott C, Kane MO, Chataigneau M, Schini-Kerth VB, Chataigneau T . Angiotensin II-induced hypertension is associated with a selective inhibition of endothelium-derived hyperpolarizing factor-mediated responses in the rat mesenteric artery. J Pharmacol Exp Ther 2009; 328: 478\u2013486.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFhr201772_CR6","doi-asserted-by":"publisher","first-page":"e32039","DOI":"10.1371\/journal.pone.0032039","volume":"7","author":"N Idris Khodja","year":"2012","unstructured":"Idris Khodja N, Chataigneau T, Auger C, Schini-Kerth VB . Grape-derived polyphenols improve aging-related endothelial dysfunction in rat mesenteric artery: role of oxidative stress and the angiotensin system. PLoS ONE 2012; 7: e32039.","journal-title":"PLoS ONE"},{"key":"BFhr201772_CR7","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s00424-009-0759-7","volume":"459","author":"MO Kane","year":"2010","unstructured":"Kane MO, Etienne-Selloum N, Madeira SV, Sarr M, Walter A, Dal-Ros S, Schott C, Chataigneau T, Schini-Kerth VB . Endothelium-derived contracting factors mediate the Ang II-induced endothelial dysfunction in the rat aorta: preventive effect of red wine polyphenols. Pflugers Arch 2010; 459: 671\u2013679.","journal-title":"Pflugers Arch"},{"key":"BFhr201772_CR8","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s00210-011-0643-9","volume":"383","author":"JO Lee","year":"2011","unstructured":"Lee JO, Oak MH, Jung SH, Park DH, Auger C, Kim KR, Lee SW, Schini-Kerth VB . An ethanolic extract of Lindera obtusiloba stems causes NO-mediated endothelium-dependent relaxations in rat aortic rings and prevents angiotensin II-induced hypertension and endothelial dysfunction in rats. Naunyn-Schmiedeberg Arch Pharmacol 2011; 383: 635\u2013645.","journal-title":"Naunyn-Schmiedeberg Arch Pharmacol"},{"key":"BFhr201772_CR9","doi-asserted-by":"publisher","first-page":"e65227","DOI":"10.1371\/journal.pone.0065227","volume":"8","author":"JO Lee","year":"2013","unstructured":"Lee JO, Auger C, Park DH, Kang M, Oak MH, Kim KR, Schini-Kerth VB . An ethanolic extract of Lindera obtusiloba stems, YJP-14, improves endothelial dysfunction, metabolic parameters and physical performance in diabetic db\/db mice. PLoS ONE 2013; 8: e65227.","journal-title":"PLoS ONE"},{"key":"BFhr201772_CR10","doi-asserted-by":"publisher","first-page":"C82","DOI":"10.1152\/ajpcell.00287.2006","volume":"292","author":"PK Mehta","year":"2007","unstructured":"Mehta PK, Griendling KK . Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol 2007; 292: C82\u2013C97.","journal-title":"Am J Physiol Cell Physiol"},{"key":"BFhr201772_CR11","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3317\/jraas.2003.014","volume":"4","author":"DG Harrison","year":"2003","unstructured":"Harrison DG, Cai H, Landmesser U, Griendling KK . Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease. J Renin Angiotensin Aldosterone Syst 2003; 4: 51\u201361.","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"BFhr201772_CR12","doi-asserted-by":"publisher","first-page":"3022","DOI":"10.2174\/1381612811319170008","volume":"19","author":"C Sunggip","year":"2013","unstructured":"Sunggip C, Kitajima N, Nishida M . Redox control of cardiovascular homeostasis by angiotensin II. Curr Pharm Design 2013; 19: 3022\u20133032.","journal-title":"Curr Pharm Design"},{"key":"BFhr201772_CR13","doi-asserted-by":"publisher","first-page":"28668","DOI":"10.1074\/jbc.M113.470971","volume":"288","author":"DY Lee","year":"2013","unstructured":"Lee DY, Wauquier F, Eid AA, Roman LJ, Ghosh-Choudhury G, Khazim K, Block K, Gorin Y . Nox4 NADPH oxidase mediates peroxynitrite-dependent uncoupling of endothelial nitric-oxide synthase and fibronectin expression in response to angiotensin II: role of mitochondrial reactive oxygen species. J Biol Chem 2013; 288: 28668\u201328686.","journal-title":"J Biol Chem"},{"key":"BFhr201772_CR14","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1161\/ATVBAHA.113.301514","volume":"33","author":"EJ Behringer","year":"2013","unstructured":"Behringer EJ, Shaw RL, Westcott EB, Socha MJ, Segal SS . Aging impairs electrical conduction along endothelium of resistance arteries through enhanced Ca2+-activated K+ channel activation. Arterioscler Thromb Vasc Biol 2013; 33: 1892\u20131901.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1 Pt 1","key":"BFhr201772_CR15","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1161\/01.HYP.35.1.68","volume":"35","author":"K Ohnaka","year":"2000","unstructured":"Ohnaka K, Numaguchi K, Yamakawa T, Inagami T . Induction of cyclooxygenase-2 by angiotensin II in cultured rat vascular smooth muscle cells. Hypertension 2000; 35 (1 Pt 1): 68\u201375.","journal-title":"Hypertension"},{"key":"BFhr201772_CR16","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1111\/j.1476-5381.2011.01276.x","volume":"164","author":"M Feletou","year":"2011","unstructured":"Feletou M, Huang Y, Vanhoutte PM . Endothelium-mediated control of vascular tone: COX-1 and COX-2 products. Br J Pharmacol 2011; 164: 894\u2013912.","journal-title":"Br J Pharmacol"},{"key":"BFhr201772_CR17","doi-asserted-by":"publisher","first-page":"42","DOI":"10.2174\/157016112798829823","volume":"10","author":"L Ghiadoni","year":"2012","unstructured":"Ghiadoni L, Taddei S, Virdis A . Hypertension and endothelial dysfunction: therapeutic approach. Curr Vasc Phrmacol 2012; 10: 42\u201360.","journal-title":"Curr Vasc Phrmacol"},{"key":"BFhr201772_CR18","doi-asserted-by":"publisher","first-page":"e90217","DOI":"10.1371\/journal.pone.0090217","volume":"9","author":"S Li","year":"2014","unstructured":"Li S, Wu Y, Yu G, Xia Q, Xu Y . Angiotensin II receptor blockers improve peripheral endothelial function: a meta-analysis of randomized controlled trials. PLoS ONE 2014; 9: e90217.","journal-title":"PLoS ONE"},{"issue":"Suppl 2","key":"BFhr201772_CR19","doi-asserted-by":"publisher","first-page":"S201","DOI":"10.1017\/S0007114512001596","volume":"107","author":"J Delgado-Lista","year":"2012","unstructured":"Delgado-Lista J, Perez-Martinez P, Lopez-Miranda J, Perez-Jimenez F . Long chain omega-3 fatty acids and cardiovascular disease: a systematic review. Br J Nutr 2012; 107 (Suppl 2): S201\u2013S213.","journal-title":"Br J Nutr"},{"key":"BFhr201772_CR20","first-page":"399","volume":"14","author":"JJ DiNicolantonio","year":"2014","unstructured":"DiNicolantonio JJ, Niazi AK, McCarty MF, O'Keefe JH, Meier P, Lavie CJ . Omega-3s and cardiovascular health. Ochsner J 2014; 14: 399\u2013412.","journal-title":"Ochsner J"},{"key":"BFhr201772_CR21","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/hr.2015.143","volume":"39","author":"K Iwamatsu","year":"2016","unstructured":"Iwamatsu K, Abe S, Nishida H, Kageyama M, Nasuno T, Sakuma M, Toyoda S, Inoue T . Which has the stronger impact on coronary artery disease, eicosapentaenoic acid or docosahexaenoic acid? Hypertens Res 2016; 39: 272\u2013275.","journal-title":"Hypertens Res"},{"key":"BFhr201772_CR22","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1093\/ajh\/hpu024","volume":"27","author":"PE Miller","year":"2014","unstructured":"Miller PE, Van Elswyk M, Alexander DD . Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and blood pressure: a meta-analysis of randomized controlled trials. Am J Hypertens 2014; 27: 885\u2013896.","journal-title":"Am J Hypertens"},{"key":"BFhr201772_CR23","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1001\/archinte.1993.00410120017003","volume":"153","author":"LJ Appel","year":"1993","unstructured":"Appel LJ, Miller ER 3rd, Seidler AJ, Whelton PK . Does supplementation of diet with 'fish oil' reduce blood pressure? A meta-analysis of controlled clinical trials. Arch Intern Med 1993; 153: 1429\u20131438.","journal-title":"Arch Intern Med"},{"key":"BFhr201772_CR24","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1056\/NEJM198904203201603","volume":"320","author":"HR Knapp","year":"1989","unstructured":"Knapp HR, FitzGerald GA . The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension. N Engl J Med 1989; 320: 1037\u20131043.","journal-title":"N Engl J Med"},{"key":"BFhr201772_CR25","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1097\/00005344-199904000-00017","volume":"33","author":"H Tagawa","year":"1999","unstructured":"Tagawa H, Shimokawa H, Tagawa T, Kuroiwa-Matsumoto M, Hirooka Y, Takeshita A . Long-term treatment with eicosapentaenoic acid augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilatation in patients with coronary artery disease. J Cardiovasc Pharmacol 1999; 33: 633\u2013640.","journal-title":"J Cardiovasc Pharmacol"},{"key":"BFhr201772_CR26","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/0735-1097(93)90357-7","volume":"21","author":"FJ Fleischhauer","year":"1993","unstructured":"Fleischhauer FJ, Yan WD, Fischell TA . Fish oil improves endothelium-dependent coronary vasodilation in heart transplant recipients. J Am Coll Cardiol 1993; 21: 982\u2013989.","journal-title":"J Am Coll Cardiol"},{"key":"BFhr201772_CR27","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0021-9150(02)00307-6","volume":"166","author":"RJ Woodman","year":"2003","unstructured":"Woodman RJ, Mori TA, Burke V, Puddey IB, Barden A, Watts GF, Beilin LJ . Effects of purified eicosapentaenoic acid and docosahexaenoic acid on platelet, fibrinolytic and vascular function in hypertensive type 2 diabetic patients. Atherosclerosis 2003; 166: 85\u201393.","journal-title":"Atherosclerosis"},{"key":"BFhr201772_CR28","doi-asserted-by":"publisher","first-page":"e105102","DOI":"10.1371\/journal.pone.0105102","volume":"9","author":"F Zgheel","year":"2014","unstructured":"Zgheel F, Alhosin M, Rashid S, Burban M, Auger C, Schini-Kerth VB . Redox-sensitive induction of Src\/PI3-kinase\/Akt and MAPKs pathways activate eNOS in response to EPA:DHA 6:1. PLoS ONE 2014; 9: e105102.","journal-title":"PLoS ONE"},{"key":"BFhr201772_CR29","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S0014-5793(00)02351-6","volume":"487","author":"M Omura","year":"2001","unstructured":"Omura M, Kobayashi S, Mizukami Y, Mogami K, Todoroki-Ikeda N, Miyake T, Matsuzaki M . Eicosapentaenoic acid (EPA) induces Ca(2+)-independent activation and translocation of endothelial nitric oxide synthase and endothelium-dependent vasorelaxation. FEBS Lett 2001; 487: 361\u2013366.","journal-title":"FEBS Lett"},{"key":"BFhr201772_CR30","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1177\/1074248408322470","volume":"13","author":"CL Stebbins","year":"2008","unstructured":"Stebbins CL, Stice JP, Hart CM, Mbai FN, Knowlton AA . Effects of dietary decosahexaenoic acid (DHA) on eNOS in human coronary artery endothelial cells. J Cardiovasc Pharmacol Ther 2008; 13: 261\u2013268.","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"BFhr201772_CR31","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1111\/j.1753-4887.2010.00287.x","volume":"68","author":"R Wall","year":"2010","unstructured":"Wall R, Ross RP, Fitzgerald GF, Stanton C . Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids. Nutr Rev 2010; 68: 280\u2013289.","journal-title":"Nutr Rev"},{"key":"BFhr201772_CR32","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0022-3565(25)39423-1","volume":"267","author":"F Grimminger","year":"1993","unstructured":"Grimminger F, Mayer K, Kramer HJ, Stevens J, Walmrath D, Seeger W . Differential vasoconstrictor potencies of free fatty acids in the lung vasculature: 2-versus 3-series prostanoid generation. J Pharmacol Exp Ther 1993; 267: 259\u2013265.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFhr201772_CR33","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1139\/y59-099","volume":"37","author":"EG Bligh","year":"1959","unstructured":"Bligh EG, Dyer WJ . A rapid method of total lipid extraction and purification. Can J Biochem Physil 1959; 37: 911\u2013917.","journal-title":"Can J Biochem Physil"},{"key":"BFhr201772_CR34","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/S0753-3322(02)00253-6","volume":"56","author":"AP Simopoulos","year":"2002","unstructured":"Simopoulos AP . The importance of the ratio of omega-6\/omega-3 essential fatty acids. Biomed Pharmacother 2002; 56: 365\u2013379.","journal-title":"Biomed Pharmacother"},{"key":"BFhr201772_CR35","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/j.jnutbio.2015.07.007","volume":"26","author":"G Dasilva","year":"2015","unstructured":"Dasilva G, Pazos M, Garcia-Egido E, Gallardo JM, Rodriguez I, Cela R, Medina I . Healthy effect of different proportions of marine omega-3 PUFAs EPA and DHA supplementation in Wistar rats: lipidomic biomarkers of oxidative stress and inflammation. J Nutr Biochem 2015; 26: 1385\u20131392.","journal-title":"J Nutr Biochem"},{"key":"BFhr201772_CR36","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1097\/FJC.0b013e318298e460","volume":"62","author":"A Ulu","year":"2013","unstructured":"Ulu A, Harris TR, Morisseau C, Miyabe C, Inoue H, Schuster G, Dong H, Iosif AM, Liu JY, Weiss RH, Chiamvimonvat N, Imig JD, Hammock BD . Anti-inflammatory effects of omega-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II-dependent hypertension. J Cardiovasc Pharmacol 2013; 62: 285\u2013297.","journal-title":"J Cardiovasc Pharmacol"},{"key":"BFhr201772_CR37","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/S0892-0362(02)00219-2","volume":"24","author":"S Kimura","year":"2002","unstructured":"Kimura S, Saito H, Minami M, Togashi H, Nakamura N, Ueno K, Shimamura K, Nemoto M, Parvez H . Docosahexaenoic acid attenuated hypertension and vascular dementia in stroke-prone spontaneously hypertensive rats. Neurotoxicol Teratol 2002; 24: 683\u2013693.","journal-title":"Neurotoxicol Teratol"},{"key":"BFhr201772_CR38","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","volume":"22","author":"S Reagan-Shaw","year":"2008","unstructured":"Reagan-Shaw S, Nihal M, Ahmad N . Dose translation from animal to human studies revisited. FASEB J 2008; 22: 659\u2013661.","journal-title":"FASEB J"},{"key":"BFhr201772_CR39","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/1471-2261-14-70","volume":"14","author":"JE Enns","year":"2014","unstructured":"Enns JE, Yeganeh A, Zarychanski R, Abou-Setta AM, Friesen C, Zahradka P, Taylor CG . The impact of omega-3 polyunsaturated fatty acid supplementation on the incidence of cardiovascular events and complications in peripheral arterial disease: a systematic review and meta-analysis. BMC Cardiovasc Disord 2014; 14: 70.","journal-title":"BMC Cardiovasc Disord"},{"key":"BFhr201772_CR40","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/hr.2014.151","volume":"38","author":"SM Yoo","year":"2015","unstructured":"Yoo SM, Choi SH, Jung MD, Lim SC, Baek SH . Short-term use of telmisartan attenuates oxidation and improves Prdx2 expression more than antioxidant beta-blockers in the cardiovascular systems of spontaneously hypertensive rats. Hypertens Res 2015; 38: 106\u2013115.","journal-title":"Hypertens Res"},{"key":"BFhr201772_CR41","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1172\/JCI118623","volume":"97","author":"S Rajagopalan","year":"1996","unstructured":"Rajagopalan S, Kurz S, Munzel T, Tarpey M, Freeman BA, Griendling KK, Harrison DG . Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH\/NADPH oxidase activation. Contribution to alterations of vasomotor tone. J Clin Invest 1996; 97: 1916\u20131923.","journal-title":"J Clin Invest"},{"key":"BFhr201772_CR42","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/hr.2014.125","volume":"38","author":"MR Al-Magableh","year":"2015","unstructured":"Al-Magableh MR, Kemp-Harper BK, Hart JL . Hydrogen sulfide treatment reduces blood pressure and oxidative stress in angiotensin II-induced hypertensive mice. Hypertens Res 2015; 38: 13\u201320.","journal-title":"Hypertens Res"},{"key":"BFhr201772_CR43","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1007\/s00424-010-0808-2","volume":"459","author":"U F\u00f6rstermann","year":"2010","unstructured":"F\u00f6rstermann U . Nitric oxide and oxidative stress in vascular disease. Pflugers Arch 2010; 459: 923\u2013939.","journal-title":"Pflugers Arch"},{"key":"BFhr201772_CR44","doi-asserted-by":"publisher","first-page":"E58","DOI":"10.1161\/01.RES.0000012569.55432.02","volume":"90","author":"H Mollnau","year":"2002","unstructured":"Mollnau H, Wendt M, Szocs K, Lassegue B, Schulz E, Oelze M, Li H, Bodenschatz M, August M, Kleschyov AL, Tsilimingas N, Walter U, F\u00f6rstermann U, Meinertz T, Griendling K, Munzel T . Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide\/cGMP signaling. Circ Res 2002; 90: E58\u2013E65.","journal-title":"Circ Res"},{"key":"BFhr201772_CR45","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.ejphar.2014.10.042","volume":"746","author":"A Shatanawi","year":"2015","unstructured":"Shatanawi A, Lemtalsi T, Yao L, Patel C, Caldwell RB, Caldwell RW . Angiotensin II limits NO production by upregulating arginase through a p38 MAPK\u2013ATF-2 pathway. Eur J Pharmacol 2015; 746: 106\u2013114.","journal-title":"Eur J Pharmacol"},{"key":"BFhr201772_CR46","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1152\/japplphysiol.91393.2008","volume":"107","author":"JH Kim","year":"2009","unstructured":"Kim JH, Bugaj LJ, Oh YJ, Bivalacqua TJ, Ryoo S, Soucy KG, Santhanam L, Webb A, Camara A, Sikka G, Nyhan D, Shoukas AA, Ilies M, Christianson DW, Champion HC, Berkowitz DE . Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats. J Appl Physiol 2009; 107: 1249\u20131257.","journal-title":"J Appl Physiol"},{"key":"BFhr201772_CR47","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/hr.2016.61","volume":"39","author":"V Mengal","year":"2016","unstructured":"Mengal V, Silva PH, Tiradentes RV, Santuzzi CH, de Almeida SA, Sena GC, Bissoli NS, Abreu GR, Gouvea SA . Aliskiren and l-arginine treatments restore depressed baroreflex sensitivity and decrease oxidative stress in renovascular hypertension rats. Hypertens Res 2016; 39: 769\u2013776.","journal-title":"Hypertens Res"},{"key":"BFhr201772_CR48","doi-asserted-by":"publisher","first-page":"154","DOI":"10.3109\/19390211003785702","volume":"7","author":"J Morre","year":"2010","unstructured":"Morre J, Morre DM, Brightmore R . Omega-3 but not omega-6 unsaturated fatty acids inhibit the cancer-specific ENOX2 of the HeLa cell surface with no effect on the constitutive ENOX1. J Diet Suppl 2010; 7: 154\u2013158.","journal-title":"J Diet Suppl"},{"key":"BFhr201772_CR49","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.phrs.2008.05.002","volume":"57","author":"D Richard","year":"2008","unstructured":"Richard D, Kefi K, Barbe U, Bausero P, Visioli F . Polyunsaturated fatty acids as antioxidants. Pharmacol Res 2008; 57: 451\u2013455.","journal-title":"Pharmacol Res"},{"key":"BFhr201772_CR50","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/B978-0-12-385061-4.00006-4","volume":"60","author":"VB Schini-Kerth","year":"2010","unstructured":"Schini-Kerth VB, Auger C, Etienne-Selloum N, Chataigneau T . Polyphenol-induced endothelium-dependent relaxations role of NO and EDHF. Adv Pharmacol 2010; 60: 133\u2013175.","journal-title":"Adv Pharmacol"},{"key":"BFhr201772_CR51","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1161\/01.HYP.38.2.274","volume":"38","author":"S Taddei","year":"2001","unstructured":"Taddei S, Virdis A, Ghiadoni L, Salvetti G, Bernini G, Magagna A, Salvetti A . Age-related reduction of NO availability and oxidative stress in humans. Hypertension 2001; 38: 274\u2013279.","journal-title":"Hypertension"},{"key":"BFhr201772_CR52","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1124\/jpet.102.037705","volume":"303","author":"ZW Hu","year":"2002","unstructured":"Hu ZW, Kerb R, Shi XY, Wei-Lavery T, Hoffman BB . Angiotensin II increases expression of cyclooxygenase-2: implications for the function of vascular smooth muscle cells. J Pharmacol Exp Ther 2002; 303: 563\u2013573.","journal-title":"J Pharmacol Exp Ther"},{"issue":"6 Pt 2","key":"BFhr201772_CR53","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1161\/01.HYP.21.6.929","volume":"21","author":"S Taddei","year":"1993","unstructured":"Taddei S, Virdis A, Mattei P, Salvetti A . Vasodilation to acetylcholine in primary and secondary forms of human hypertension. Hypertension 1993; 21 (6 Pt 2): 929\u2013933.","journal-title":"Hypertension"},{"key":"BFhr201772_CR54","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.prostaglandins.2009.03.002","volume":"89","author":"H Seki","year":"2009","unstructured":"Seki H, Tani Y, Arita M . Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1. Prostaglandins Other Lipid Mediat 2009; 89: 126\u2013130.","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"BFhr201772_CR55","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3390\/nu2030355","volume":"2","author":"PC Calder","year":"2010","unstructured":"Calder PC . Omega-3 fatty acids and inflammatory processes. Nutrients 2010; 2: 355\u2013374.","journal-title":"Nutrients"},{"key":"BFhr201772_CR56","doi-asserted-by":"publisher","first-page":"14677","DOI":"10.1074\/jbc.M300218200","volume":"278","author":"S Hong","year":"2003","unstructured":"Hong S, Gronert K, Devchand PR, Moussignac RL, Serhan CN . Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem 2003; 278: 14677\u201314687.","journal-title":"J Biol Chem"},{"key":"BFhr201772_CR57","doi-asserted-by":"publisher","first-page":"H1547","DOI":"10.1152\/ajpheart.00452.2014","volume":"307","author":"R Hiram","year":"2014","unstructured":"Hiram R, Rizcallah E, Sirois C, Sirois M, Morin C, Fortin S, Rousseau E . Resolvin D1 reverses reactivity and Ca2+ sensitivity induced by ET-1, TNF-alpha, and IL-6 in the human pulmonary artery. Am J Physiol Heart Circ Physiol 2014; 307: H1547\u2013H1558.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFhr201772_CR58","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1194\/jlr.M200092-JLR200","volume":"44","author":"S Bousserouel","year":"2003","unstructured":"Bousserouel S, Brouillet A, Bereziat G, Raymondjean M, Andreani M . Different effects of n-6 and n-3 polyunsaturated fatty acids on the activation of rat smooth muscle cells by interleukin-1 beta. J Lipid Res 2003; 44: 601\u2013611.","journal-title":"J Lipid Res"},{"key":"BFhr201772_CR59","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1161\/CIRCRESAHA.110.217299","volume":"107","author":"PJ Marvar","year":"2010","unstructured":"Marvar PJ, Thabet SR, Guzik TJ, Lob HE, McCann LA, Weyand C, Gordon FJ, Harrison DG . Central and peripheral mechanisms of T-lymphocyte activation and vascular inflammation produced by angiotensin II\u2013induced hypertension. Circ Res 2010; 107: 263\u2013270.","journal-title":"Circ Res"},{"key":"BFhr201772_CR60","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1161\/HYPERTENSIONAHA.114.04147","volume":"64","author":"DW Trott","year":"2014","unstructured":"Trott DW, Thabet SR, Kirabo A, Saleh MA, Itani H, Norlander AE, Wu J, Goldstein A, Arendshorst WJ, Madhur MS, Chen W, Li CI, Shyr Y, Harrison DG . Oligoclonal CD8+ T cells play a critical role in the development of hypertension. Hypertension 2014; 64: 1108\u20131115.","journal-title":"Hypertension"},{"key":"BFhr201772_CR61","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1017\/S0007114509991346","volume":"103","author":"D Tousoulis","year":"2010","unstructured":"Tousoulis D, Papageorgiou N, Antoniades C, Giolis A, Bouras G, Gounari P, Stefanadi E, Miliou A, Psaltopoulou T, Stefanadis C . Acute effects of different types of oil consumption on endothelial function, oxidative stress status and vascular inflammation in healthy volunteers. Br J Nutr 2010; 103: 43\u201349.","journal-title":"Br J Nutr"}],"container-title":["Hypertension Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/hr201772.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/hr201772","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/hr.2017.72","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/hr201772.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T16:33:40Z","timestamp":1750869220000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/hr201772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,7]]},"references-count":61,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["BFhr201772"],"URL":"https:\/\/doi.org\/10.1038\/hr.2017.72","relation":{},"ISSN":["0916-9636","1348-4214"],"issn-type":[{"value":"0916-9636","type":"print"},{"value":"1348-4214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,7]]},"assertion":[{"value":"17 October 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Drs Abdur Mirajkar and Azhar Alvi are both employees of Pivotal Therapeutics, Inc. All other authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}