{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:28:22Z","timestamp":1777505302563,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1971,2,1]],"date-time":"1971-02-01T00:00:00Z","timestamp":34214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1971,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Copper deficiency depresses phospholipid synthesis by liver mitochondria, but not by liver microsomes. The effect of copper deficiency on mitochondrial phospholipid synthesis is eliminated by adding 1 mM ATP. Phospholipid synthesis by liver mitochondria from normal rats is inhibited by 0\u00b71\u20131 mM CN<jats:sup>\u2212<\/jats:sup> and restored to normal by 1mM ATP. Mitochondria do not synthesise phospholipids significantly under anaerobic conditions with or without added electron transfer systems unless ATP is added. There appears to be a direct causal relationship between the two major biochemical disturbances in copper deficiency. One, the loss of cytochrome oxidase activity, leading to the other, depressed synthesis of phospholipids by liver mitochondria, by interfering with the provision of endogenous ATP to maintain an optimal rate of synthesis under the experimental conditions. Copper deficiency does not deplete acyl\u2010CoA:L\u2010glycerol\u20103\u2010phosphate acyltransferase (E.C.2.3.1.15.) from either microsomes or mitochondria. The activies of palmitoyl\u2010CoA hydrolase (E.C.3.1.2.2.) in liver microsomes or liver mitochondria and of palmitoyl\u2010CoA:carnitine palmitoyl\u2010transferase in liver mitochondria are not affected by copper deficiency.<\/jats:p>","DOI":"10.1038\/icb.1971.3","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T09:28:08Z","timestamp":1196155688000},"page":"21-31","source":"Crossref","is-referenced-by-count":31,"title":["COPPER DEFICIENCY IN THE RAT EFFECT ON SYNTHESIS OF PHOSPHOLIPIDS"],"prefix":"10.1111","volume":"49","author":[{"given":"CH","family":"Gallagher","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology, University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivienne E","family":"Reeve","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1971,2]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1971.3","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb19713","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb19713.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1971.3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb19713.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T16:09:12Z","timestamp":1696003752000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1971.3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1971,2]]}},"alternative-id":["10.1038\/icb.1971.3"],"URL":"https:\/\/doi.org\/10.1038\/icb.1971.3","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1971,2]]}}}