{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:17:29Z","timestamp":1760897849884},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1971,10,1]],"date-time":"1971-10-01T00:00:00Z","timestamp":55123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1971,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Copper deficiency in the rat has been found not to alter significantly the total phospholipids of liver or brain. However, in agreement with their defective capacity to synthesize phospholipid. liver mitochondria from copper deficient rats contain significantly less phospholipid than do control mitochondria. The qualitative contort of specific phospholipids in liver or brain homogenates or in liver mitochondria is not changed by copper deficiency, indicating that the effect on phospholipid synthesis is general rather than on the synthesis of a specific phospholipid. The proportion of phospholipids present in liver and brain of control or copper\u2010deficient rats on the special diet does not differ from that of siblings raised on a stock pellet diet. Liver mitochondria from copper\u2010 deficient rats contain significantly more polyunsaturated fatty acids than do control liver mitochondria.<\/jats:p><jats:p>The decrease in total phospholipid and the increase in polyunsaturated fatty acids of copper\u2010deficient liver mitochondria are discussed in relation to cytochrome oxidase activity, mitochondrial permeability and the affinity of mitochondrial mombranes to bind and transport ATP. It is concluded that copper deficiency influences phospholipid synthesis by liver mitochondria <jats:italic>in vivo<\/jats:italic> as well as <jats:italic>in vitro.<\/jats:italic><\/jats:p>","DOI":"10.1038\/icb.1971.49","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T09:30:46Z","timestamp":1196155846000},"page":"453-461","source":"Crossref","is-referenced-by-count":18,"title":["COPPER DEFICIENCY IN THE RAT. EFFECT ON LIVER AND BRAIN LIPIDS"],"prefix":"10.1111","volume":"49","author":[{"given":"CH","family":"Gallagher","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology, University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivienne E","family":"Reeve","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1971,10]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1971.49","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb197149","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb197149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1971.49","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb197149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T12:25:19Z","timestamp":1695990319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1971.49"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,10]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1971,10]]}},"alternative-id":["10.1038\/icb.1971.49"],"URL":"https:\/\/doi.org\/10.1038\/icb.1971.49","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1971,10]]}}}