{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T23:26:10Z","timestamp":1699572370108},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1972,8,1]],"date-time":"1972-08-01T00:00:00Z","timestamp":81475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[1972,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Neonatally thymectomised rats, infected with <jats:italic>N. brasiliensis<\/jats:italic>, showed significant increases in worm\u2010egg production and parasite survival when compared with sham\u2010thymectomised controls, particularly during the later stages of infection. Treatment of infected rats with rabbit anti\u2010rat thymocyte serum resulted in a highly significant suppression of parasite rejection. The production of reagin\u2010like antibody, directed at antigens of <jats:italic>N. brasiliensis<\/jats:italic>, was substantially inhibited in both neonatally thymectomised and anti\u2010rat thymocyte serum treated rats.<\/jats:p><jats:p>Neonatal thymectomy combined with anti\u2010rat thymocyte serum treatment, produced a much greater loss of resistance (as judged by worm\u2010egg production and parasite survival) than either neonatal thymectomy or anti\u2010rat thymocyte serum alone. Furthermore, reagin\u2010like antibody production was not detected at any stage during primary infection in neonatally thymectomised, anti\u2010rat thymocyte serum treated rats.<\/jats:p><jats:p>It is suggested that the lymphocytes involved in the lymphocyte\u2010mediated component of resistance of rats to <jats:italic>N. brasiliensis<\/jats:italic> infection are (a) long\u2010lived and (b) derived from and continually produced by the thymus, or are produced elsewhere and the presence of the thymus is essential for their functional development.<\/jats:p>","DOI":"10.1038\/icb.1972.40","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T09:34:15Z","timestamp":1196156055000},"page":"477-489","source":"Crossref","is-referenced-by-count":12,"title":["IMMUNOLOGICAL SUPPRESSION OF PARASITE REJECTION BY REMOVAL OF SELECTED LYMPHOCYTE POPULATIONS: THE EFFECT OF NEONATAL THYMECTOMY AND ANTI\u2010THYMOCYTE SERUM ADMINISTRATION ON THE RESISTANCE OF RATS TO INFECTION WITH THE NEMATODE, <i>NIPPOSTRONGYLUS BRASILIENSIS<\/i>"],"prefix":"10.1111","volume":"50","author":[{"given":"JD","family":"Kelly","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology, University of Sydney Sydney Australia 2006"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1972,8]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1972.40","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb197240","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb197240.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1972.40","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb197240.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T10:38:08Z","timestamp":1695983888000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1972.40"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,8]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1972,8]]}},"alternative-id":["10.1038\/icb.1972.40"],"URL":"https:\/\/doi.org\/10.1038\/icb.1972.40","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1972,8]]}}}