{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:24:54Z","timestamp":1771626294270,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1974,2,1]],"date-time":"1974-02-01T00:00:00Z","timestamp":128908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1974,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Rabbit ear arteries were depleted of noradrenaline by prior treatment with reserpine.<\/jats:p><jats:p>Following inhibition of monoamine oxidase, extraluminal noradrenaline caused the reappearance of monoamine fluorescence at the media\u2010adventitia border.<\/jats:p><jats:p>Cocaine prevented the appearance of fluorescence, indicating that the latter was probably due to uptake of noradrenaline by the sympathetic nerves.<\/jats:p><jats:p>Intraluminal noradrenaline failed to restore fluorescence unless meta\u2010nephrine or the catechol\u2010o\u2010methyl transferase inhibitor U0521 was also present.<\/jats:p><jats:p>The results are interpreted as evidence (i) that intraluminal noradrenaline does not penetrate as readily as extraluminal noradrenaline to the sympathetic nerves; (ii) that the difference in penetration is due to loss of intraluminal noradrenaline in the media resulting from its uptake and inactivation by the smooth muscle.<\/jats:p><jats:p>The finding that extraluminal noradrenaline does not restore fluorescence in the absence of monoamine oxidase inhibition provides further evidence that part of the monoamine oxidase in the artery wall is intimately associated with the sympathetic nerves.<\/jats:p>","DOI":"10.1038\/icb.1974.16","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T09:40:43Z","timestamp":1196156443000},"page":"193-200","source":"Crossref","is-referenced-by-count":8,"title":["HISTOCHEMICAL ANALYSIS OF THE DIFFUSION OF NORADRENALINE ACROSS THE ARTERY WALL"],"prefix":"10.1111","volume":"52","author":[{"given":"IS","family":"De La Lande","sequence":"first","affiliation":[{"name":"Departments of Human Physiology and Pharmacology, and of Oral Biology, The University of Adelaide Adelaide"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LB","family":"Jellett","sequence":"additional","affiliation":[{"name":"Departments of Human Physiology and Pharmacology, and of Oral Biology, The University of Adelaide Adelaide"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret A","family":"Lazner","sequence":"additional","affiliation":[{"name":"Departments of Human Physiology and Pharmacology, and of Oral Biology, The University of Adelaide Adelaide"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAS","family":"Parker","sequence":"additional","affiliation":[{"name":"Departments of Human Physiology and Pharmacology, and of Oral Biology, The University of Adelaide Adelaide"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JG","family":"Waterson","sequence":"additional","affiliation":[{"name":"Departments of Human Physiology and Pharmacology, and of Oral Biology, The University of Adelaide Adelaide"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1974,2]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1974.16","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb197416","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb197416.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1974.16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb197416.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T06:06:51Z","timestamp":1695967611000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1974.16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1974,2]]}},"alternative-id":["10.1038\/icb.1974.16"],"URL":"https:\/\/doi.org\/10.1038\/icb.1974.16","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1974,2]]}}}