{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T17:51:57Z","timestamp":1699638717704},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1975,6,1]],"date-time":"1975-06-01T00:00:00Z","timestamp":170812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1975,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Antiviral activity <jats:italic>in vivo<\/jats:italic> exerted by ectromelia virus\u2010immune spleen cells transferred to ectromelia\u2010infected recipients and cytotoxicity against virus\u2010infected target cells <jats:italic>in vitro<\/jats:italic> were both properties of non\u2010immunoglobulin (Ig)\u2010bearing cells (which included T cells). Ig\u2010bearing cells, including thymus\u2010independent (B) cells and antibody\u2010secreting cells, were much less active <jats:italic>in vivo<\/jats:italic> when injected alone and tended to block rather than amplify the effect triggered by T cells. Ig\u2010bearing cells were also slightly active <jats:italic>in vitro<\/jats:italic>, possibly because some T cells have detectable Ig. Antiviral effects in cell transfer experiments were seen only when immune cell donors and infected recipients shared the same H\u20102 gene complex. These results are consistent with the hypothesis that the T cell response to ectromelia infection is directed against specific virus\u2010induced change(s) in antigen(s), specified by gene(s) in the H\u20102 complex, which appear in virus\u2010infected cells.<\/jats:p>","DOI":"10.1038\/icb.1975.19","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T09:45:49Z","timestamp":1196156749000},"page":"187-195","source":"Crossref","is-referenced-by-count":22,"title":["EFFECTS OF THYMUS\u2010INDEPENDENT (B) CELLS AND THE H\u20102 GENE COMPLEX ON ANTIVIRAL FUNCTION OF IMMUNE THYMUS\u2010DERIVED (T) CELLS"],"prefix":"10.1111","volume":"53","author":[{"given":"Robert V","family":"Blanden","sequence":"first","affiliation":[{"name":"Department of Microbiology, John Curtin School of Medical Research, Australian National University Canberra A.C.T. 2600"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narelle A","family":"Bowern","sequence":"additional","affiliation":[{"name":"Department of Microbiology, John Curtin School of Medical Research, Australian National University Canberra A.C.T. 2600"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tikky E","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, John Curtin School of Medical Research, Australian National University Canberra A.C.T. 2600"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian D","family":"Gardner","sequence":"additional","affiliation":[{"name":"Department of Microbiology, John Curtin School of Medical Research, Australian National University Canberra A.C.T. 2600"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R","family":"Parish","sequence":"additional","affiliation":[{"name":"Department of Microbiology, John Curtin School of Medical Research, Australian National University Canberra A.C.T. 2600"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1975,6]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1975.19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb197519","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb197519.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1975.19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb197519.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T23:47:58Z","timestamp":1696031278000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1975.19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,6]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1975,6]]}},"alternative-id":["10.1038\/icb.1975.19"],"URL":"https:\/\/doi.org\/10.1038\/icb.1975.19","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1975,6]]}}}