{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:03:42Z","timestamp":1758636222676},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1977,4,1]],"date-time":"1977-04-01T00:00:00Z","timestamp":228700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1977,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Various inbred strains of mice vary markedly in their susceptibility to the larvae of the cestode, <jats:italic>Taenia taeniaeformis<\/jats:italic>. Males are generally more susceptible than females and the most susceptible common inbred mouse strains are those which are deficient in C5 and\/or C4 components of complement. However, no <jats:italic>genetic<\/jats:italic> evidence is yet available to implicate loci controlling complement levels in susceptibility\/resistance, and multiple genetic factors appear to be operative. Hypothymic, nu\/nu (\u201cnude\u201d) mice of the relatively resistant mouse strain, BALB\/c, are highly susceptible in that cystic larvae in the liver develop in large numbers and more rapidly than in intact BALB\/c.nu\/+ littermates. Cyclophosphamide pretreatment also increases the susceptibility of relatively resistant strains of mice in terms of both the number and size of liver cysts. Hypothymic and intact mice can be protected, absolutely, by an injection of serum from infected intact mice, provided the serum is given to recipient mice close to the time of oral egg administration. The protective activity of immune serum is absorbed totally by staphylococcal protein A\u2010Sepharose columns and can be abolished by treatment of recipients with cobra venom factor. Cyst fluid from established larvae <jats:italic>facilitates<\/jats:italic> the activity of subhaemolytic amounts of guinea pig complement in a standard direct PFC assay. The data suggest that complement\u2010fixing antibodies are responsible for inhibition of establishing larvae in mice and that one method of protection for established cystic larvae involves the alteration of host complement activity within the cyst.<\/jats:p>","DOI":"10.1038\/icb.1977.13","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T10:23:20Z","timestamp":1196159000000},"page":"165-186","source":"Crossref","is-referenced-by-count":87,"title":["STUDIES ON IMMUNE RESPONSES TO LARVAL CESTODES IN MICE. INCREASED SUSCEPTIBILITY OF CERTAIN MOUSE STRAINS AND HYPOTHYMIC MICE TO <i>TAENlA TAENIAEFORMIS<\/i> AND ANALYSIS OF PASSIVE TRANSFER OF RESISTANCE WITH SERUM"],"prefix":"10.1111","volume":"55","author":[{"given":"Graham F","family":"Mitchell","sequence":"first","affiliation":[{"name":"Walter and Eliza Hall Institute, Royal Melbourne Hospital P.O. Victoria, 3050 Australia"},{"name":"University of Melbourne Veterinary Clinical Centre Princes Highway Werribee Victoria, 3030 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James W","family":"Goding","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Institute, Royal Melbourne Hospital P.O. Victoria, 3050 Australia"},{"name":"University of Melbourne Veterinary Clinical Centre Princes Highway Werribee Victoria, 3030 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D","family":"Rickard","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Institute, Royal Melbourne Hospital P.O. Victoria, 3050 Australia"},{"name":"University of Melbourne Veterinary Clinical Centre Princes Highway Werribee Victoria, 3030 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1977,4]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1977.13","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb197713","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb197713.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1977.13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb197713.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T19:33:36Z","timestamp":1696016016000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1977.13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,4]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1977,4]]}},"alternative-id":["10.1038\/icb.1977.13"],"URL":"https:\/\/doi.org\/10.1038\/icb.1977.13","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1977,4]]}}}