{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T19:32:25Z","timestamp":1699644745050},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1977,2,1]],"date-time":"1977-02-01T00:00:00Z","timestamp":223603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1977,2]]},"abstract":"Summary<\/jats:title>Lysis of virus\u2010infected target cells by virus\u2010specific cytotoxic T cells occurs only where donors of T cells and targets share either H\u20102K<\/jats:italic> or H\u20102D<\/jats:italic> genes. The effect of four H\u20102K<\/jats:italic> mutations on virus\u2010induced antigens recognized by cytotoxic T cells from an in vitro<\/jats:italic> secondary response to infection was studied. B10.A(5R) cytotoxic T cells (which share the K<\/jats:italic> end of H\u20102<\/jats:italic> with the mutant strains, except for the mutated gene(s)) efficiently kitted virus\u2010infected macrophage targets from mutant strains B6\u2010H\u20102bg1<\/jats:sup> and B6\u2010H\u20102bg2<\/jats:sup>, were less effective against B6\u2010H\u20102bh<\/jats:sup><\/jats:italic> and did not appear to be cytotoxic for B6.C\u2010H\u20102ba<\/jats:sup><\/jats:italic> target cells. Conversely, B6\u2010H\u20102bg1<\/jats:sup> and B6\u2010H\u20102bg2<\/jats:sup> cytotoxic T cells were more effective in killing virus\u2010infected B10.A(5R) macrophages than B6\u2010H\u20102bh<\/jats:sup><\/jats:italic> and B6.C\u2010H\u20102ba<\/jats:sup><\/jats:italic> cytotoxic cells respectively. In addition, B6\u2010H\u20102bg1<\/jats:sup><\/jats:italic> and B6\u2010H\u20102bg2<\/jats:sup><\/jats:italic> cells appeared to be only slightly different from wild\u2010type with respect to the interaction between virus\u2010infected cells and T cells. The data obtained suggested that virus\u2010induced antigenic patterns on infected B6.C\u2010H\u20102ba<\/jats:sup><\/jats:italic> (mutant) cells are more different antigenically from those on wild\u2010type cells than are those on infected cells from the other mutants, B6\u2010H\u20102bh<\/jats:sup><\/jats:italic>, B6\u2010H\u20102bg1<\/jats:sup> and B6\u2010H\u20102bg2<\/jats:sup>. This agrees with previous data using primary cytotoxic T cells and thus suggests that no detectable change in the affinity or specificity of cytotoxic T cell receptors occurs between primary and secondary responses to infection. These findings are also discussed in relation to the exclusion of T cells with receptors for H\u20102K<\/jats:italic> determinants that are common to the mutants and wild\u2010type, from the response to virus\u2010infected self cells.<\/jats:p>","DOI":"10.1038\/icb.1977.4","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T09:54:47Z","timestamp":1196157287000},"page":"39-48","source":"Crossref","is-referenced-by-count":8,"title":["SPECIFICITY OR AFFINITY OF CYTOTOXIC T CELLS FOR SELF H\u20102K DETERMINANTS APPARENTLY DOES NOT CHANGE BETWEEN PRIMARY AND SECONDARY RESPONSES TO ECTROMELIA VIRUS INFECTION"],"prefix":"10.1111","volume":"55","author":[{"given":"Tikky","family":"Pang","sequence":"first","affiliation":[{"name":"Department of Microbiology, John Curtin School of Medical Research, Australian National University Canberra A.C.T. 2601"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion E","family":"Andrew","sequence":"additional","affiliation":[{"name":"Department of Microbiology, John Curtin School of Medical Research, Australian National University Canberra A.C.T. 2601"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger W","family":"Melvold","sequence":"additional","affiliation":[{"name":"Department of Microbiology, John Curtin School of Medical Research, Australian National University Canberra A.C.T. 2601"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert V","family":"Blanden","sequence":"additional","affiliation":[{"name":"Department of Microbiology, John Curtin School of Medical Research, Australian National University Canberra A.C.T. 2601"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1977,2]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1977.4","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb19774","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb19774.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1977.4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb19774.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T14:31:20Z","timestamp":1695997880000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1977.4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,2]]}},"alternative-id":["10.1038\/icb.1977.4"],"URL":"https:\/\/doi.org\/10.1038\/icb.1977.4","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1977,2]]}}}