{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T05:26:00Z","timestamp":1696051560663},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1977,10,1]],"date-time":"1977-10-01T00:00:00Z","timestamp":244512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[1977,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The nature of infected stimulator cells in the <jats:italic>in vitro<\/jats:italic> secondary cytotoxic T cell response to ectromelia infection was investigated. It was found that macrophages were better stimulator cells than spleen cells. B cells (Ig\u2010positive cells) were superior to T cells (Ig\u2010negative cells) both on a relative proportion and on a cell\u2010to\u2010cell basis. Concanavalin A and lipopolysaccharide\u2010stimulated lymphocytes were also effective stimulator cells but appeared to be slightly inferior to spleen cells. Spleen cells depleted of la\u2010positive cells were markedly inferior to normal spleen cells as stimulators. It was also found that primary and secondary cytotoxic T cells were largely Ia\u2010negative.<\/jats:p><jats:p>These findings are discussed in relation to the likely events during T cell responses to infection <jats:italic>in vivo.<\/jats:italic><\/jats:p>","DOI":"10.1038\/icb.1977.53","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T09:57:07Z","timestamp":1196157427000},"page":"539-547","source":"Crossref","is-referenced-by-count":2,"title":["REQUIREMENTS FOR STIMULATION OF T CELL RESPONSES AGAINST VIRUS\u2010INFECTED CELLS: NATURE OF ECTROMELIA VIRUS\u2010INFECTED CELLS CAPABLE OF STIMULATING CYTOTOXIC T CELLS IN A SECONDARY RESPONSE <i>IN VITRO<\/i>"],"prefix":"10.1111","volume":"55","author":[{"given":"T","family":"Pang","sequence":"first","affiliation":[{"name":"Department of Microbiology, John Curtin School of Medical Research, Australian National University Canberra, 2601 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RV","family":"Blanden","sequence":"additional","affiliation":[{"name":"Department of Microbiology, John Curtin School of Medical Research, Australian National University Canberra, 2601 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1977,10]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1977.53","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb197753","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb197753.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1977.53","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb197753.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T02:34:44Z","timestamp":1696041284000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1977.53"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,10]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1977,10]]}},"alternative-id":["10.1038\/icb.1977.53"],"URL":"https:\/\/doi.org\/10.1038\/icb.1977.53","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1977,10]]}}}