{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T09:49:43Z","timestamp":1696067383896},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1978,2,1]],"date-time":"1978-02-01T00:00:00Z","timestamp":255139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1978,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Virus\u2010immune memory T cells from A.TL mice <jats:italic>(K<jats:sup>8<\/jats:sup>, D<jats:sup>d<\/jats:sup>)<\/jats:italic> stimulated <jats:italic>in vitro<\/jats:italic> by ectromelia\u2010infected BALB\/c macrophages <jats:italic>(K<jats:sup>d<\/jats:sup>, D<jats:sup>d<\/jats:sup>)<\/jats:italic> gave rise to the subset of cytotoxic T cells that recognized virus plus H\u20102D<jats:sup>d<\/jats:sup> and lysed infected BALB\/c, not infected SJL\/J (<jats:italic>K<jats:sup>8<\/jats:sup>, D<jats:sup>8<\/jats:sup>)<\/jats:italic> targets, despite cultural conditions which ensured that the responding A.TL cells were also in contact with the H\u20102K<jats:sup>8<\/jats:sup> antigen (on other, adjacent A.TL cells). The converse results were obtained using SJL\/J infected stimulators. Thus, it seemed that viral and H\u20102K or H\u20102D antigens must be in the same cell surface membrane, probably in physical association, to produce antigen moieties that stimulated virus\u2010immune T cells, These results implied that functional pairs of hypothetical recognition structures for viral and H\u20102 determinants would need to be associated in some way in the memory T cell membrane.<\/jats:p><jats:p>A second experimental approach further explored this hypothesis. C57BL\/6 and B6.C\u2010<jats:italic>H\u20102<jats:sup>ba<\/jats:sup><\/jats:italic> mice differ because of a gain\u2010loss mutation in the <jats:italic>H\u20102K<\/jats:italic> region, apparently in a cistron coding for an H\u20102K<jats:sup>b<\/jats:sup> polypeptide antigen. Mutant and wild\u2010type share H\u20102K<jats:sup>b<\/jats:sup> determinant(s) recognizable by allogeneic cytotoxic T cells, in addition to possessing unique determinant(s) defined by the mutation. Virus\u2010immune cytotoxic T cells, syngeneic with respect to infected stimulator cells, apparently recognize the unique determinant (s) but are not stimulated by. or do not recognize the shared determinant(s). despite the presence of the latter on virus\u2010infected cells as demonstrated by lysis of infected targets by mixed lymphocyte reactions (MLR)\u2010generated T cells directed only at the shared determinants. These results are discussed in terms of two alternative, but not mutually exclusive, hypotheses. The first suggests that physical association between viral and H\u20102K molecules may result in certain H\u20102K determinants being \u201cmasked\u201d or inaccessible to T cell receptors, thus rendering them unable to stimulate T cell responses. It would again follow that the T cell recognition structures for viral and H\u20102 determinants would also need to be associated in some way. An alternative is that the shared determinants revealed by the cross\u2010reactivity of allogeneic cytotoxic T cells generated in MLR are not encompassed in the dictionary of receptors on syngeneic T cells that recognize, and are stimulated by, virus\u2010infected self cells.<\/jats:p>","DOI":"10.1038\/icb.1978.8","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T10:00:21Z","timestamp":1196157621000},"page":"69-80","source":"Crossref","is-referenced-by-count":2,"title":["CYTOTOXIC T CELL RECOGNITION OF ECTROMELIA VIRUS\u2010INFECTED CELLS."],"prefix":"10.1111","volume":"56","author":[{"given":"Robert V","family":"Blanden","sequence":"first","affiliation":[{"name":"Department of Microbiology, The John Curtin School of Medical Research, Australian National University Canberra A.C.T Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tikky","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The John Curtin School of Medical Research, Australian National University Canberra A.C.T Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1978,2]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1978.8","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb19788","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb19788.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1978.8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb19788.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T03:25:02Z","timestamp":1695957902000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1978.8"}},"subtitle":["ARE RECEPTORS FOR VIRAL AND H\u20102 DETERMINANTS CLOSELY ASSOCIATED?"],"short-title":[],"issued":{"date-parts":[[1978,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1978,2]]}},"alternative-id":["10.1038\/icb.1978.8"],"URL":"https:\/\/doi.org\/10.1038\/icb.1978.8","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1978,2]]}}}