{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T09:01:43Z","timestamp":1770714103328,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1979,2,1]],"date-time":"1979-02-01T00:00:00Z","timestamp":286675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1979,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The course of the disease, cutaneous leishmaniasis, caused by the intracellular protozoan parasite <jats:italic>Leishmania tropica<\/jats:italic>, differs markedly amongst various common inbred mouse strains. After intradermal injection of 1 \u00d7 10<jats:sup>6<\/jats:sup> promastigotes to young female specific pathogen\u2010free (SPF) derived mice, persistent infection characterized by an expanding ulcerous lesion is seen in BALB\/c and DBA\/2 mice. In the strains CBA\/H, C3H\/He and A\/J, lesions resolve within 8 weeks, and in C57Bl\/6 mice no real lesion typical of cutaneous leishmaniasis develops at the injection site. NZB mice are highly resistant. Macrophages harvested from the thioglycollate\u2010stimulated peritoneal cavity of NZB and C57Bl\/6 mice appear to differ from macrophages of the other mouse strains in not supporting multiplication of <jats:italic>L. tropica<\/jats:italic> organisms <jats:italic>in vitro<\/jats:italic>. Nevertheless, hypothymic nude (nu\/nu) mice of C57B1\/6 genotype, as well as CBA\/H\u2010nu\/nu and BALB\/c\u2010nu\/nu mice, develop large lesions with metastases to other cutaneous and visceral locations. In the intact mice in which infection resolves spontaneously, resistance to reinfection is complete. Using mouse antipromastigote sera and an indirect fluorescent antibody test in carefully controlled experiments, L. tropica antigens were detected on in vitro infected macrophages of both highly susceptible BALB\/c and relatively resistant CBA\/H genotypes. After incubation with a crude soluble antigen preparation from cultured promastigotes, infected macrophages of both genotypes) in being unable to sensitize syngeneic recipients for a delayed\u2010type hypersensitivity response to that antigen. When infected and uninfected macrophages were used as \u201cblocking cell\u201d in an <jats:italic>in vitro<\/jats:italic> alloreactive cytotoxic T cell system involving cells from congenic mice, evidence was obtained for reduced H\u20102<jats:sup>d<\/jats:sup> expression on infected macrophages of the susceptible mouse strain, BALB\/c. The data in this model system of cutaneous leishmaniasis raise the possibility that genetic susceptibility is associated with both a permissive macrophage and defective T cell recognition of parasite antigens on infected macrophage. Defective recognition may be the result of reduced functional expression of H\u20102<jats:sup>d<\/jats:sup> antigens on infected BALB\/c macrophages required for efficient recognition by syngeneic T cells of one or more sub\u2010populations.<\/jats:p>","DOI":"10.1038\/icb.1979.2","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T10:04:02Z","timestamp":1196157842000},"page":"9-29","source":"Crossref","is-referenced-by-count":166,"title":["MURINE CUTANEOUS LEISHMANIASIS: DISEASE PATTERNS IN INTACT AND NUDE MICE OF VARIOUS GENOTYPES AND EXAMINATION OF SOME DIFFERENCES BETWEEN NORMAL AND INFECTED MACROPHAGES"],"prefix":"10.1111","volume":"57","author":[{"given":"Emanuela","family":"Handman","sequence":"first","affiliation":[{"name":"Laboratory of Immunoparasitology, The Water and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital P.O. Victoria 3050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhodri","family":"Ceredig","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoparasitology, The Water and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital P.O. Victoria 3050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham F","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoparasitology, The Water and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital P.O. Victoria 3050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1979,2]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"Allison AC Bloom BR Brunner T Godal T Mackaness GB McGregor DD Nelson DS andTurk JL(1973):\u201cCell\u2010mediated immunity and resistance to infection\u201d Technical Report Series World Health Organization No. 519 p.1."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1978.8"},{"key":"e_1_2_1_4_1","first-page":"130","article-title":"\u2018Regulation of Leishmania population within the host. II. Genetic control of acute susceptibilty of mice to Leishmania donovani infections.\u2019","volume":"30","author":"Bradley DJ","year":"1977","journal-title":"Din. Exp. Immunol."},{"key":"e_1_2_1_5_1","first-page":"119","article-title":"\u2018Regulation of Leishmania populations. within the host. I. The variable course of Leishmania donovani infections in mice.\u2019","volume":"30","author":"Bradley DJ","year":"1977","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(75)90090-3"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(75)90069-6"},{"key":"e_1_2_1_8_1","unstructured":"1974 Academic Press New York C Cowing M Lukic S Leskowitz D. H. Katz B. Benaecrraf \u2018The cellular basis for establishing tolerance or immunity to bovine \u03b3\u2010globulin in mice.\u2019 61"},{"key":"e_1_2_1_9_1","first-page":"89","article-title":"\u201cSpecificity of virus\u2010immune effector T cells\u2010 for H\u20102K and H\u20102D compatible interactions: implications for H\u2010antigen diversity.\u201d","volume":"29","author":"Doherty PC","year":"1976","journal-title":"Trans\u2010plant. Rev."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(76)90068-5"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000231295"},{"key":"e_1_2_1_12_1","first-page":"389","article-title":"\u2018Studies on the induction of immunological unresponsiveness. III. Antigen form and mouse strain variation.\u2019","volume":"102","author":"Golub ES","year":"1969","journal-title":"J. Immunol."},{"key":"e_1_2_1_13_1","unstructured":"1977 Hebrew University Hadassah Medical School Jerusalem E Handman In vivo and in vitro Examination of immunological processes in leishmaniasis.\u201d"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00383117"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.146.1.146"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.10.4.578-585.1972"},{"key":"e_1_2_1_17_1","unstructured":"1974 Associated Scientific Amsterdam JG Hirsch TC Jones L Len R. Porter J. Knight \u2018Interactions in vitro between Toxoplasma gondi and mouse cells.\u2019 205"},{"key":"e_1_2_1_18_1","first-page":"175","article-title":"\u2018The function and inter\u2010relationship of T cell receptors, In genes and other histocompatibility gene products.\u2019","volume":"22","author":"Katz DH","year":"1975","journal-title":"Transplant. Rev."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/257596a0"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(77)90269-6"},{"key":"e_1_2_1_21_1","unstructured":"1974 Associated Scientific Amsterdam J Mauel B Behin Noerjosin Biroum JJ Doyle R. Porter J. Knight \u2018Survival and death of Leishmania in macrophages.\u2019 225"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1977.26.170"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.147.2.470"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1977.tb02150.x"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000231670"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000231775"},{"key":"e_1_2_1_27_1","article-title":"\u2018The allergenicity of concanavalin A in mice.\u2019","author":"Mitchell GF","year":"1978","journal-title":"Int. Arch. Allergy Appl. Immunol."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000231669"},{"key":"e_1_2_1_29_1","first-page":"121","article-title":"\u2018Culture des corps de Leishman isol\u00e9s de la rate flans trois cas d'anemie splenique infantile.\u2019","volume":"1","author":"Nicolle C","year":"1908","journal-title":"Bull. Soc. Path. Exot."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591577306600822"},{"key":"e_1_2_1_31_1","first-page":"126","article-title":"\u2018Experimenthal cutaneous leishminiasis, V. Protective immunity in subclinical and self health infection in the mouse.\u2019","volume":"23","author":"Preston PM","year":"1976","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_32_1","first-page":"337","article-title":"\u2018Experimental cutaneous leish\u2010maniasis. III. Effects of thymectomy on the course of infection of CBA mice with Leishmania tropica.\u2019","volume":"10","author":"Preston PM","year":"1972","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(77)80485-7"},{"key":"e_1_2_1_34_1","unstructured":"1975 Wiley New York DT Spira H Rabinowith A. Zuckerman \u2018Host\u2010parasite relationships in cutaneous leishmaniasis.\u2019 177"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60185-6"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000231449"},{"key":"e_1_2_1_37_1","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.4049\/jimmunol.118.6.2288","article-title":"\u2018The effect of BCG on experimental cutaneous leishmaniasis in mice.\u2019","volume":"118","author":"Weintraub J","year":"1977","journal-title":"J. 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