{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T15:30:36Z","timestamp":1699630236847},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1979,8,1]],"date-time":"1979-08-01T00:00:00Z","timestamp":302313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1979,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Mice chronically infected with 3 metazoan and 1 protozoan parasite contain in their circulation levels of IgG<jats:sub>1<\/jats:sub> which are increased over the levels in uninfected mice by at least 10\u00d7. In the case of infection with the larval cestode, <jats:italic>Mesocestoides corti<\/jats:italic>. the serum IgG<jats:sub>1<\/jats:sub> concentration can reach &gt; 50 mg\/ml and, with a half\u2010life of &lt; 2 days, the number of cells engaged in IgG<jats:sub>1<\/jats:sub> production is approximately 2 \u00d7 10<jats:sup>8<\/jats:sup>. The IgG<jats:sub>1<\/jats:sub> hypergammaglobulinaemia is not seen in infected hypothymic nude mice. Biosynthetic labelling studies with organ and tissue cultures established that in two of the chronic infections the organs principally involved in IgG<jats:sub>1<\/jats:sub> synthesis were those pathologically involved or those \u201cin line\u201d for antigen capture: i.e. liver and spleen in the case of M. corti which is located in the liver and the peritoneal cavity, and various intestinal lymph nodes in the case of the gut\u2010dwelling nematode, <jats:italic>Nematospiroides dubius<\/jats:italic>. This apparently exaggerated response to chronic parasitic infection is of interest simply because of the potential magnitude of the effect and the fact that it involves an Ig isotype with very poorly defined biological function.<\/jats:p>","DOI":"10.1038\/icb.1979.38","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T10:05:45Z","timestamp":1196157945000},"page":"369-387","source":"Crossref","is-referenced-by-count":33,"title":["IgG<sub>1<\/sub> HYPERGAMMAGLOBULINAEMIA IN CHRONIC PARASITIC INFECTIONS IN MICE: MAGNITUDE OF THE RESPONSE IN MICE INFECTED WITH VARIOUS PARASITES"],"prefix":"10.1111","volume":"57","author":[{"given":"Colin B","family":"Chapman","sequence":"first","affiliation":[{"name":"Laboratory of Immunoparasitology, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital P.O. Victoria 3050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul M","family":"Knopf","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoparasitology, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital P.O. Victoria 3050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Douglas","family":"Hicks","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoparasitology, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital P.O. Victoria 3050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham F","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoparasitology, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital P.O. Victoria 3050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1979,8]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1979.38","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb197938","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb197938.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1979.38","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb197938.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T08:35:27Z","timestamp":1695976527000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1979.38"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,8]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1979,8]]}},"alternative-id":["10.1038\/icb.1979.38"],"URL":"https:\/\/doi.org\/10.1038\/icb.1979.38","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1979,8]]}}}