{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:41:56Z","timestamp":1759333316582},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1979,8,1]],"date-time":"1979-08-01T00:00:00Z","timestamp":302313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1979,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Tbe IgG<jats:sub>1<\/jats:sub> molecules in the sera of IgG<jats:sub>1<\/jats:sub> hypergammaglobulinaemic mice chronically infected with the larval cestode, <jats:italic>Mesocestoides corti<\/jats:italic>, are a heterogeneous population. Although antibodies to <jats:italic>M. corti<\/jats:italic> are present, the question of whether a minority or majority of the serum IgG<jats:sub>1<\/jats:sub> molecules has anti\u2010parasite reactivity remains open. The splenic PFC response to an intravenous injection of SRBC in <jats:italic>M. corti<\/jats:italic>\u2010infected mice does not consist of an unusually high proportion of IgG<jats:sub>1<\/jats:sub> anti\u2010SRBC PFC. Moreover, the adoptive anti\u2010DNP PFC response of spleen cells from M. corti\u2010infected mice to DNP\u2010<jats:italic>M. corti<\/jats:italic> is not biased towards IgG<jats:sub>1<\/jats:sub> antibody production.<\/jats:p><jats:p>Since IgG<jats:sub>1<\/jats:sub> hypergammaglobulinaemia is seen in mice with chronic, \u201chigh\u2010dose\u201d infections, an attempt has been made to simulate chronic antigenic exposure with SRBC in uninfected mice. A split, high\u2010dose regime of SRBC injections leads to a high number and high proportion of IgG<jats:sub>1<\/jats:sub> anti\u2010SRBG PFC in the spleen in three strains of mice. The results suggest that the extraordinarily high levels of IgC<jats:sub>1<\/jats:sub> seen in the sera of mice chronically infected with the metazoan, <jats:italic>M. corti<\/jats:italic> and <jats:italic>Nematospiroides dubius<\/jats:italic>, reflect persistent, high\u2010dose, \u201cstrong\u201d. T cell\u2010dependent stimulation of the B cell system.<\/jats:p>","DOI":"10.1038\/icb.1979.39","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T10:05:45Z","timestamp":1196157945000},"page":"389-400","source":"Crossref","is-referenced-by-count":23,"title":["IgG<sub>1<\/sub> HYPERGAMMAGLOBULINAEMIA IN CHRONIC PARASITIC INFECTIONS IN MICE: EVIDENCE THAT THE RESPONSE REFLECTS CHRONICITY OF ANTIGEN EXPOSURE"],"prefix":"10.1111","volume":"57","author":[{"given":"Colin B","family":"Chapman","sequence":"first","affiliation":[{"name":"Laboratory of Immunoparasitology, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital P.O. Victoria 3050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul M","family":"Knopf","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoparasitology, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital P.O. Victoria 3050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin F","family":"Anders","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoparasitology, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital P.O. Victoria 3050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham F","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoparasitology, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital P.O. Victoria 3050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1979,8]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1979.39","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb197939","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb197939.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1979.39","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb197939.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T08:35:28Z","timestamp":1695976528000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1979.39"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,8]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1979,8]]}},"alternative-id":["10.1038\/icb.1979.39"],"URL":"https:\/\/doi.org\/10.1038\/icb.1979.39","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1979,8]]}}}