{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:09:56Z","timestamp":1787155796474,"version":"build-2736575974"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1979,10,1]],"date-time":"1979-10-01T00:00:00Z","timestamp":307584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1979,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The effect of ketone bodies on the growth, in culture, of transformed lymphoblasts (Raji cells) was investigated. Cell growth was inhibited and this effect was reversible, non\u2010toxic, and proportional to the concentration of D\u2010\u03b2\u2010hydroxybutyrate up to 20mM. The total glucose utilisation and the total lactate production were reduced in proportion to the inhibition of cell proliferation. D\u2010\u03b2\u2010hydroxybutyrate was not metabolised by the cells. Other glycolytic inhibitors and chemical analogues of D\u2010\u03b2\u2010hydroxybutyrate cither did not inhibit or proved to be too toxic for cell growth. D\u2010\u03b2\u2010hydroxybutyrate also inhibited the growth of rabbit kidney (RK.13), HeLa, mouse melanoma (B16), fibroblast and trypsin\u2010dispersed human thyroid and beef testis cells. Moreover, <jats:italic>in vivo<\/jats:italic> dietary\u2010induced ketosis reduced the number of B16 melanoma deposits in the lungs of CS7BL\/6 mice by two\u2010thirds. The significance of these results in the clinical management of cancer cachexia is discussed.<\/jats:p>","DOI":"10.1038\/icb.1979.54","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T10:06:30Z","timestamp":1196157990000},"page":"529-539","source":"Crossref","is-referenced-by-count":70,"title":["THE INHIBITION OF MALIGNANT CELL GROWTH BY KETONE BODIES"],"prefix":"10.1111","volume":"57","author":[{"given":"Barbara A","family":"Magee","sequence":"first","affiliation":[{"name":"Institute or Medical and Veterinary Science Frome Road Adelaide S.A. 5000 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Potezny","sequence":"additional","affiliation":[{"name":"Institute or Medical and Veterinary Science Frome Road Adelaide S.A. 5000 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan M","family":"Rofe","sequence":"additional","affiliation":[{"name":"Institute or Medical and Veterinary Science Frome Road Adelaide S.A. 5000 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert AJ","family":"Conyers","sequence":"additional","affiliation":[{"name":"Institute or Medical and Veterinary Science Frome Road Adelaide S.A. 5000 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1979,10]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1979.54","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb197954","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb197954.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1979.54","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb197954.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:53:05Z","timestamp":1696035185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1979.54"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,10]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1979,10]]}},"alternative-id":["10.1038\/icb.1979.54"],"URL":"https:\/\/doi.org\/10.1038\/icb.1979.54","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1979,10]]}}}