{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:44:45Z","timestamp":1761155085038},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1980,10,1]],"date-time":"1980-10-01T00:00:00Z","timestamp":339206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1980,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>BALB\/c mice differ from CBA\/H, (CBA\/H \u00d7 BALB\/c)F<jats:sub>1<\/jats:sub> and C57BL\/6 mice in being highly susceptible to infection with a particular isolate of the intramacrophage protozoan parasite, <jats:italic>Leishmania tropica.<\/jats:italic> This is true over a wide range of challenge doses of promastigotes administered intradermally although, at low doses, male BALB\/c are able to restrict the rate at which cutaneous lesions increase in size.<\/jats:p><jats:p>Resistance to infection in highly susceptible hypothymic nude (nu\/nu) mice of CBA\/H and C57BL\/6 genotypes can be achieved readily with as few as 10<jats:sup>6<\/jats:sup> syngeneic lymphoid cells. In CBA\/H.nu\/nu mice, Lyl<jats:sup>+<\/jats:sup>2<jats:sup>\u2212<\/jats:sup> cells in low dose cellular inocula appear to be involved in restoring resistance (i.e. rapid resolution of infection). Surprisingly, a proportion of BALB\/c.nu\/nu mice injected with syngeneic lymphoid cells are resistant and thus differ from intact BALB\/c mice or non\u2010reconstituted BALB\/c.nu\/nu mice. In keeping with a high efficacy of limited numbers of T cells following minimal reconstitution, the majority of nude mice implanted subcutaneously with allogeneic, irradiated, neonatal thymus grafts are resistant to <jats:italic>L. tropica<\/jats:italic> infection. Genetic features of the node mouse, such as, a defect in skin, may contribute to the extraordinary potency of T cell reconstitutive manipulations. Evidence was obtained that BALB\/c.nu\/nu skin on BALB\/c.nu\/+ recipients did not support the development of lesions as readily as normal skin sites.<\/jats:p>","DOI":"10.1038\/icb.1980.54","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T10:09:38Z","timestamp":1196158178000},"page":"521-532","source":"Crossref","is-referenced-by-count":66,"title":["CUTANEOUS LEISHMANIASIS IN MICE: DISEASE PATTERNS IN RECONSTITUTED NUDE MICE OF SEVERAL GENOTYPES INFECTED WITH <i>LEISHMANIA TROPICA<\/i>"],"prefix":"10.1111","volume":"58","author":[{"given":"Graham F","family":"Mitchell","sequence":"first","affiliation":[{"name":"Department of Immunology, John Curtin School of Medical Research, Australian National University P.O. Box 334 Canberra City A.C.T. 2601"},{"name":"Department of Medicine, Austin Hospital Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan M","family":"Curtis","sequence":"additional","affiliation":[{"name":"Department of Immunology, John Curtin School of Medical Research, Australian National University P.O. Box 334 Canberra City A.C.T. 2601"},{"name":"Department of Medicine, Austin Hospital Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Handman","sequence":"additional","affiliation":[{"name":"Department of Immunology, John Curtin School of Medical Research, Australian National University P.O. Box 334 Canberra City A.C.T. 2601"},{"name":"Department of Medicine, Austin Hospital Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian FC","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Department of Immunology, John Curtin School of Medical Research, Australian National University P.O. Box 334 Canberra City A.C.T. 2601"},{"name":"Department of Medicine, Austin Hospital Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1980,10]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1980.54","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198054","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1980.54","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb198054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:05:47Z","timestamp":1695978347000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1980.54"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,10]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1980,10]]}},"alternative-id":["10.1038\/icb.1980.54"],"URL":"https:\/\/doi.org\/10.1038\/icb.1980.54","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1980,10]]}}}