{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T19:28:55Z","timestamp":1699471735790},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1980,12,1]],"date-time":"1980-12-01T00:00:00Z","timestamp":344476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1980,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>After intradermal injection of 10<jats:sup>7<\/jats:sup> promastigotes of a particular isolate of the intramacrophage protozoan parasite, <jats:italic>Leishmania tropica<\/jats:italic>, the development of disease (cutaneous lesions) is much more severe in BALB\/c than in three other mouse strains, C57BL\/6, C3H\/He and CBA\/H. Using fixed promastigotes and <jats:sup>125<\/jats:sup>I\u2010labelled protein A in a solid\u2010phase radioimmunoassay (RIA), titres of antibody were shown to increase up to about day 50 of infection. However, titres were not markedly different in BALB\/c mice compared with the other three resistant strains, although antibody levels were highest in sera from the diseased BALB\/c mice at late time points. Using isotype\u2010specific antisera in the RIA, and sera from the day 50 time point, the isotype distribution of anti\u2010promastigote antibodies was not noticeably different in sera from mice of the four genotypes with IgG<jats:sub>1<\/jats:sub> and IgG<jats:sub>2<\/jats:sub>a (IgG<jats:sub>2<\/jats:sub>b) antibodies predominating. It is concluded that differences in susceptibility to disease in this murine model of cutaneous leishmaniasis do not correlate with any decrease or increase in any particular antibody response to the promastigote.<\/jats:p>","DOI":"10.1038\/icb.1980.61","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T10:11:07Z","timestamp":1196158267000},"page":"595-601","source":"Crossref","is-referenced-by-count":18,"title":["ANTIBODIES TO <i>LEISHMANIA TROPICA<\/i> PROMASTIGOTES DURING INFECTION IN MICE OF VARIOUS GENOTYPES"],"prefix":"10.1111","volume":"58","author":[{"given":"Joseph O","family":"Olobo","sequence":"first","affiliation":[{"name":"Laboratory of Immunoparasitology, The Walter and Eliza Hall Institute of Medical Research Victoria 3050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Handma'N","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoparasitology, The Walter and Eliza Hall Institute of Medical Research Victoria 3050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan M","family":"Curtis","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoparasitology, The Walter and Eliza Hall Institute of Medical Research Victoria 3050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham F","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoparasitology, The Walter and Eliza Hall Institute of Medical Research Victoria 3050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1980,12]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1980.61","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198061","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198061.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1980.61","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb198061.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T06:53:38Z","timestamp":1695970418000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1980.61"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,12]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1980,12]]}},"alternative-id":["10.1038\/icb.1980.61"],"URL":"https:\/\/doi.org\/10.1038\/icb.1980.61","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1980,12]]}}}