{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T08:17:22Z","timestamp":1695975442037},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1981,4,1]],"date-time":"1981-04-01T00:00:00Z","timestamp":354931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1981,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In this study the effects of REN\u2010293 have been examined on the rat tail artery \u2018<jats:italic>in situ<\/jats:italic>\u2019. It was found that the drug was totally dependent on the sympathetic nerves for its vasoconstrictor action. This action was blocked by phentolamine and attenuated by pre\u2010treatment of the vessel with tyramine. When a comparative study of the vasoconstrictor effects of several sympathomimetics was performed, it was found that REN\u2010293 was more potent than tyramine and ephedrine, but less so than etilefrine. It would appear that REN\u2010293 is of interest as a pharmacological tool for examining sympathetic nerve function, but its usefulness in the therapy of orthostatic hypotension is likely to be limited, due to the very indirect nature of its sympathomimetic action.<\/jats:p>","DOI":"10.1038\/icb.1981.13","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T10:12:36Z","timestamp":1196158356000},"page":"179-182","source":"Crossref","is-referenced-by-count":0,"title":["VASCULAR RESPONSES TO REN\u2010293 (2\u2010amino\u20103[3, 5\u2010dihydroxyphenyl]\u20101\u2010propanol hydrochloride)\u2014A NEW SYMPATHOMIMETIC AGENT"],"prefix":"10.1111","volume":"59","author":[{"given":"BR","family":"Frost","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Pharmacology, University of Adelaide South Australia 5000"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DB","family":"Frewin","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Pharmacology, University of Adelaide South Australia 5000"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1981,4]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1981.13","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198113","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1981.13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb198113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T21:55:08Z","timestamp":1695938108000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1981.13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,4]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,4]]}},"alternative-id":["10.1038\/icb.1981.13"],"URL":"https:\/\/doi.org\/10.1038\/icb.1981.13","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1981,4]]}}}