{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T16:41:30Z","timestamp":1696005690560},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1982,2,1]],"date-time":"1982-02-01T00:00:00Z","timestamp":381369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1982,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>In vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> parameters of tumour resistance were examined after immunization of mice with the attenuated 11RX strain of <jats:italic>S. enteritidis.<\/jats:italic> During the bacterial carrier state produced by intraperitoneal (i.p.) or intravenous (i.v.) injection of 11RX the mice were resistant to i.p. tumour growth, could destroy i.p. injected <jats:sup>125<\/jats:sup>I\u2010 or <jats:sup>131<\/jats:sup>I\u2010labelled tumour cells <jats:italic>in vivo<\/jats:italic> and had non\u2010specifically cytotoxic peritoneal cells (PC) which could lyse <jats:sup>51<\/jats:sup>Cr\u2010labelled tumour cells <jats:italic>in vitro.<\/jats:italic> Most of the <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> cytotoxic activity could be attributed to activated macrophages (La Posta <jats:italic>et al.<\/jats:italic>, 1982). The predominantly local nature of 11RX\u2010induced anti\u2010tumour activity was indicated by the superiority of the i.p. route of infection for induction of tumour resistance and <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> cytotoxicity.<\/jats:p><jats:p>After i.v. injection of 11RX, none of the anti\u2010tumour effects outlasted the bacterial carrier state. However, after i.p. infection, a dichotomy was observed between <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> anti\u2010tumour effects. <jats:italic>In vitro<\/jats:italic> PC cytotoxicity lasted only for the length of the 11RX carrier state (approximately 30 days), whereas resistance to i.p. tumour growth lasted for 60 to 100 days and was correlated closely with cytotoxic activity measured <jats:italic>in vivo.<\/jats:italic> Possible reasons for this dichotomy are discussed.<\/jats:p>","DOI":"10.1038\/icb.1982.1","type":"journal-article","created":{"date-parts":[[2007,8,16]],"date-time":"2007-08-16T14:32:33Z","timestamp":1187274753000},"page":"1-21","source":"Crossref","is-referenced-by-count":4,"title":["<i>IN VITRO<\/i> AND <i>IN VIVO<\/i> CYTOTOXICITY INDUCED BY AN ATTENUATED <i>SALMONELLA<\/i>: RELATION TO BACTERIAL CARRIER STATE AND RESISTANCE TO TUMOUR GROWTH"],"prefix":"10.1111","volume":"60","author":[{"given":"Michael P","family":"Ashley","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, The University of Adelaide G.P.O. Box 498 Adelaide South Australia 5001"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ieva","family":"Kotlarski","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, The University of Adelaide G.P.O. Box 498 Adelaide South Australia 5001"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1982,2]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1982.1","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb19821","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb19821.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1982.1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb19821.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T23:43:54Z","timestamp":1695944634000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1982.1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982,2]]}},"alternative-id":["10.1038\/icb.1982.1"],"URL":"https:\/\/doi.org\/10.1038\/icb.1982.1","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1982,2]]}}}