{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:26:45Z","timestamp":1758817605854},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1982,4,1]],"date-time":"1982-04-01T00:00:00Z","timestamp":386467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1982,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Comparisons were drawn between the effects of <jats:italic>Nippostrongylus brasilensis<\/jats:italic> infestation upon IgE synthesis and the <jats:italic>in vivo<\/jats:italic> expression of allergic reactions to ovalbumin OV) in weanling, juvenile and adult rats. Parameters examined included total and antigen (OV)\u2010specific IgE levels in serum and the relationship between serum levels of antigen\u2010specific IgE in individual parasitized rats and the magnitude of their subsequent reaction to intravenous or intradermal antigenic challenge. On the basis of parallel trials employing non\u2010infested age\u2010mulched controls, parasitized adult and juvenile animals manifested allergic reactivity to the full potential of their individual specific antibody levels. In contrast, the magnitude of allergic reactions in parasitized weanlings was markedly depressed below that expected from their IgE antibody scores. The most notable additional feature distinguishing parasitized weanling rats from infested animals of other ages was the presence in their serum of extremely high levels of \u2018irrelevant\u2019 IgE.<\/jats:p>","DOI":"10.1038\/icb.1982.15","type":"journal-article","created":{"date-parts":[[2007,8,16]],"date-time":"2007-08-16T14:32:39Z","timestamp":1187274759000},"page":"147-157","source":"Crossref","is-referenced-by-count":8,"title":["HOST AGE DETERMINES THE EFFECTS OF HELMINTHIC PARASITE INFESTATION UPON EXPRESSION OF ALLERGIC REACTIVITY IN RATS"],"prefix":"10.1111","volume":"60","author":[{"given":"KJ","family":"Turner","sequence":"first","affiliation":[{"name":"Queensland Department of Primary Industries, Tick Fever Research Centre Wacol Queensland 4076 Australia"},{"name":"Clinical Immunology Research Unit, Princess Margaret Hospital for Children Subiaco Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EH","family":"Fisher","sequence":"additional","affiliation":[{"name":"Queensland Department of Primary Industries, Tick Fever Research Centre Wacol Queensland 4076 Australia"},{"name":"Clinical Immunology Research Unit, Princess Margaret Hospital for Children Subiaco Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PG","family":"Holt","sequence":"additional","affiliation":[{"name":"Queensland Department of Primary Industries, Tick Fever Research Centre Wacol Queensland 4076 Australia"},{"name":"Clinical Immunology Research Unit, Princess Margaret Hospital for Children Subiaco Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1982,4]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1982.15","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198215","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198215.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1982.15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb198215.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T02:29:13Z","timestamp":1696040953000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1982.15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,4]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1982,4]]}},"alternative-id":["10.1038\/icb.1982.15"],"URL":"https:\/\/doi.org\/10.1038\/icb.1982.15","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1982,4]]}}}