{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:32:16Z","timestamp":1762075936075},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1982,12,1]],"date-time":"1982-12-01T00:00:00Z","timestamp":407548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1982,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The immunological changes occurring after primary and challenge infections with <jats:italic>Strongyloides ratti<\/jats:italic> in C57B1\/6 mice are described. Serum IgM and IgG antibodies against <jats:italic>Strongyloides<\/jats:italic> antigen appeared one week after primary infection. The levels of antibody in both immunoglobulin classes increased markedly after secondary infection and persisted for at least 6 weeks. Immediate hypersensitivity (15 min footpad) reactions were transient after a primary infection, but were marked and persistent after a secondary infection. Arthus (5 h footpad) reactions were mild and very transient after a primary infection, but a persistent anamnestic response was seen after challenge infection. Cell\u2010mediated immune (24 h footpad) reactions were marked 1 week after both primary and secondary infections but were not sustained in either case. Antigen\u2010reactive cells were present in the mesenteric lymph nodes 1 week after primary infection and 1\u20134 weeks after challenge infection. No antigen\u2010reactive cells were noted in the spleen. Mesenteric lymph node (MLN) cells and spleen cells from infected or uninfected animals were stimulated with phytohaemagglutinin (PHA) or lipopolysaccharide (LPS) but did not differ significantly in their <jats:sup>3<\/jats:sup>H thymidine incorporation. A transient eosinophilia was observed after primary infection and an anamnestic response was noted after challenge infection. The possible roles of these immunological responses to worm rejection and immunopathology are considered.<\/jats:p>","DOI":"10.1038\/icb.1982.73","type":"journal-article","created":{"date-parts":[[2007,8,16]],"date-time":"2007-08-16T15:31:22Z","timestamp":1187278282000},"page":"717-729","source":"Crossref","is-referenced-by-count":11,"title":["HUMORAL AND CELL\u2010MEDIATED IMMUNE RESPONSES IN MURINE STRONGYLOIDIASIS"],"prefix":"10.1111","volume":"60","author":[{"given":"HJS","family":"Dawkins","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Western Australia Nedlands Western Australia, 6009"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SM","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Western Australia Nedlands Western Australia, 6009"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DI","family":"Grove","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Western Australia Nedlands Western Australia, 6009"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1982,12]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1982.73","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198273","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198273.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1982.73","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb198273.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T03:31:12Z","timestamp":1696044672000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1982.73"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,12]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1982,12]]}},"alternative-id":["10.1038\/icb.1982.73"],"URL":"https:\/\/doi.org\/10.1038\/icb.1982.73","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1982,12]]}}}