{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T08:23:04Z","timestamp":1758270184357},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1983,2,1]],"date-time":"1983-02-01T00:00:00Z","timestamp":412905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1983,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The effect of phomopsin, the mycotoxin of <jats:italic>Phomopsis leptostromiformis<\/jats:italic> responsible for lupinosis, was examined in pregnant rats and their embryos. A Single injection at the rate of 0\u00b7025\u20130\u00b74 mg\/kg was administered on days 6, 8, 10, 12 or 14 of pregnancy or repeated Injections at the daily rate of 0\u00b703 or 0\u00b7 09 mg\/kg were given on days 6\u00b710 or 11\u00b715. Effects on embryonic development were examined on day 20. A single dose of 0\u00b74 mg\/kg or repeated doses of 0\u00b709 mg\/kg caused heavy embryonic mortality. Repeated doses of 0\u00b703 mg\/kg over days 6\u00b710 caused a lower mortality. Foetuses that survived the higher dose rates were severely retarded in their growth and skeletal ossification was irregular. The incidence of other developmental defects was too low for phomopsin to be unequivocally implicated. The dose levels used induced lesiona of lupinosis of varying severity in the dams. Toxicity for dams and embryos was greater when the total dose was administered over 5 days than after a single injection.<\/jats:p>","DOI":"10.1038\/icb.1983.10","type":"journal-article","created":{"date-parts":[[2007,8,13]],"date-time":"2007-08-13T13:04:13Z","timestamp":1187010253000},"page":"105-115","source":"Crossref","is-referenced-by-count":5,"title":["EMBRYOTOXICITY OF PHOMOPSIN IN RATS"],"prefix":"10.1111","volume":"61","author":[{"given":"JE","family":"Peterson","sequence":"first","affiliation":[{"name":"CSIRO Division of Animal Health, Animal Health, Research Laboratory Private Bag No. 1 Parkville Victoria, 3052"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1983,2]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1983.10","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198310","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198310.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1983.10","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb198310.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T13:20:24Z","timestamp":1695993624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1983.10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,2]]}},"alternative-id":["10.1038\/icb.1983.10"],"URL":"https:\/\/doi.org\/10.1038\/icb.1983.10","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1983,2]]}}}