{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:21:41Z","timestamp":1773296501208,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1983,8,1]],"date-time":"1983-08-01T00:00:00Z","timestamp":428544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1983,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The vaccinia\u2010virus\u2010immune cytotoxic T lymphocyte (CTL) response, associated with H\u20102K<jats:sup>k<\/jats:sup> in B10, A(2R) [K<jats:sup>k<\/jats:sup>D<jats:sup>b<\/jats:sup>] mice, is much more potent than that occurring in the context of H\u20102D<jats:sup>b<\/jats:sup>. This differential reactivity is true for T\u2010cells recovered either from cerebrospinal fluid (CSF) of mice injected intra\u2010cerebrally (i.c.) with a low dose of virus or from spleen populations primed by intravenous (i.v.) inoculation of a large amount of virus. Further stimulation of CSF inflammatory cells <jats:italic>in vitro<\/jats:italic> for 7 days under limiting dilution conditions indicated that the hierarchy of cytotoxic T\u2010cell activity was a function of the relative frequencies of H\u20102K<jats:sup>k<\/jats:sup>\u2010 and H\u20102D<jats:sup>b<\/jats:sup>\u2010restricted lymphocytes. We therefore conclude that the immune response gene effect described previously for cells found in lymphoid tissue is also expressed in a virus\u2010induced inflammatory exudate in the central nervous system.<\/jats:p>","DOI":"10.1038\/icb.1983.44","type":"journal-article","created":{"date-parts":[[2007,8,13]],"date-time":"2007-08-13T13:14:17Z","timestamp":1187010857000},"page":"471-475","source":"Crossref","is-referenced-by-count":5,"title":["HIERARCHIES OF T CELL RESPONSIVENESS ARE REFLECTED IN THE DISTRIBUTION OF EFFECTOR T CELLS IN VIRAL MENINGITIS"],"prefix":"10.1111","volume":"61","author":[{"given":"PC","family":"Doherty","sequence":"first","affiliation":[{"name":"Wistar Institute of Anatomy and Biology 36th Street al Spruce Philadelphia Pa 19104 U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Korngold","sequence":"additional","affiliation":[{"name":"Wistar Institute of Anatomy and Biology 36th Street al Spruce Philadelphia Pa 19104 U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1983,8]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1983.44","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198344","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198344.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1983.44","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb198344.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:27:31Z","timestamp":1695979651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1983.44"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,8]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1983,8]]}},"alternative-id":["10.1038\/icb.1983.44"],"URL":"https:\/\/doi.org\/10.1038\/icb.1983.44","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1983,8]]}}}