{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:00:36Z","timestamp":1762297236054},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1984,10,1]],"date-time":"1984-10-01T00:00:00Z","timestamp":465436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1984,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Evidence for serological cross\u2010reactions between <jats:italic>Toxocara canis<\/jats:italic> and related nematode parasites has been sought using sera from infected mice and the immunodiagnostic excretory\/secretory (ES) antigen of <jats:italic>T. canis<\/jats:italic> larvae. Sera from mice experimentally infected with either <jats:italic>T. canis, T. cati, T. pteropodis, Toxascaris leonina or Ascaris suum<\/jats:italic> were tested for the presence of antibodies to <jats:italic>T. canis<\/jats:italic> ES antigen by solid\u2010phase radioimmunoassay (RIA) or enzyme\u2010linked immunosorbent assay (ELISA) using anti\u2010mouse IgG. <jats:italic>T. canis<\/jats:italic> ES antigen was obtained from the medium used to culture <jats:italic>T. canis<\/jats:italic> larvae, this being the same source of antigen as has been used in a highly satisfactory immunodiagnostic test for human toxocariasis (visceral larva migrans). Sera from mice infected with either <jats:italic>A. suum, T. cati<\/jats:italic> or <jats:italic>T. pieropodis<\/jats:italic> showed definite cross\u2010reactions with <jats:italic>T. canis<\/jats:italic> ES antigen in one or other of the two essays used. No reaction between anti\u2010T. <jats:italic>leonina<\/jats:italic> sera and <jats:italic>T. canis<\/jats:italic> ES antigen was demonstrated, although infection levels with this parasite were low in mice. Concerning biological activity of ES antigen, it is of some interest that mice hyperimmunised with <jats:italic>T. canis<\/jats:italic> ES antigen in adjuvant were shown to be significantly resistant to infection by <jats:italic>T. canis<\/jats:italic>.<\/jats:p>","DOI":"10.1038\/icb.1984.59","type":"journal-article","created":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T13:27:07Z","timestamp":1186666027000},"page":"619-626","source":"Crossref","is-referenced-by-count":36,"title":["ANTIBODY RESPONSES TO <i>TOXOCARA CANIS<\/i> USING SERA FROM PARASITE\u2010INFECTED MICE AND PROTECTION FROM TOXOCARIASIS BY IMMUNISATION WITH ES ANTIGENS"],"prefix":"10.1111","volume":"62","author":[{"given":"WL","family":"Nicholas","sequence":"first","affiliation":[{"name":"Queensland Institute of Medical Research, Bramston Terrace Herston Brisbane 4006 Australia"},{"name":"Immunoparasitology Unit, The Walter and Eliza Hall Institute of Medical Research Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AC","family":"Stewart","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research, Bramston Terrace Herston Brisbane 4006 Australia"},{"name":"Immunoparasitology Unit, The Walter and Eliza Hall Institute of Medical Research Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GF","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research, Bramston Terrace Herston Brisbane 4006 Australia"},{"name":"Immunoparasitology Unit, The Walter and Eliza Hall Institute of Medical Research Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1984,10]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1984.59","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198459","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198459.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1984.59","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb198459.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T04:16:14Z","timestamp":1696047374000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1984.59"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,10]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1984,10]]}},"alternative-id":["10.1038\/icb.1984.59"],"URL":"https:\/\/doi.org\/10.1038\/icb.1984.59","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1984,10]]}}}