{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:51:12Z","timestamp":1790671872335,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1985,6,1]],"date-time":"1985-06-01T00:00:00Z","timestamp":486432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1985,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Sheep experimentally depleted of copper (Cu) and infected with <jats:italic>Trichostrongylus axei<\/jats:italic> and <jats:italic>Trichostrongylus colubriformis<\/jats:italic> were studied for changes in white blood cell (WBC) populations, anti\u2010parasite antibody responses and <jats:italic>in vitro<\/jats:italic> proliferative response to phytohaemagglutinin (PHA), lipopolysaccharide (LPS) and <jats:italic>Trichostrongylus<\/jats:italic> spp. antigens. Increases in circulating total WBC, lymphocyte, monocyte and neutrophil leucocyte numbers had a bimodal distribution which was related to the different developmental stages of the nematode. Eosinophil leucocyte numbers were generally lower than those of uninfected control sheep and could be associated with parasite\u2010induced selective unresponsiveness or PHA responsive cells. The <jats:italic>in vitro<\/jats:italic> blastogenic responses of lymphocytes to PHA stimulation increased rapidly soon after infection, reaching a peak at 2 weeks, but then declined rapidly and from 5 weeks after infection responses to PHA were barely detectable. The patterns of proliferate response against LPS and <jats:italic>Trichostrongylus<\/jats:italic> spp. antigens were identical and correlated with the appearance of anti\u2010parasite antibodies in the serum. These last three responses reached their maxima 5 weeks after infection and then stabilized at a plateau around peak levels. It was concluded that, although the changes in the host immune response could not be consistently associated with interactions between Cu deficiency and infection, the results nevertheless suggest that Cu, as a micro\u2010nutrient, has a role in the mechanism of cell\u2010mediated immunity in sheep infected with <jats:italic>Trichostrongylus<\/jats:italic> spp.<\/jats:p>","DOI":"10.1038\/icb.1985.30","type":"journal-article","created":{"date-parts":[[2007,8,8]],"date-time":"2007-08-08T16:05:12Z","timestamp":1186589112000},"page":"273-281","source":"Crossref","is-referenced-by-count":9,"title":["PERIPHERAL BLOOD WHITE CELL RESPONSES DURING CONCURRENT COPPER DEFICIENCY AND GASTRO\u2010INTESTINAL NEMATODIASIS IN SHEEP"],"prefix":"10.1111","volume":"63","author":[{"given":"WK","family":"Yong","sequence":"first","affiliation":[{"name":"Department of Agriculture, Regional Veterinary Laboratory P.O. Box 406 Hamilton Victoria 3300 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LD","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Agriculture, Regional Veterinary Laboratory P.O. Box 406 Hamilton Victoria 3300 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DA","family":"Hucker","sequence":"additional","affiliation":[{"name":"Department of Agriculture, Regional Veterinary Laboratory P.O. Box 406 Hamilton Victoria 3300 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1985,6]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1985.30","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198530","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198530.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1985.30","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb198530.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T03:13:57Z","timestamp":1695957237000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1985.30"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,6]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,6]]}},"alternative-id":["10.1038\/icb.1985.30"],"URL":"https:\/\/doi.org\/10.1038\/icb.1985.30","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1985,6]]}}}