{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T14:48:51Z","timestamp":1708008531693},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1985,10,1]],"date-time":"1985-10-01T00:00:00Z","timestamp":496972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1985,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In guinea pigs deprived or ascorbic acid, the oral administration of degraded <jats:italic>E. Spinosum<\/jats:italic> carrageenan induced mild to moderate colitis, while <jats:italic>E. cottonii<\/jats:italic> consistently induced severe colitis. A variable degree of colitis was observed in scorbutic animals not receiving carrageenan. By contrast, in animals given large daily supplements of ascorbic acid, neither type of carrageenan consistently induced colitis and seven disease was rarely observed. The severe colitis induced by <jats:italic>E. cottonii<\/jats:italic> in scorbutic animals markedly affected the mid and distal colon and showed histological changes similar to human ulcerative colitis.<\/jats:p>","DOI":"10.1038\/icb.1985.58","type":"journal-article","created":{"date-parts":[[2007,8,8]],"date-time":"2007-08-08T16:07:58Z","timestamp":1186589278000},"page":"545-553","source":"Crossref","is-referenced-by-count":6,"title":["CARRAGEENAN COLITIS IN THE GUINEA PIG: PATHOLOGICAL CHANGES AND THE IMPORTANCE OF ASCORBIC ACID DEFICIENCY IN DISEASE INDUCTION"],"prefix":"10.1111","volume":"63","author":[{"given":"JM","family":"Langman","sequence":"first","affiliation":[{"name":"Institute of Medical and Veterinary Science Adelaide South Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Rowland","sequence":"additional","affiliation":[{"name":"Institute of Medical and Veterinary Science Adelaide South Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Vernon\u2010Roberts","sequence":"additional","affiliation":[{"name":"Institute of Medical and Veterinary Science Adelaide South Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1985,10]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1985.58","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198558","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198558.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1985.58","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb198558.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T20:35:41Z","timestamp":1696019741000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1985.58"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,10]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1985,10]]}},"alternative-id":["10.1038\/icb.1985.58"],"URL":"https:\/\/doi.org\/10.1038\/icb.1985.58","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1985,10]]}}}