{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:15:03Z","timestamp":1760548503886},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1986,6,1]],"date-time":"1986-06-01T00:00:00Z","timestamp":517968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1986,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>\u03b1\u2010 and \u03b2\u2010thalassaemias and other haemoglobinopathies have not so far been reported in Australian Aborigines. Using a DNA mapping technique, we tested groups of Aborigines for a deletion form of \u03b1 \u2010thalassaemia and found that there was a single \u03b1 \u2010globin gene deletion (\u2010\u03b1\/\u03b1\u03b1) in some populations. The \u03b1 \u2010globin gene deletion was detected in Aboriginal DNA samples collected from Kalumburu in the Kimberley region of Western Australia. It was found also in one sample from Mowanjum, near Derby in Western Australia, and in one from Mornington Island in the Gulf of Carpentaria. It was not observed in Aboriginal DNA samples from the central desert. Further analysis of the \u03b1 \u2010globin gene deletion revealed that it was of the 3\u00b77 kilobase (Kb) (\u2212\u03b1 <jats:sup>3\u00b77<\/jats:sup>) type. However, the \u2212\u03b1 <jats:sup>3\u00b77<\/jats:sup> deletion in the Aborigines is apparently different from that found in southern Papua New Guinea as it is linked to a different \u03b6\u2010globin gene polymorphism. The presence of this silent \u03b1 \u2010thalassaemia in several populations of Aborigines may be explained in several ways. The most likely is through contact with Macassans or other voyagers from the Indonesian and Southeast Asian areas.<\/jats:p>","DOI":"10.1038\/icb.1986.31","type":"journal-article","created":{"date-parts":[[2007,8,7]],"date-time":"2007-08-07T15:57:40Z","timestamp":1186502260000},"page":"297-306","source":"Crossref","is-referenced-by-count":8,"title":["A SINGLE \u03b1\u2010GLOBIN GENE DELETION IN AUSTRALIAN ABORIGINES"],"prefix":"10.1111","volume":"64","author":[{"given":"Pa\u2010Thal","family":"Yenchitsomanus","sequence":"first","affiliation":[{"name":"Department of Human Biology, John Curtin School of Medical Research, Australian National University Canberra A.C.T. 2601 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim M","family":"Summers","sequence":"additional","affiliation":[{"name":"Department of Human Biology, John Curtin School of Medical Research, Australian National University Canberra A.C.T. 2601 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuldeep K","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Human Biology, John Curtin School of Medical Research, Australian National University Canberra A.C.T. 2601 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip G","family":"Board","sequence":"additional","affiliation":[{"name":"Department of Human Biology, John Curtin School of Medical Research, Australian National University Canberra A.C.T. 2601 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1986,6]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1986.31","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198631","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198631.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1986.31","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb198631.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T20:08:00Z","timestamp":1695931680000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1986.31"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,6]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,6]]}},"alternative-id":["10.1038\/icb.1986.31"],"URL":"https:\/\/doi.org\/10.1038\/icb.1986.31","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1986,6]]}}}