{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:39:51Z","timestamp":1760099991587},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1986,8,1]],"date-time":"1986-08-01T00:00:00Z","timestamp":523238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aust J Exp Biol Med"],"published-print":{"date-parts":[[1986,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Five conscious rabbits each received a single injection of almitrine bismesylate via a marginal ear vein. Measurements were made of ventilation and breathing pattern using a barometric method, and blood gases, pH and lactate concentration ([Lac]) were measured from arterial blood samples throughout the hour following the injection. Almitrine caused an immediate increase in ventilation through an increase in tidal volume (V<jats:sub>T<\/jats:sub>), frequency (f) showing a small decline. After 15 min f increased to above control level and V<jats:sub>T<\/jats:sub> declined. Slower, deeper breathing was reinstated by 40 min post\u2010injection. Large changes in blood gases occurred in the first 15 min, with <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/imcb198641-math-0001.png\" xlink:title=\"urn:x-wiley:08189641:imcb198641:equation:imcb198641-math-0001\" \/> raised by 30 Torr and <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/imcb198641-math-0002.png\" xlink:title=\"urn:x-wiley:08189641:imcb198641:equation:imcb198641-math-0002\" \/> lowered by 20 Torr. These recovered to be within 10 and 7\u00b75 Torr of control at the end of 1 h. [Lac] increased steeply at first, then declined towards control levels. The acid\u2010base situation was mixed, comprising a respiratory alkalosis, resulting from CO<jats:sub>2<\/jats:sub> washout, and a metabolic acidosis from high [Lac]. These results are discussed in the context of assessing the primary and secondary effects of almitrine and recognition of the possibility that the drug may act at more than one site to alter respiration.<\/jats:p>","DOI":"10.1038\/icb.1986.41","type":"journal-article","created":{"date-parts":[[2007,8,7]],"date-time":"2007-08-07T15:59:12Z","timestamp":1186502352000},"page":"389-395","source":"Crossref","is-referenced-by-count":3,"title":["CHANGES IN VENTILATION, BREATHING PATTERN AND ACID\u2010BASE BALANCE OF CONSCIOUS RABBITS FOLLOWING INTRAVENOUS ALMITRINE"],"prefix":"10.1111","volume":"64","author":[{"given":"M","family":"Maskrey","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Tasmania G.P.O. Box Number 252C Hobart Tasmania 7001"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1986,8]]},"container-title":["Australian Journal of Experimental Biology and Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.1986.41","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198641","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/icb198641.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.1986.41","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/icb198641.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:34:43Z","timestamp":1695980083000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.1986.41"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,8]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1986,8]]}},"alternative-id":["10.1038\/icb.1986.41"],"URL":"https:\/\/doi.org\/10.1038\/icb.1986.41","archive":["Portico"],"relation":{},"ISSN":["0818-9641"],"issn-type":[{"value":"0818-9641","type":"print"}],"subject":[],"published":{"date-parts":[[1986,8]]}}}