{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T12:50:19Z","timestamp":1759063819170,"version":"3.33.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1987,6,1]],"date-time":"1987-06-01T00:00:00Z","timestamp":549504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[1987,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The immunopharmacokinetics of chloroquine were studied in<jats:italic>Plasmodium knowlesi<\/jats:italic>\u2010infected and uninfected rhesus monkeys. In control monkeys, chloroquine depressed the percentage of lymphocyte subpopulation and their proliferative response after the third dose of drug administration. The effect was maximum during day 6 to 10 after initiation of treatment. During this period the plasma level of chloroquine was high. The drug was slowly excreted and recovery in immune functions was noticed by the 20th day of treatment. On the other hand, the drug caused an irreversible effect on the proliferative response of normal lymphocytes following<jats:italic>in vitro<\/jats:italic>exposure of cells.<\/jats:p><jats:p>Interestingly, while the drug depressed the immune functions of normal animals. It reversed the immunosuppression caused by malarial parasites in infected animals. The probable mechanism of action of the drug has been discussed.<\/jats:p>","DOI":"10.1038\/icb.1987.23","type":"journal-article","created":{"date-parts":[[2007,7,20]],"date-time":"2007-07-20T08:01:57Z","timestamp":1184918517000},"page":"211-216","source":"Crossref","is-referenced-by-count":6,"title":["Effect of chloroquine on cellular immune responses of normal and<i>P. knowlesi<\/i>\u2010infected rhesus monkeys"],"prefix":"10.1111","volume":"65","author":[{"given":"RN","family":"Prasad","sequence":"first","affiliation":[{"name":"Department of Parasitology, Postgraduate Institute of Medical Education and Research Chandigarh 160012 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RC","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Postgraduate Institute of Medical Education and Research Chandigarh 160012 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NK","family":"Ganguly","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research Chandigarh 160012 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1987,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(78)90033-1"},{"key":"e_1_2_1_3_1","first-page":"229","article-title":"The tropical splenomegaly syndrome","author":"Greenwood BM","year":"1979","journal-title":"The Role of the Spleen in Immunology of Parasitic Diseases"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"937","DOI":"10.7326\/0003-4819-57-6-937","article-title":"Chloroquine in the treatment of infectious mononuclosis","volume":"57","author":"Cowley RC","year":"1962","journal-title":"Ann. 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