{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T01:59:25Z","timestamp":1744163965299},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1987,6,1]],"date-time":"1987-06-01T00:00:00Z","timestamp":549504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[1987,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Immunization of hamsters with plasma membrane (PM) antigens of virulent subline of axenic <jats:italic>Entamoeba histolytica<\/jats:italic> (NIH: 200 V) entrapped in multilamellar phosphatidyl choline liposomes conferred 100% protection to a subsequent intrahepatic amoebic challenge. In contrast, vaccination of hamsters with live amoebic trophozoites injected intradermally failed to protect any of the animals. The protected animals had significantly high levels of anti\u2010PM anti\u2010amoebic antibodies, cellular sensitization and macrophage\u2010mediated antibody\u2010dependent cytotoxicity against amoebic trophozoites. However, none of the intradermally immunized animals had anti\u2010PM anti\u2010amoebic antibodies at the time of challenge. Such animals also had significantly low macrophage\u2010mediated antibody\u2010dependent cellular cytotoxicity. The data indicate the potential prophylactic use of PM antigens against hepatic amoebic infection.<\/jats:p>","DOI":"10.1038\/icb.1987.24","type":"journal-article","created":{"date-parts":[[2007,7,20]],"date-time":"2007-07-20T08:01:57Z","timestamp":1184918517000},"page":"217-222","source":"Crossref","is-referenced-by-count":6,"title":["Elicitation of protective immunity to <i>Entamoeba histolytica<\/i> \u2014 an experimental study"],"prefix":"10.1111","volume":"65","author":[{"given":"Purnima CK","family":"Nain","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Post Graduate Institute of Medical Education and Research Chandigarh 160 012 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"VK","family":"Vinayak","sequence":"additional","affiliation":[{"name":"Division of Experimental Parasitology and Parasitic Immunology, Department of Experimental Medicine, Post Graduate Institute of Medical Education and Research Chandigarh 160 012 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1987,6]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"417","article-title":"Amoebiasis and its control","volume":"63","author":"World Health Organisation","year":"1985","journal-title":"Bull. 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