{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T21:23:05Z","timestamp":1750454585529},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1987,10,1]],"date-time":"1987-10-01T00:00:00Z","timestamp":560044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[1987,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Mice immunized with a glycolipid antigen (GL) of <jats:italic>Leishmania major<\/jats:italic> plus adjuvant are relatively resistant to subsequent infection with this protozoan parasite. The GL is affinity purified on the monoclonal antibody WIC\u201079.3 which is <jats:italic>L. major\u2010specific<\/jats:italic> and does not react with <jats:italic>L. donovani<\/jats:italic>. When another monoclonal, WIC\u2010108.3, which cross\u2010reacts with several <jats:italic>Leishmania<\/jats:italic> species, is used to affinity purify GL from <jats:italic>L. donovani<\/jats:italic>, the eluted material can partially protect genetically resistant mice against <jats:italic>L. major<\/jats:italic>. Thus, GL cross\u2010reactions may in part underlie the known protective effects of crude <jats:italic>L. donovani<\/jats:italic> antigens against <jats:italic>L. major<\/jats:italic> infection. Experiments with live parasites of the <jats:italic>L. major<\/jats:italic> isolate LRC\u2010L119, that is non\u2010pathogenic in mice, that does not survive long in macrophages <jats:italic>in vitro<\/jats:italic>, and that has not been shown to contain any WIC\u201079.3 reactive GL, indicated that this isolate wilt very effectively protect mice against subsequent infection. This raises the possibility that GL is only one of at least two different classes of vaccinating antigen capable of protectively immunizing mice in this cutaneous leishmaniasis model.<\/jats:p>","DOI":"10.1038\/icb.1987.44","type":"journal-article","created":{"date-parts":[[2007,7,20]],"date-time":"2007-07-20T08:03:50Z","timestamp":1184918630000},"page":"387-392","source":"Crossref","is-referenced-by-count":13,"title":["Heterologous protection in murine cutaneous leishmaniasis"],"prefix":"10.1111","volume":"65","author":[{"given":"GF","family":"Mitchell","sequence":"first","affiliation":[{"name":"Walter and Eliza Hall Institute of Medical Research Melbourne Victoria 3050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Handman","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Institute of Medical Research Melbourne Victoria 3050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1987,10]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"79","article-title":"Immunological regulation and control of experimental leishmaniasis","volume":"28","author":"Howard JG","year":"1986","journal-title":"Int. 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