{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:32Z","timestamp":1760188892160},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1987,2,1]],"date-time":"1987-02-01T00:00:00Z","timestamp":539136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[1987,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The presence of human papillomavirus (HPV) types 11, 16 and 18 in 77 biopsies of cervical intraepithelial neoplasia (dysplasia) and carcinoma of the uterine cervix of a sample of women from Western Australia was examined using \u201cSouthern\u201d blot hybridisation. HPV\u2010DNA was found in 17 of the 23 dysplasias and 43 of the 54 invasive carcinomas examined but not in the 5 biopsies obtained from areas assessed as normal by colposcopy and histology.<\/jats:p><jats:p>Five of 11 biopsies of mild to moderate dysplasias contained HPV type 11 (HPV\u201011), 2 HPV\u201016 and 1 HPV\u201018. Of 12 severe dysplasias\/carcinoma <jats:italic>in situ<\/jats:italic>, 2 contained HPV\u201011, 4 HPV\u201016 and 2 HPV\u201018. One biopsy contained both HPV\u201011 and HPV\u201016.<\/jats:p><jats:p>Of 45 squamous cell carcinomas examined for HPV\u2010DNA, 24 contained HPV\u201016, 5 HPV\u201011 and 1 HPV\u201018. Both HPV\u201011 and HPV\u201016 were found in 6 of the squamous cell carcinomas and 2 contained both HPV\u201016 and HPV\u201018. Of 6 adenosquamous carcinomas examined, 3 contained HPV\u2010DNA, 2 with HPV\u201016 and I with HPV\u201011. HPV types 16 or 18 were also found in 2 of 3 adenocarcinomas.<\/jats:p><jats:p>This study shows a strong association between the papillomavirus and uterine cervical cancer in a sample of women from Western Australia. HPV\u201016 was more frequently associated with severe dysplasia and cancer than with mild or moderate dysplasia supporting the view that this HPV genotype may have a greater oncogenic potential than HPV\u201011.<\/jats:p>","DOI":"10.1038\/icb.1987.9","type":"journal-article","created":{"date-parts":[[2007,7,20]],"date-time":"2007-07-20T07:57:32Z","timestamp":1184918252000},"page":"77-84","source":"Crossref","is-referenced-by-count":32,"title":["DNA sequences of human papillomavirus types 11, 16 or 18 in invasive cervical carcinoma of Western Australian women"],"prefix":"10.1111","volume":"65","author":[{"given":"JK","family":"Kulski","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Western Australia Nedlands 6009 Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan J","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Western Australia Nedlands 6009 Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EC","family":"Pixley","sequence":"additional","affiliation":[{"name":"St. Anne's Hospital, Mt Lawley 6050 Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1987,2]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"349","article-title":"Etiologic factors in cervical neoplasia","volume":"9","author":"Fenoglio CM","year":"1982","journal-title":"Seminars Oncol."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-66800-5_1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-198405000-00002"},{"key":"e_1_2_1_5_1","first-page":"161","article-title":"Papillomavirus and their association with cancer in animals and in man","volume":"3","author":"Gissmann L","year":"1984","journal-title":"Cancer Surveys"},{"key":"e_1_2_1_6_1","first-page":"379","article-title":"Condylomatous lesions of the cervix, II. 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