{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:23:15Z","timestamp":1761128595141},"reference-count":16,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[1988,10,1]],"date-time":"1988-10-01T00:00:00Z","timestamp":591667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[1988,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Active <jats:italic>Brugia pahangi<\/jats:italic> microfilariae (Mf) were injected into naive male BALB\/c mice intraperitoneally. Microfilaraemia was studied for 28 days; and Mf circulated in blood in optimum numbers from 3 to 14 days. Anti\u2010Mf respose was assessed by the rate of disappearance of Mf from blood as well as their absence from visceral organs. Sonicated antigens of Mf (MfE) and whole worm extract of adults (WWE) induced absolute protection against the establishment of Mf in mice. This potent anti\u2010Mf response elicited by sonicated antigens was intense, rapid and with stood repeated challenge infection. In comparison, immunization with <jats:italic>in vitro<\/jats:italic> excretory, secretory and metabolic antigens of Mf (MfESM) produced a partial but significant level of protection. Sera collected periodically from immunized animals showed antibody by micro\u2010ELISA compared to sham vaccinated controls. When Mf were used as targets along with the peritoneal exudate cells <jats:italic>in vitro<\/jats:italic>, sera from mice immunized with MfE and MfESM showed about four\u2010fold cellular adherence to(Mf\u2010ADCA) and 10\u2010fold killing (Mf\u2010ADCC) of Mf which was antibody\u2010dependent. Some degree of correlation was apparent when the antibody levels, Mf\u2010ADCA\/Mf\u2010ADCC activity, and Mf clearance were compared. This murine microfilaraemia model was therefore shown to be suitable for studying the host\u2010protective immune response against filarial parasites.<\/jats:p>","DOI":"10.1038\/icb.1988.43","type":"journal-article","created":{"date-parts":[[2007,7,20]],"date-time":"2007-07-20T08:05:48Z","timestamp":1184918748000},"page":"331-336","source":"Crossref","is-referenced-by-count":12,"title":["Clearance of <i>Brugia pahangi<\/i> microfilariae in immunized mice"],"prefix":"10.1111","volume":"66","author":[{"given":"GR","family":"Rajasekariah","sequence":"first","affiliation":[{"name":"The Research Centre, Pharma Division, Hindustan Ciba\u2010Geigy Ltd Goregaon Bombay 400063 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P Mukherjee","family":"Puri","sequence":"additional","affiliation":[{"name":"The Research Centre, Pharma Division, Hindustan Ciba\u2010Geigy Ltd Goregaon Bombay 400063 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Chandrashekar","sequence":"additional","affiliation":[{"name":"The Research Centre, Pharma Division, Hindustan Ciba\u2010Geigy Ltd Goregaon Bombay 400063 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Subrahmanyam","sequence":"additional","affiliation":[{"name":"The Research Centre, Pharma Division, Hindustan Ciba\u2010Geigy Ltd Goregaon Bombay 400063 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1988,10]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/3281924"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1984.tb00824.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.2307\/3280746"},{"key":"e_1_2_1_5_1","first-page":"305","article-title":"Successful development of Brugia pahangi in T\u2010cell deprived CBA mice","volume":"38","author":"Suswillo RR","year":"1981","journal-title":"Acta Trop."},{"key":"e_1_2_1_6_1","first-page":"341","article-title":"The susceptibility of BALB\/c and other inbred mouse strains to Brugia pahangi","volume":"40","author":"Howells RR","year":"1983","journal-title":"Acta Trop."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1983.tb00746.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000053713"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.4049\/jimmunol.128.4.1792","article-title":"Soluble Brugia malayi microfilarial antigens protect mice against challenge by an antibody\u2010dependent mechanism","volume":"128","author":"Kazura JW","year":"1982","journal-title":"J. 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