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Two factors have been identified: mEPF\u2010S<jats:sub>1<\/jats:sub> (Mr \u223c15 000) is major histocompatibility complex (MHC)\u2010restricted while mEPF\u2010S<jats:sub>2<\/jats:sub> (Mr \u223c55 000) is restricted to a locus (or loci) outside the MHC. In the present paper, evidence is presented which shows that EPF also induces the release of soluble mediators from human lymphocytes. With the rosette inhibition test two factors have been detected, both of similar size and genetic restriction to those described previously in the mouse. One factor, designated hEPF\u2010S<jats:sub>1<\/jats:sub> (Mr 14\u201018 000), is human lymphocyte antigen (HLA)\u2010restricted and the other, hEPF\u2010S<jats:sub>2<\/jats:sub> (Mr 50\u201060 000), appears to be restricted to a locus (or loci) outside the HLA complex.<\/jats:p>","DOI":"10.1038\/icb.1989.31","type":"journal-article","created":{"date-parts":[[2007,7,20]],"date-time":"2007-07-20T07:40:56Z","timestamp":1184917256000},"page":"205-208","source":"Crossref","is-referenced-by-count":16,"title":["Genetically\u2010restricted effector molecules released by human lymphocytes in response to early pregnancy factor"],"prefix":"10.1111","volume":"67","author":[{"given":"Barbara","family":"Rolfe","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Queensland Herston Brisbane Qld 4029 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Quinn","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Queensland Herston Brisbane Qld 4029 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stavrosia","family":"Athanasas","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Queensland Herston Brisbane Qld 4029 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Cavanagh","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Queensland Herston Brisbane Qld 4029 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halle","family":"Morton","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Queensland Herston Brisbane Qld 4029 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/249459a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1976.0054"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/278649a0"},{"key":"e_1_2_1_5_1","first-page":"45","volume":"51","author":"Rolfe BE","year":"1983","journal-title":"Clin. 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