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Patient\/control comparison showed that Gm homozygosity was increased in the CREST\/PSS group (<jats:italic>P<\/jats:italic>&lt;0\u00b705) but not in the SLE group. HLA\u2010DR5 is significantly increased in frequency in this series of CREST\/PSS patients compared to controls (<jats:italic>P<\/jats:italic>&lt;0\u00b7001), and log linear regression analysis showed that although both DR5 and Gm homozygosity were significant factors determining disease susceptibility, there was no evidence of an interactive effect between these two groups of genes increasing the predisposition to CREST\/PSS.<\/jats:p>","DOI":"10.1038\/icb.1989.39","type":"journal-article","created":{"date-parts":[[2007,7,20]],"date-time":"2007-07-20T07:41:37Z","timestamp":1184917297000},"page":"261-265","source":"Crossref","is-referenced-by-count":3,"title":["Gm allogenotype distribution and lack of HLA\u2010DR, Gm interaction in SLE and CREST\/PSS"],"prefix":"10.1111","volume":"67","author":[{"given":"Elizabeth C","family":"Jazwinska","sequence":"first","affiliation":[{"name":"Human Genetics Group, John Curtin School of Medical Research, Australian National University Canberra ACT 2601 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Dunckley","sequence":"additional","affiliation":[{"name":"Human Genetics Group, John Curtin School of Medical Research, Australian National University Canberra ACT 2601 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A","family":"Gatenby","sequence":"additional","affiliation":[{"name":"Royal Prince Alfred Hospital Camperdown NSW 2050 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan W","family":"Serjeantson","sequence":"additional","affiliation":[{"name":"Human Genetics Group, John Curtin School of Medical Research, Australian National University Canberra ACT 2601 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(84)90006-4"},{"key":"e_1_2_1_3_1","first-page":"52","article-title":"Gm and Km allotypes, immune response and disease susceptibility","volume":"19","author":"Whittingham S","year":"1986","journal-title":"Monogr. 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