{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:17:52Z","timestamp":1767626272945},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:00:00Z","timestamp":1513900800000},"content-version":"vor","delay-in-days":10005,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunology &amp; Cell Biology"],"published-print":{"date-parts":[[1990,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The effects of Piroxicam on the production and activity of lymphoproliferative cytokines (LC) produced by mononuclear phagocytes (MNP) were examined. <jats:italic>In vitro<\/jats:italic>, Piroxicam did not affect IL\u20101 induced thymocyte proliferation (LAF assay). However, the LAF activity from lipopolysaccharide (LPS)\u2010treated MNP cultures was increased after Piroxicam (0\u00b71\u201320 \u03bcol\/L) treatment. The increase in apparent LC activity was largely due to suppression of prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>) production. Peripheral blood, spleen and thymus lymphocytes from animals predosed with Piroxicam (5 mg\/kg per day for 3 days) synthesized more DNA than untreated mice (as measured by [<jats:sup>3<\/jats:sup>H]\u2010thymidine uptake <jats:italic>ex vivo<\/jats:italic>). MNP from Piroxicam\u2010treated animals produced significantly more LC. Piroxicam had similar effects in both inflamed and non\u2010inflamed mice. Piroxicam and other non\u2010steroidal anti\u2010inflammatory drugs (NSAID) may therefore stimulate or modulate the immune functions requiring lymphoproliferation by suppressing the formation of PGE<jats:sub>2<\/jats:sub>, a natural inhibitor of both LC production and LC\u2010induced lymphoproliferation.<\/jats:p>","DOI":"10.1038\/icb.1990.31","type":"journal-article","created":{"date-parts":[[2007,7,6]],"date-time":"2007-07-06T11:17:09Z","timestamp":1183720629000},"page":"225-230","source":"Crossref","is-referenced-by-count":20,"title":["The cyclo\u2010oxygenase inhibitor, Piroxicam, enhances cytokine\u2010induced lymphocyte proliferation <i>in vitro<\/i> and <i>in vivo<\/i>"],"prefix":"10.1111","volume":"68","author":[{"given":"D. R.","family":"Haynes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. F.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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