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Two groups were identified based on incidence of acute bronchitis \u2014 subjects who were \u2018infection\u2010prone\u2019 (2\u20135 infections per year) and those who were \u2018non\u2010infection\u2010 prone\u2019 (0\u20131 infections per year). Minor differences in clinical parameters existed, except for smoking experience. The non\u2010infection\u2010prone group included more current smokers, and the total smoking experience (in \u2018pack years\u2019) was significantly greater in this group. Between\u2010year analysis demonstrated a stability of classification, established after a minimum of two years\u2019 prospective observation. Parameters of the host\u2010parasite relationship were assessed in both groups. A significantly greater polybacterial colonization of the oropharynx was observed for chronic bronchitics, both infection\u2010prone (<jats:italic>P<\/jats:italic> &lt; 0.0001) and non\u2010infection\u2010prone (<jats:italic>P<\/jats:italic> &lt; 0.001), compared with control subjects. Infection\u2010prone chronic bronchitics had significantly greater total bacteria cultured from the oropharynx compared to the non\u2010in feet ion\u2010prone group (<jats:italic>P<\/jats:italic> &lt; 0.05); adherence of indigenous microflora to buccal epithelial cells, in particular Gram\u2010positive cocci (<jats:italic>P<\/jats:italic> &lt; 0.01) and <jats:italic>in vitro<\/jats:italic> adherence of non\u2010serotypable <jats:italic>Haemophilus influenzae<\/jats:italic> to buccal cells (<jats:italic>P<\/jats:italic> &lt; 0.05) compared with the control and non\u2010infection\u2010prone groups. These studies suggest that an important variation in subjects with chronic bronchitis is the binding capacity of epithelial cells for bacteria, which when increased enhances susceptibility to colonization and clinical infection.<\/jats:p>","DOI":"10.1038\/icb.1994.22","type":"journal-article","created":{"date-parts":[[2007,7,3]],"date-time":"2007-07-03T09:15:03Z","timestamp":1183454103000},"page":"143-151","source":"Crossref","is-referenced-by-count":20,"title":["An alteration in the host\u2010parasite relationship in subjects with chronic bronchitis prone to recurrent episodes of acute bronchitis"],"prefix":"10.1111","volume":"72","author":[{"given":"DIANA C.","family":"TAYLOR","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROBERT L.","family":"CLANCY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALLAN W.","family":"CRIPPS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HENRY","family":"BUTT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LAWRENCE","family":"BARTLETT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KEITH","family":"MURREE\u2010ALLEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1990.tb00367.x"},{"key":"e_1_2_1_3_2","first-page":"534","article-title":"The bacteriology of chronic bronchitis","volume":"2","author":"May J. 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