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Intraperitoneal injection of MDF in mice resulted in a rapid increase in capillary permeability in a dose\u2010dependent manner as assessed by leakage of intravenously injected radiolabelled albumin ([<jats:sup>125<\/jats:sup>I]\u2010albumin) or Evans blue dye. Intradermal inoculation of MDF in rabbits caused [<jats:sup>51<\/jats:sup>Cr]\u2010labelled neutrophil emigration and accumulation into injected sites. Peak plasma leakage and neutrophil infiltration were observed at 1 h following MDF inoculation, and plasma leakage was restored by 2.5 h. The increase in capillary permeability was sensitive to pretreatment of mice with avil and ranitidine (H1 and H2 histamine receptor blockers, respectively), resulting in abrogation of the response; indomethacin, a prostaglandin synthetase inhibitor, did not have any effect.<\/jats:p>","DOI":"10.1038\/icb.1994.30","type":"journal-article","created":{"date-parts":[[2007,7,3]],"date-time":"2007-07-03T09:17:11Z","timestamp":1183454231000},"page":"200-204","source":"Crossref","is-referenced-by-count":8,"title":["Regulation of vascular permeability by macrophage\u2010derived chemotactic factor produced in Japanese encephalitis"],"prefix":"10.1111","volume":"72","author":[{"given":"NIVEDITA","family":"KHANNA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ASHA","family":"MATHUR","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U. 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