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This report demonstrates that the \u2018sunburn\u2019 response, both <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>, is accompanied by rapid degranulation of cutaneous mast cells, with consequential release of intracellular stores of TNF. Epidermal keratinocytes were only minor contributors to local TNF production. Expression of the TNF\u2010inducible CD62E (E\u2010selectin\/ELAM\u20101) and CD54 adhesion molecules on cutaneous endothelium occurred 2 h following mast cell degranulation, and this event was sensitive to blockade of mast cells with disodium cromoglycate. These results indicate that TNF release in skin in the acute sunburn response can largely be attributed to mast cells.<\/jats:p>","DOI":"10.1038\/icb.1995.37","type":"journal-article","created":{"date-parts":[[2007,7,3]],"date-time":"2007-07-03T09:06:00Z","timestamp":1183453560000},"page":"226-233","source":"Crossref","is-referenced-by-count":77,"title":["Ultraviolet B irradiation of skin induces mast cell degranulation and release of tumour necrosis factor\u2010\u03b1"],"prefix":"10.1111","volume":"73","author":[{"given":"LAURENCE J","family":"WALSH","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0190-9622(81)70103-8","article-title":"The human sunburn reaction: histologic and biochemical studies","volume":"5","author":"Gilchrest BA","year":"1991","journal-title":"J. Am. Acad. 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