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The effects of diffuse (DL) and linearly polarized (LPL) light were compared on models <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo.<\/jats:italic><\/jats:p><jats:p>Experiments <jats:italic>in vitro<\/jats:italic> were performed on human lymphocytes to study their blast\u2010transformation and rosette\u2010formation abilities. Both DL and LPL increased the number of blast\u2010transformed cells even in a lymphocyte culture without PHA, and reduced rosette\u2010formation of T lymphocytes. LPL had a more pronounced effect.<\/jats:p><jats:p> <jats:italic>In vivo<\/jats:italic> exposure to DL and LPL of the spleens of tumour\u2010bearing mice caused the appearance of factor(s) in their serum, inhibiting the incorporation <jats:italic>in vitro<\/jats:italic> of [<jats:sup>3<\/jats:sup>H]\u2010thymidine into the tumour cells obtained from non\u2010exposed animals. In the other series of experiments serum samples were taken from tumorous animals after the exposure of their spleens to LPL. Following the daily administration of these sera to another group of non\u2010exposed tumorous mice a decreasing tendency of the mitotic kinetics of ascites tumour was observed.<\/jats:p><jats:p>The application of visible (preferably linearly polarized) light for the stimulation of human immune competent cells, and clinical trials with extracorporeal irradiation of blood for the promotion of natural defences of an immune\u2010repressed organism are suggested.<\/jats:p>","DOI":"10.1038\/icb.1995.39","type":"journal-article","created":{"date-parts":[[2007,7,3]],"date-time":"2007-07-03T09:06:00Z","timestamp":1183453560000},"page":"239-244","source":"Crossref","is-referenced-by-count":26,"title":["Effect of visible light on some cellular and immune parameters"],"prefix":"10.1111","volume":"73","author":[{"given":"TAMARA","family":"KUBASOVA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAGDOLNA","family":"HORV\u00c1TH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KATALIN","family":"KOCSIS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00c1RTA","family":"FENY\u00d6","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-3992(82)90064-0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-3992(84)90029-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900010308"},{"key":"e_1_2_1_5_2","first-page":"87","article-title":"Trigger mechanisms of therapeutic action of autologous blood photomodified by visible light (laser and daylight) in surgical patients","volume":"146","author":"Samoilova KA","year":"1991","journal-title":"Vestn. 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