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It is proposed that antigens presented by epithelial cells to intrinsic T cell populations in the mucosa induce anti\u2010inflammatory immune responses, while antigens presented to conventional T cells by lamina propria APC predisposes to inflammation. The pathogenesis of coeliac disease is attributed to three factors: a defect in antigen processing by epithelial cells; the intrinsic properties of the gliadins; and the HLA\u2010D haplotype of the individual. It is suggested that MHC class II molecules play a role in antigen uptake by enterocytes, in addition to their function in antigen presentation to T cells.<\/jats:p>","DOI":"10.1038\/icb.1995.67","type":"journal-article","created":{"date-parts":[[2007,7,3]],"date-time":"2007-07-03T09:09:07Z","timestamp":1183453747000},"page":"433-439","source":"Crossref","is-referenced-by-count":13,"title":["Absorption and presentation of antigens by epithelial cells of the small intestine: Hypotheses and predictions relating to the pathogenesis of coeliac disease"],"prefix":"10.1111","volume":"73","author":[{"given":"GRAHAM","family":"MAYRHOFER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8924(92)90099-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(91)90133-E"},{"key":"e_1_2_1_4_2","first-page":"19","volume-title":"Immunopharmacology of Epithelial Barriers","author":"Mayrhofer G.","year":"1994"},{"key":"e_1_2_1_5_2","first-page":"631","article-title":"The induction of tolerance to a soluble protein antigen by oral administration","volume":"27","author":"Thomas HC","year":"1974","journal-title":"Immunology"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.152.6.1459"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.2.440"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/296651a0"},{"key":"e_1_2_1_9_2","first-page":"15","article-title":"Intemalization in vivo of cholera toxin in the small intestinal epithelium of the rat","volume":"92","author":"Hansson H\u2010A","year":"1984","journal-title":"Acta Pathol Microbiol Scand"},{"key":"e_1_2_1_10_2","first-page":"168","volume-title":"Mucosal Immunology","author":"Linder J","year":"1990"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1469-185X.1984.tb00708.x","article-title":"Intestinal assimilation of intact peptides and proteins from the diet \u2010a neglected field","volume":"59","author":"Gardener MLG.","year":"1984","journal-title":"Biol Rev."},{"key":"e_1_2_1_12_2","first-page":"1","volume-title":"Local Immune Responses of the Gut","author":"Mayrhofer G.","year":"1984"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(77)80254-0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529309096073"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90003-9"},{"key":"e_1_2_1_16_2","first-page":"379","article-title":"Functional characteristics of the veiled cells in afferent lymph from the rat intestine","volume":"58","author":"Mayrhofer G","year":"1986","journal-title":"Immunology"},{"key":"e_1_2_1_17_2","first-page":"281","article-title":"Lymph\u2010borne (veiled) dendritic cells can acquire and present intestinally administered antigens","volume":"73","author":"Liu LM","year":"1991","journal-title":"Immunology"},{"key":"e_1_2_1_18_2","first-page":"A1030","article-title":"The response of intestinal T cells to oral antigen","volume":"106","author":"Hurst SD","year":"1994","journal-title":"Gastroenterology"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.5.1146"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-7915(93)90012-H"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830200734"},{"key":"e_1_2_1_22_2","first-page":"253","article-title":"The role of antigen recognition and suppressor cells in mice with oral tolerance to ovalbumen","volume":"56","author":"Mowat AMcI.","year":"1985","journal-title":"Immunology"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.5.1471"},{"key":"e_1_2_1_24_2","first-page":"1","article-title":"Antigen presentation by epithelial cells of the rat small intestine. 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